|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-alcoholic fatty liver disease: The diagnosis and management显示文摘Non-alcoholic fatty liver disease(NAFLD) is now the most frequent chronic liver disease that occurs across all age groups and is recognized to occur in 14%-30% of the general population, representing a serious and growing clinical problem due to the growing prevalence of obesity and overweight. Histologically, it resembles alcoholic liver injury but occurs in patients who deny significant alcohol consumption. NAFLD encompasses a spectrum of conditions, ranging from benign hepatocellular steatosisto inflammatory nonalcoholic steatohepatitis, fibrosis, and cirrhosis. The majority of hepatocellular lipids are stored as triglycerides, but other lipid metabolites, such as free fatty acids, cholesterol, and phospholipids, may also be present and play a role in disease progression. NAFLD is associated with obesity and insulin resistance and is considered the hepatic manifestation of the metabolic syndrome, a combination of medical conditions including type 2 diabetes mellitus, hypertension, hyperlipidemia, and visceral adiposity. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies; however, staging the disease requires a liver biopsy. Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and medications appear promising. The aim of this review is to highlight the current information regarding epidemiology, diagnosis, and management of NAFLD as well as new information about pathogenesis, diagnosis and management of this disease. | Shehab M Abd El-Kader Eman M Salah El-Den Ashmawy | 2015 | World Journal of Hepatology2015，7，6： | 44 |
| 2 | Circulating micro RNA, mi R-122 and mi R-221 signature in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma显示文摘AIM: To explore the potential usefulness of serum miR-122 and miR-221 as non-invasive diagnostic markers of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS: This prospective study was conducted on 90 adult patients of both sex with HCV-related chronic liver disease and chronic hepatitis C related HCC. In addition to the 10 healthy control individuals, patients were stratified into; interferon-na?ve chronic hepatitis C(CH)(n = 30), post-hepatitis C compensated cirrhosis(LC)(n = 30) and treatment-naive HCC(n = 30). All patients and controls underwent full clinical assessment and laboratory investigations in addition to the evaluation of the level of serum miR NA expression by RT-PCR.RESULTS: There was a significant fold change in serum mi RNA expression in the different patient groups when compared to normal controls; mi R-122 showed significant fold increasing in both CH and HCC and significant fold decrease in LC. On the other hand, mi R-221 showed significant fold elevation in both CH and LC groups and significant fold decrease in HCC group(P = 0.01). Comparing fold changes in miR NAs in HCC group vs non HCC group(CH and Cirrhosis), there was non-significant fold elevation in miR-122(P = 0.21) and significant fold decreasing in miR-221 in HCC vs non-HCC(P = 0.03). ROC curve analysis for miR-221 yielded 87% sensitivity and 40% specificity for the differentiation of HCC patients from non-HCC at a cutoff 1.82. CONCLUSION: Serum miR-221 has a strong potential to serve as one of the novel non-invasive biomarkers of HCC. | Hassan El-Garem Ayman Ammer Hany Shehab Olfat Shaker Mohammed Anwer Wafaa El-Akel Heba Omar | 2014 | World Journal of Hepatology2014，6，11： | 18 |
| 3 | Vascular depression for radiology: A review of the construct,methodology,and diagnosis显示文摘Vascular depression(VD)as defined by magnetic resonance imaging(MRI)has been proposed as a unique subtype of late-life depression.The VD hypothesis posits that cerebrovascular disease,as characterized by the presence of MRIdefined white matter hyperintensities,contributes to and increases the risk for depression in older adults.VD is also accompanied by cognitive impairment and poor antidepressant treatment response.The VD diagnosis relies on MRI findings and yet this clinical entity is largely unfamiliar to neuroradiologists and is rarely,if ever,discussed in radiology journals.The primary purpose of this review is to introduce the MRI-defined VD construct to the neuroradiology community.Case reports are highlighted in order to illustrate the profile of VD in terms of radiological,clinical,and neuropsychological findings.A secondary purpose is to elucidate and elaborate on the measurement of cerebrovascular disease through visual rating scales and semi-and fully-automated volumetric methods.These methods are crucial for determining whether lesion burden or lesion severity is the dominant pathological contributor to VD.Additionally,these rating methods have implications for the growing field of computer assisted diagnosis.Since VD has been found to have a profile that is distinct from other types of late-life depression,neuroradiologists,in conjunction with psychiatrists and psychologists,should consider VD in diagnosis and treatment planning. | Sara N Rushia Al Amira Safa Shehab Jeffrey N Motter Dakota A Egglefield Sophie Schiff Joel R Sneed Ernst Garcon | 2020 | World Journal of Radiology2020，12，5： | 5 |
| 4 | heterotopic ossification显示文摘 | Shehab D Elgazza AH Collier BD | 2002 | J Nucl Med2002，43，： | 1 |
| 5 | Prevalence and impact of cardiovascular risk factors among patients presenting with acute coronary syndrome in the middle East显示文摘 | El-Menyar A Zubaid M Shehab A | 2011 | Clin Cardiol2011，34，1： | 1 |
| 6 | Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes?显示文摘 | Shehab D Al-Jarallah K Mojiminiyi OA | 2012 | Diabet Med2012，29，1： | 1 |
| 7 | Anterior and posterior nutcracker syndrome:a report on 11 case显示文摘 | Ali-El-Dein B Osman Y Shehab EL-Din AB | 2003 | Transplant Proc2003，35，2： | 1 |
| 8 | Emergency hos- pitalizations for adverse drug events in older Americans 显示文摘 | Budnitz DS Lovegrove MC Shehab N | 2011 | N Engl J Med2011，365，： | 1 |
| 9 | Heterotopic ossification显示文摘 | Shehab D Elgazzar AH Collier BD | 2002 | J Nuei Med2002，43，5： | 1 |
| 10 | Optimising phosphorus removal at the Ann/Arbor wastewater treatment plant 显示文摘 | Shehab O Deininger R Porta F | 1996 | Water Sci Technol1996，34，12： | 1 |
| 11 | Effect of vitamin B12 on chloramphenicol and thiamphenicol used on DNA, with reference to cytogenetic biochemical analysis and pathological studies in rats显示文摘 | Sobhy H M Mohamed E A Shehab G G | 2000 | Egyptian J-Agricult Res2000，78，1： | 1 |
| 12 | Heterotopic ossification显示文摘 | Shehab D Elgazzar AH Collier BD | 2002 | J Nucl Med2002，43，3： | 1 |
| 13 | Biomechanical analysis of a prototype sports bra显示文摘 | Starr C Branson D Shehab R | 2005 | J Text Appa Technol Manag2005，4，3： | 1 |
| 14 | Heterotopic ossification显示文摘 | Shehab D Elgazzar AH Collier BD | 2002 | J Nucl Med2002，43，： | 1 |
| 15 | Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 dia- betes显示文摘 | Shehab D AI Jarallab K Mojiminiyi OA | 2012 | Diabet Med2012，29，1： | 1 |
| 16 | Cognitive and autonomic dysfunction measures in normal controls, white coat and borderline hyperten- sion显示文摘 | Shehab A AbduIle A | 2011 | BMC Cardiovasc Disord2011，113，： | 1 |
| 17 | Workflow authorisation in mediator-free environments显示文摘 | Shehab M Bertino E Ghafoor A | 2006 | Int Journal of Security and Networks2006，1，12： | 1 |
| 18 | Heterotopic ossification 显示文摘 | Shehab D Elgazzar AH Collier BD | 2002 | J Nucl Med2002，43，： | 1 |
| 19 | Acute and chronic sectioning of fifth lumbar spinal nerve has equivalent effects on the primary afferents of sciatic nerve in rat spinal cord 显示文摘 | Shehab S A | 2009 | J Comp Neurol2009，517，4： | 1 |
| 20 | National estimates of emergency department visits for hemor- rhage-related adverse events from clopidogrel plus aspirin and from warfarin显示文摘 | Shehab N Sperling LS Kegler SR | 2010 | Arch Intern Med2010，170，21： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员