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| 1 | Hypoxia potentially promotes Tibetan longevity显示文摘 | Yan Li Ming-Shan Wang Newton O Otecko Wen Wang Peng Shi Dong-Dong Wu Ya-Ping Zhang | 2017 | Cell Research2017，27，2： | 4 |
| 2 | Prohibitin(PHB)interacts with AKT in mitochondria to coordinately modulate sperm motility显示文摘Prohibitin(PHB),an evoluti on arily con served mitochondrial inner membra ne protein,is highly expressed in cells that require strong mitoch on drial function.Recently,we dem on strated that the deleti on of Phb in spermatocytes results in impaired mitochondrial function.In addition,PHB expression in the mitochondrial sheath of human sperm has a significantly negative correlation with mitochondrial reactive oxygen species levels,but a positive one with mitochondrial membrane potential and sperm motility.These results suggest that mitochondrial PHB expression plays a role in sperm motility.However,the mechanism of PHB-mediated regulation of sperm motility remai ns unk nown.Here,we dem on strate for the first time that PHB interacts with protei n kinase B(AKT)and exists in a complex with phospho-PHB(pT258)and phospho-AKT in the mitochondrial sheath of murine sperm,as determined using colocalization and coimmunoprecipitation assays.After blocking AKT activity using wortmannin(a phosphatidylinositol 3-kinase[PI3K]inhibitor),murine sperm have significantly(P<0.05)decreased levels of phospho-PHB(pT258)and the total and progressive motility.Furthermore,significantly(P<0.05)lower levels of phospho-PI3K P85 subunit a+γ(pY199 and pY46)and phospho-AKT(pS473;pT308)are found in sperm from infertile asthenospermic and oligoasthenospermic men compared with no rmospermic subjects,which suggest a reduced activity of the PI3K/AKT pathway in these in fertile subjects.Importantly,these sperm from infertile subjects also have a significantly(P<0.05)lower level of phospho-PHB(pT258).Collectively,our findings suggest that the interaction of PHB with AKT in the mitochondrial sheath is critical for sperm motility,where PHB phosphorylation(pT258)level and PI3K/AKT activity are key regulatory factors. | Xiao-Hui Li Ran-Ran Chai Guo-Wu Chen Ling-Fei Zhang Wen-Jing Tan-Tai Hui-Juan Shi Patricia A Martin-DeLeon Wai-Sum O Hong Chen | 2020 | Asian Journal of Andrology2020，22，6： | 3 |
| 3 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 4 | BRAF and KRAS Mutations in Hyperplastic Polyps and Serrated Adenomas of the Colorectum: Relationship to Histology and CpG Island Methylation Status显示文摘 | Shi Yang Francis A Farraye Charline Mack Oksana Posnik Michael J O’Brien | 2004 | The American Journal of Surgical Pathology2004，，11： | 2 |
| 5 | Modelling low carbon transition and economic impacts under SSPs and RCPs based on GTIMES显示文摘The simulation of global and regional energy system transition and its potential mitigation cost could intuitively reflect the need for earlier climate mitigation actions. To explore the possible transitions of global and regional energy system, this study applied a 14-region energy system model (GTIMES) with scenarios designed using Shared Socio-economic Pathways (SSPs) with Representative Concentration Pathways (RCPs), and detailed depicts the quantification of SSPs trajectories into GTIMES model. Modeling results show that: 1) Global energy-related CO_(2) emissions will reach 37–74 Gt by 2050 under reference scenarios, while they will decrease to 12–14 Gt under higher possibility pathways to reach 2 ℃ target, with ratios of non-fossil fuel round to 42%–46%. 2) Electrification level has to increase noticeably in regional transition with a global average level of about 44% to achieve significant emission reduction. 3) Higher level of mitigation cost would happen with the constraint mitigation target, as well as social and economic trajectories chosen. Therefore, following trajectories of sustainable development is necessary. | YANG Lei SHI Jing-Cheng CHEN Wen-Ying James GLYNN Brian O GALLACHOIR | 2021 | Advances in Climate Change Research2021，12，6： | 2 |
| 6 | Novel protein kinases associated with calcineurin B-like calcium sensors in Ar- abidopsis 显示文摘 | SHI J KIM KN RITZ O | 1999 | Plant Cell1999，11，12： | 1 |
| 7 | Estimating optical flow with cellular neural networks 显示文摘 | SHI B E ROSKA T CHUA L O | 1998 | International Journal of Circuit Theory And Applications1998，26，4： | 1 |
| 8 | Maspin is an angiogenesis inhibitor显示文摘 | Zhang M Volpert O Shi YH | 2000 | Nat Med2000，6，2： | 1 |
| 9 | A test of the growth-limitation theory for alpine tree line formation in evergreen and deciduous taxa of the eastern Himalayas显示文摘 | Shi P K(o)rner C Hoch G | | 0，，22： | 1 |
| 10 | The role of adenosine receptors in the central action of caffeine显示文摘 | Daly JW Shi D Nikodijevic O | 1994 | Pharmacopsychoecologia1994，7，2： | 1 |
| 11 | Visualization of Unwinding activity of duplex RNA by D bpA,a DEAD box helicase, at singlemolecule resolution by a atomic force microscopy显示文摘 | Henn A Medalia O Shi S P | 2001 | Proc Natl Acad Sci USA2001，98，9： | 1 |
| 12 | Maspin is anangiogenesis inhibitor显示文摘 | Zhang M Volpert O Shi Y H | 2000 | Nat Med2000，6，2： | 1 |
| 13 | A pigment-binding protein essential for regulation of photosynthetic light harvesting显示文摘 | Li X P Bjorkman O Shi C Grossman A R Rosenquist M Jansson S Niyogi K K | 2000 | Nature2000，403，6768： | 1 |
| 14 | A vertically moving grid finite element modeling of tidal flow in the Changjiang Estuary, China显示文摘 | SHI Z LI S S and PETERSEN O S | 2003 | International Journal for Numerical Methods in Fluids2003，43，2： | 1 |
| 15 | A quick-and-easy method for estimating switching costs显示文摘 | Shy O | 2002 | International Journal of Industrial Organization2002，20，： | 1 |
| 16 | Maspin is an angiogenesis inhibitor显示文摘 | Zhang M Volpert O Shi YH | 2000 | Nat Med2000，6，2： | 1 |
| 17 | Consumer's decision to shop online: The moderating role of positiveinformational social influence显示文摘 | Lee M K O Shi N Cheung C M K | 2011 | Information Management2011，48，6： | 1 |
| 18 | Utilization of bacterial cellulose in food显示文摘 | Shi Z Zhang Y Phillips G O | 2014 | Food Hydrocolloids2014，35，： | 1 |
| 19 | Bone morphogenetic protein - 6 stimulates gene expression of follicle - stimulating hormone receptor, inhibin/activin beta subunits, and anti - Mullerian hormone in human granulosa cells 显示文摘 | SHI J YOSHINO O OSUGA Y | 2009 | Fertil Steril2009，92，5： | 1 |
| 20 | 3D hierarchical Zn3- (OH)27207 · 2H20 and Zna (704)2 microspheres: Syn- thesis, characterization and photoluminescence显示文摘 | Wang M Shi Y J Jiang G O | 2012 | Mater Res Bu112012，47，： | 1 |
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