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| 1 | 三网融合下充电服务网规划与运营探讨显示文摘电动汽车由于其节能减排的特点而呈现快速发展趋势。作为电动汽车的重要支撑,充电服务网的规划布局与运营模式决定了电动汽车的发展前景。首先,基于充电服务网基本元素及发展形态的研究,总结了多因素影响下的电动汽车集群规模推演与充电负荷预测方法。其次,进行充电服务网与配电网、交通网的耦合关系分析,建立三网融合下的综合评价指标体系,评估三网匹配程度。对充电基础设施规划方法的发展进行了系统阐述,提出了三网协同规划研究方法。分析了充电服务网价格机制及运营策略,提出了多重因素影响的充电服务费制定策略。最后,概述了在泛在电力物联背景下充电服务网的新型业务形态。 | 刘俊勇 向月 姚昊天 唐铄雅 Shafqat Jawad | 2019 | 电力系统保护与控制2019，47，12： | 12 |
| 2 | Stability analysis of different cotton genotypes under normal and water-deficit conditions显示文摘Cotton plant observes significant reduction in seed cotton yield when subjected to water stress.To find out genotypes having better drought tolerance,seven genotypes of Gossypium hirsutum L.were tested under two moisture levels,i.e.,normal and water deficit stress conditions at five locations of Punjab,Pakistan(Faisalabad,Sahiwal,Vehari,Rahim Yar Khan,and Bahawalpur)in 2013 and 2014.Genotype×environment interaction(GEI)was studied using the genotype main effects and genotype by environment interaction(GGE)biplot and additive main effect and multiplicative interaction analysis.The genotypes G3(7001/11)and G6(FH-942)were stable under normal condition,while under drought condition,the stable genotype was G5(FH-326)when analysed using additive main effects and multiplicative interaction(AMMI)biplot scheme.While GGE biplot analysis on the basis of best performance revealed that under normal condition the genotypes,G1(L-13/10)and G2(FH-2056/10),carrying the common position in biplot.Whereas,under water deficit stress condition,G5 was the best adaptive genotype at all five locations.In the same way,ranking of genotypes showed that the G5 was the ideal genotype under both conditions.So,it is concluded that the genotype G5(FH-326)was found best for water deficit stress condition and can be cultivated under water scarce areas of Punjab. | Muhammad Riaz Jehanzeb Farooq Saghir Ahmed Muhammad Amin Waqas Shafqat Chattha Maria Ayoub Riaz Ahmed Kainth | 2019 | Journal of Integrative Agriculture2019，18，6： | 5 |
| 3 | Numerical simulation of multi-phase combustion flow in solid rocket motors with metalized propellant显示文摘Multi-phase flowfield simulation has been performed on solid rocket motor and effect of multi-phases on the performance prediction of the solid rocket motor(SRM) is investigation.During the combustion of aluminized propellant,the aluminum particles in the propellant melt and formliquid aluminum at the burning propellant surface.So the flow within the rocket motor is multi phase or two phase because it contains droplets and smoke particles of Al2O3.Flowsi mulations have been performed on a large scale motor,to observe the effect of the flowfield onthe chamber and nozzle as well.Uniform particles diameters and Rosin-Rammler diameter distribution method that is based on the assumption that an exponential relationship exists betweenthe droplet diameter,dand mass fraction of droplets with diameter greater thandhave been used for the si mulation of different distribution of Al2O3 droplets present in SRM.Particles sizes in the range of 1-100μm are used,as being the most common droplets.In this approachthe complete range of particle sizes is dividedinto a set of discrete size ranges,eachto be defined by single streamthat is part of the group.Roe scheme-flux differencing splitting based on approxi mate Riemann problem has been used to si mulate the effects of the multi-phase flowfeild.This is second order upwind scheme in which flux differencing splitting method is employed.To cater for the turbulence effect,Spalart-All maras model has been used.The results obtained show the great sensitivity of this diameters distribution and particles concentrations to the SRMflowdynamics,primarily at the motor chamber and nozzle exit.The results are shown with various sizes of the particles concentrations and geometrical configurations including models for SRM and nozzle.The analysis also provides effect of multi-phase on performance prediction of solid rocket motor. | SHAFQAT Wahab | 2009 | 航空动力学报2009，24，7： | 4 |
| 4 | Global histone post-translational modifications and cancer:Biomarkers for diagnosis,prognosis and treatment?显示文摘Global alterations in epigenetic landscape are now recognized as a hallmark of cancer. Epigenetic mechanismssuch as DNA methylation,histone modifications,nucleosome positioning and non-coding RNAs are proven to have strong association with cancer. In particular,covalent post-translational modifications of histone proteins are known to play an important role in chromatin remodeling and thereby in regulation of gene expression. Further,histone modifications have also been associated with different aspects of carcinogenesis and have been studied for their role in the better management of cancer patients. In this review,we will explore and discuss how histone modifications are involved in cancer diagnosis,prognosis and treatment. | Shafqat Ali Khan Divya Reddy Sanjay Gupta | 2015 | World Journal of Biological Chemistry2015，6，4： | 4 |
| 5 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 6 | 单壁碳和多壁碳纳米管内多孔纤毛脉动诱导流体流动的熵分析(英文)显示文摘对均匀磁场和多孔介质作用下水平纤毛管内黏性纳米流体流动的热力学进行分析。另外,对存在内部热源和热辐射的情况也进行了能量分析。加入碳纳米管(CNTs)增强了基流水的热导率。通过公式转换得到一组非线性耦合偏微分方程。通过相似变量的转换,将控制微分系统转化为一个常微分系统。计算了温度、动量和压力梯度分布的封闭形式的精确解。本研究主要研究了碳纳米管的导电性,讨论了不同流线的模式。热力学分析表明,电流系统的熵随着Brinkmann 数、磁性参数、纳米粒子浓度参数和Darcy 数的增大而增大。 | Muhammad N ABRAR Muhammad SAGHEER Shafqat HUSSIAN | 2019 | Journal of Central South University2019，26，8： | 3 |
| 7 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 8 | Cloning and expression of a novel Na+-dependent neutral amino acid transporterally related to mammalian Na/glutamate cotransporters显示文摘 | Shafqat S Tamarappoo B K Kilberg M S | 1993 | Biol Chem1993，268，15： | 1 |
| 9 | Hep27,a member of the short-chain dehydrogenase/reductase family,is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue显示文摘 | Shafqat N Shafqat J Eissner G | 2006 | Cell Mol Life Sci2006，63，10： | 1 |
| 10 | Stroke-associated pneumonia:microbiological data and outcome显示文摘 | Hassan A Khealani BA Shafqat S | 2006 | Singapore Med J2006，47，3： | 1 |
| 11 | Stroke-associated pneumonia:microbiological data and outcome显示文摘 | Hassan A Khealani BA Shafqat S | 2006 | Singapore Med J2006，47，3： | 1 |
| 12 | Stroke-associated pneumonia: microbiological date and outcome 显示文摘 | Hassan A Khealani BA Shafqat S | 2006 | Singapore Medical Journal2006，47，3： | 1 |
| 13 | Tightrope fixation of ankle synd- esmosis injuries: Clinical outcome, complications and techni-que modification显示文摘 | Naqvi GA Shafqat A Awan N | 2012 | Injury2012，43，6： | 1 |
| 14 | Stroke- associated pneumonia: microbiological data and outcome显示文摘 | HASSAN A KHEALANI B A SHAFQAT S | 2006 | Singapore Med J2006，47，： | 1 |
| 15 | Stroke-associated pneumonia: microbiological data and outcome显示文摘 | Hassan A Khealani BA Shafqat S | 2006 | Singapore Med J2006，47，3： | 1 |
| 16 | Functional recovery after rehabilitation for cerebellar stroke显示文摘 | Kelly PJ Stein J Shafqat S | 2001 | Stroke2001，32，： | 1 |
| 17 | Empirical mode decomposition (EMD) analysis of HRV date froMocally anesthetized patients 显示文摘 | Shafqat K Pal SK Kumari S | 2009 | Conf Proc IEEE Eng MOd Biol Soc2009，2009，： | 1 |
| 18 | Functional recovery following rehabilitation after hemorrhagic and ischemic stroke显示文摘 | Kelly PJ Furie KL Shafqat S | 2003 | Arch Phys Med Rehabil2003，84，： | 1 |
| 19 | Holter monitoring in the diagnosis of stroke mechanism 显示文摘 | Shafqat S Kelly PJ Furie KL | 2004 | Intern Med2004，34，6： | 1 |
| 20 | Molecular effects of proinsulin C-peptide显示文摘 | Johansson J Ekberg K Shafqat J | 2002 | Bioehem and Biophys Res Commun2002，295，9： | 1 |
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