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| 1 | Gastric cancer with peritoneal metastases: Efficiency of standard treatment methods显示文摘BACKGROUND Peritoneal metastasis(PM),arising from gastric cancer(GC),is the most common pattern of synchronous and metachronous dissemination and is generally associated with poor prognosis.New therapeutic modalities are being increasingly employed for such patients.AIM To develop more advanced methods,it becomes necessary to study the results of existing standard treatment methods in patients with PM in order to perform a comparative analysis of the strategies.METHODS A retrospective analysis of the efficiency of standard treatment methods(i.e.,palliative chemotherapy,palliative gastrectomy,and the best supportive care)was performed on 200 GC patients with synchronous PM.RESULTS The overall survival(OS)rate in 200 GC patients with PM under standard treatment was 5.4 mo.One-year survival occurred in 18.4%of patients.In multivariate analysis,the survival rate was significantly influenced by the following factors:Presence of extraperitoneal metastases,and stage of PM according to both the Japanese Gastric Cancer Association(JGCA)and the peritoneal cancer index(PCI).The median OS and 1-year survival of patients withР1,P2,and P3(JGCA)carcinomatosis were 9.8 mo,6.7 mo,and 4.0 mo,and 47.2%,18.8%,and 5.1%,respectively.The application of the palliative gastrectomy resulted in an increase in the median OS by up to 17 mo compared to the conservative approach where the value was 8.5 mo(P=0.05)in patients withР1РМ.In patients withР3,palliative chemotherapy increased the OS by up to 5.6 mo compared to the OS of 3.2 mo(P=0.0006)for best supportive care.The median OS and 1-year survival of patients withРCI of 1-6,7-12 and 13+points were 8.5 mo,4.2 mo,and 4.1 mo,and 39.8%,6.7%,and 5.5%,respectively.Palliative gastrectomy increased the median OS to 12.6 mo compared to conservative approach of 8.0 mo(P=0.03)in patients withРCI of 1-6 points.In patients withРCI 13+points,only palliative chemotherapy increased the OS to 6.0 mo compared to the OS of 3.4 mo for best supportive care(P=0.0008).CONCLUSION GC patients with PM are characterized by extremely poor prognoses.Long-term survivors were found in the group with PCI of 1-6 points,and there was no survival difference in groups with PCI 7-12 vs PCI 13+points.Palliative gastrectomy could prove effective in treating patients with early stage PM.The three standard treatment methods are equally effective for moderate stages of PM.In cases with advanced peritoneal carcinomatosis,a significant increase in prognosis was registered only after treatment with palliative chemotherapy. | Roman Yarema МyronОhorchak Petro Hyrya Yuriy Kovalchuk Victor Safiyan Ivan Karelin Severyn Ferneza Markiyan Fetsych Myron Matusyak Yuriy Oliynyk Тaras Fetsych | 2020 | World Journal of Gastrointestinal Oncology2020，12，5： | 3 |
| 2 | Non-invasive assessment of myocardial recovery on chronic left ventricular assist device:results associated with successful device removal 显示文摘 | Gorcsan J 3rd Severyn D Murali S | 2003 | J Heart Lung Transplant2003，22，12： | 1 |
| 3 | Surgical emergencies in the intravenous drug user显示文摘 | Calder KK Severyn FA | 2003 | Emerg Med Clin North Am2003，21，4： | 1 |
| 4 | Advances of a spatial sine testing system显示文摘 | Severyn A J Barney P S Rost W Brown D L | 1989 | International Modal Analysis Conference Las Vegas Nevada1989，，： | 1 |
| 5 | Cross-comparison of car- diac output trending accuracy of LiDCO, PiCCO, FloTrac and pul- monary artery catheters显示文摘 | HADIAN M KIN H SEVERYN D | 2010 | Critical Care2010，14，11： | 1 |
| 6 | Quantification of radial mechanical dyssynchrony in patients with left bundle branch block and idiopathic dilated cardiomyopathy without conduction delay by tissue displacement imaging显示文摘 | Sade LE Kanzaki H Severyn D | 2004 | Am J Cardiol2004，94，4： | 1 |
| 7 | Quantification of radial mechanical dyssynchrony in patients with left bundle branch block and idiopathic dilated cardiomyopathy without conduction delay by tissue displacement imaging 显示文摘 | SADE L E KANZAKI H SEVERYN D | 2004 | Am J Cardiol2004，94，4： | 1 |
| 8 | Cross-comparison of cardiac output trending accuracy of LiDCO, PiCCO, FloTrac and pulmonary artery catheters显示文摘 | Hadian M Kim HK Severyn DA | 2010 | Crit Care2010，14，6： | 1 |
| 9 | Quantification of radialmechanical dyssynchrony in patients with left bundie branch block and idiopathic dilated cardiomyopathy without conduction delay by tissue displacement imaging显示文摘 | SADE LE KANZAKI H SEVERYN D | 2004 | Am J Cardiol2004，94，4： | 1 |
| 10 | Influence of alterations in loading on mitral annular velocity by tissue Doppler echocardiography and its associated ability to predict filling pressures显示文摘 | Jacques DC Pinsky MR Severyn D | 2004 | Chest2004，126，6： | 1 |
| 11 | The effects of vaso- active drugs on pulse pressure and stroke volume varia- tion in postoperative ventilated patients 显示文摘 | Hadian M Severyn DA Pinsky MR | 2011 | J Crit Care2011，26，3： | 1 |
| 12 | Cross-comparison of cardiac output trending accuracy of LiDCO, PiCCO, FioTrac and pulmonary artery catheters 显示文摘 | Hadian M Kim HK Severyn DA | 2010 | Crit Care2010，14，6： | 1 |
| 13 | Molecular biology,genetics and biochemistry of the repulsive guidance molecule family显示文摘 | Severyn C J Shinde U Rotwein P | 2009 | Biochem J2009，422，3： | 1 |
| 14 | Second-generation tissue Doppler with angle-corrected color-coded wall displacem ent for quantitative assessment of regional left ventricular function显示文摘 | Sade LE Severyn DA Kanzaki H | 2003 | Am J Cardiol2003，92，5： | 1 |
| 15 | Quantification of radial mechanical dyssynchrony in patients with left bundle branch block and idiopathic dilated cardiomyopathy without conduction delay by tissue displacement imaging显示文摘 | Sade LE Kanzaki H Severyn D | 2004 | Am J Cardiol2004，94，： | 1 |
| 16 | Quantification of radial me- chanical dyssynchrony in patients with left bundle branch block and idiopathic dilated cardiomyopathy without condunc- tion delay by tissue displacement imaging显示文摘 | Sada LE Kanzaki H Severyn D | 2004 | Am J' Cardiol2004，94，： | 1 |
| 17 | Molecular biology, genetics and biochemistry of the repulsive guidance molecule family 显示文摘 | Severyn C J Shinde U Rotwein P | 2009 | Bio- chem J2009，422，3： | 1 |
| 18 | Influence of alterations in loading on mitral annular velocity by tissue Doppler echocardiography and its associated ability to predict filling pressures显示文摘 | Jacques DC Pinsky MR Severyn D Gorcsan J | 2004 | Chest2004，126，： | 1 |
| 19 | The effects of vasoactive drugs on pulse pressure and stroke volume variation in postoperative ventilated patients显示文摘 | Hadian M Severyn DA Pinsky MR | 2011 | J Crit Care2011，26，3： | 1 |
| 20 | Quantification of radial mechanical dyssynchrony in patients with left bundle branch block and idiopathic dilated cardiomyopathy without conduction delay by tissue displacement imaging显示文摘 | Sade LE Kanzaki H Severyn D | 2004 | Am J Cardiol2004，94，4： | 1 |
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