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| 1 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 2 | Statistical issues and approaches in endophenotype research显示文摘The endophenotype concept was initially proposed to enhance the power of genetic studies of complex disorders. It is closely related to the genetic component in a liability-threshold model; a perfect endophenotype should have a correlation of 1 with the genetic component of the liability to disease. In reality, a putative endophenotype is unlikely to be a perfect representation of the genetic component of disease liability. The magnitude of the correlation between a putative endophenotype and the genetic component of disease liability can be estimated by fitting multivariate genetic models to twin data. A number of statistical methods have been developed for incorporating endophenotypes in genetic linkage and association analyses with the aim of improving statistical power. The most recent of such methods can handle multiple endophenotypes simultaneously for the greatest increase in power. In addition to increasing statistical power, endophenotype research plays an important role in helping to understand the mechanisms which connect the associated genetic variants with disease occurrence. Novel statistical approaches may be required for the analysis of the complex relationships between endophenotypes at different levels and how they converge to cause the occurrence of disease. | SHAM Pak Chung CHERNY Stacey S HALL Mei-Hua | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 3 | Accumulation of heavy metals in two crop seeds due to soil contamination as determined by neutron activation analysis techniques显示文摘AcumulationofheavymetalsintwocropsedsduetosoilcontaminationasdeterminedbyneutronactivationanalysistechniquesM.F.AbdelSabourS... | M.F.Abdel Sabour Soil and Water Department, Nuclear Research Center, Cairo, Egypt A.S.Abdel Haleem Hot Lab’s Center, Atomic Energy Authority, Cairo, Egypt A.Sroor, N.Abdel Baset Nuclear Physics Lab, Girls Faculty, Ain Shams University, Egypt R.A.Zaghloul Mubarak City for Scientific Research and Technology, Egypt | 1998 | Journal of Environmental Sciences1998，10，2： | 2 |
| 4 | Clinicopathologic significance of plasma matrix Metalloproteinase-2 and -9 levels in patients with undifferentiated nasopharyngeal carcinoma显示文摘 | WONG T S KWONG D L SHAM J S | 2004 | Eur J Surg Oncol2004，30，5： | 1 |
| 5 | Prokineticin-1 (Prok-1) works coordinately with glial cell line derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells显示文摘 | Ngan E S Shum C K Poon H C Sham M H Garcia-Barcelo M M Lui V C | 2008 | Biochim Biophys Acta2008，1783，： | 1 |
| 6 | Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma:a factorial study显示文摘 | Kwong D L Sham J S Au G K | 2004 | J Clin Oncol2004，22，13： | 1 |
| 7 | A phase Ⅱ study of docetaxel and cisplatin as first-line chemotherapy in patients with metastatic na- sopharyngeal carcinoma显示文摘 | Chua D T Sham J S Au G K | 2005 | Oral Oncol2005，41，6： | 1 |
| 8 | Effects of incubation and spawning water temperature, and salinity on egg development of the spotted grouper (Epinephelus coioides, Serranidae) 显示文摘 | Kawahara S Shams A J Bosta A A | 1997 | Asian Fisheries Science1997，9，4： | 1 |
| 9 | Inverse planning in three-dimensio-nal conformal and intensity-modulated radiotherapy of mid-thoracicoesophageal cancer显示文摘 | Wu V W Sham J S Kwong D L | 2004 | Br J Radiol2004，77，919： | 1 |
| 10 | Impact of Caregiving on Health and Quality of Life : A Comparative Popu- lation-based Study of Caregivers for Elderly Persons and Noncaregivers 显示文摘 | Ho S C Chan A Woo J Chong P and Sham A | 2009 | Journals of Gerontology Series A: Biologi- cal Sciences and Medical Sciences2009，64，： | 1 |
| 11 | X-ray absorption spectra of ruthenium L edges in hexaammine ruthenium (Ⅲ) chloride(Ru(NH3)6Cl3 ) 显示文摘 | Sham T K Brunschwig B S | 1983 | Springer Ser Chem Phys1983，27，： | 1 |
| 12 | No evidence for links between autism, MMR and measles virus显示文摘 | Chen W Landau S Sham P | 2004 | Psychol Med2004，34，： | 1 |
| 13 | A study electronic structure and optical properties of silicon nanowires: Using X-ray excited optical luminescence and X-ray emission spec- troscopy 显示文摘 | Sham T K Naftel S J Kim P S G | 2004 | Phys Rev B2004，70，04： | 1 |
| 14 | Numerical Simulation of Roughness Effects on Flow and Heat Transfer in Microchannels at Slip Flow Regime显示文摘 | Khadem M H Shams M Hossainpour S | 2009 | International Communications in Heat and Mass Transfer2009，36，1： | 1 |
| 15 | Control of regional metastasis after induction chemotherapy and radiotherapy for nasopharyngeal carcinoma显示文摘 | Chua D T Sham J S Wei W I | 2002 | Head Neck2002，24，4： | 1 |
| 16 | lmmunoglobulin A against viral capsid antigen of Epstein-Barr vix'us and indirect mirror examination of the nasopharynx in the detection of the asymptomatic nasopharyngeal carcinoma 显示文摘 | Zong Y S Sham J S Ng M H | 1992 | Cancer1992，69，1： | 1 |
| 17 | Localization, quantification, and activation of platelet- activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FA Kppl 25 显示文摘 | Ahmed A Dearn S Shams M | 1998 | FASEB J1998，12，10： | 1 |
| 18 | Threshold Contrast Ratio and Masking Ability of Porcelain Veneers with High-density Alumina Cores显示文摘 | Chu F C Sham A S Luk H W | 2004 | Int J Prosthodont2004，17，： | 1 |
| 19 | Diagnosis of spon- taneous bacterial peritonitis in children by reagent strips 显示文摘 | Farahmand F Eshagh Roze M Shams S | 2013 | Acta Med Iran2013，51，2： | 1 |
| 20 | Assessment of serum iron and iron deficiency anaemia in sample of pregnant woman at delivery in fran 显示文摘 | Vahidinia AA Shams S | 2004 | Asia Pac J Clin Nutr2004，13，： | 1 |
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