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| 1 | Characteristics and predictors of gastric cancer after Helicobacter pylori eradication显示文摘Helicobacter pylori(H. pylori) eradication can reduce gastric cancer. However, gastric cancer still develops after eradication, and cases who received eradication therapy are increasing. In this study, we have reviewed the characteristics and predictors of primary gastric cancer developing after H. pylori eradication. In terms of the characteristics, endoscopic, histologic, and molecular characteristics are reported. Endoscopically, gastric cancer after eradication is often depressedtype and shows a gastritis-like appearance, which sometimes makes the diagnosis difficult. Histologically, most gastric cancer after eradication is intestinal type, and non-neoplastic epithelium, also called epithelium with low-grade atypia, is frequently seen over the tumor, which is presumably the cause of the endoscopic gastritis-like appearance. As for molecular characteristics, some markers, such as Ki67, MUC2, and Wnt5a expression, are lower in cancer from patients in whom H. pylori has been eradicated. In terms of predictors, several Japanese studies have reported that severe endoscopic atrophy at eradication is a risk factor for gastric cancer development. Histologic intestinal metaplasia, especially in the corpus, and long-term use of proton pump inhibitors, are also reported as risk factors for gastric cancer after H. pylori eradication. These studies on the characteristics and predictors of gastric cancer development will become the cornerstone for establishing a novel surveillance program based on the gastric cancer risk stratification specific to H. pylori-eradicated patients. | Satoki Shichijo Yoshihiro Hirata | 2018 | World Journal of Gastroenterology2018，24，20： | 25 |
| 2 | Management of local recurrence after endoscopic resection of neoplastic colonic polyps显示文摘A proportion of neoplastic polyps are incompletely resected, resulting in local recurrence, especially after resection of large polyps or piecemeal resection. Local recurrences that develop after endoscopic resection of intramucosal neoplasms that lacked risk factors for lymph node metastasis or positive vertical margins are usually treated endoscopically. Endoscopic submucosal dissection(ESD) is indicated for local residual or recurrent early carcinomas after endoscopic resection. However, ESD for such recurrent lesions is technically difficult and is typically a lengthy procedure. Underwater endoscopic mucosal resection(UEMR), which was developed in 2012, is suitable for recurrent or residual lesions and reportedly achieves superior en bloc resection rates and endoscopic complete resection rates than conventional EMR. However, a large recurrent lesion is a negative independent predictor of successful en bloc resection and of complete endoscopic removal. We therefore perform UEMR for relatively small(≤ 10-15 mm) recurrent lesions and ESD for larger lesions. | Satoki Shichijo Yoji Takeuchi Noriya Uedo Ryu Ishihara | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，12： | 3 |
| 3 | Antibody to eosinophil cationic protein suppresses dextran sulfate sodium-induced colitis in rats显示文摘AIM: To produce an antibody against rat eosinophil cationic protein (ECP) and to examine the effects of the antibody in rats with dextran sulfate sodium (DSS)-induced colitis.METHODS: An antibody was raised against rat ECP. Rats were treated with 3% DSS in drinking water for 7 d and received the antibody or normal serum. The colons were exarmined histologically and correlated with clinical symptoms.Immunohistochemistry and Western blot analysis were estimated as a grade of inflammation.RESULTS: The ECP antibody stained the activated eosinophils around the injured crypts in the colonic mucosa.Antibody treatment reduced the severity of colonic ulceration and acute clinical symptoms (diarrhea and/or blood-stained stool). Body weight gain was significantly greater and the colon length was significantly longer in anti-ECP-treated rats than in normal serum-treated rats. Expression of ECP in activated eosinophils was associated with the presence of erosions and inflammation. The number of Ki-67-positive cells in the regenerated surface epithelium increased in anti-ECP-treated rats compared with normal serum-treated rats. Western blot analysis revealed reduced expression of macrophage migration inhibitory factor (MIF) in anti-ECP-treated rats.CONCLUSION: Our results indicate that treatment with ECP antibody, improved DSS-induced colitis in rats, possibly by increasing the regenerative activity of the colonic epithelium and downregulation of the immune response,and suggest that anti-ECP may promote intestinal wound healing in patients with ulcerative colitis (UC). | Kazuko Shichijo Kazuya Makiyama Chun-Yang Wen Mutsumi Matsuu Toshiyuki Nakayama Masahiro Nakashima Makoto Ihara Ichiro Sekine | 2005 | World Journal of Gastroenterology2005，11，29： | 2 |
| 4 | High expression of APOBEC3G in patients infected with hepatitis C virus显示文摘 | Komohara Y Yano H Shichijo S | 2006 | J Mol Histol2006，37，89： | 1 |
| 5 | Immediate early response gene X-l, a stress-inducible antiapoptotic gene, encodes cytotoxic T-lymphocyte (CTL) epitopes capable of inducing human leukocyte antigen-A33-restrieted and tumor reactive CTLs in gastric cancer patients显示文摘 | Sasada T Takedatsu H Azuma K Koga M Maeda Y Shichijo S | 2004 | Cancer Res2004，64，： | 1 |
| 6 | An HLA-A3-binding prostate aeid phosphatase-derived peptideean induce CTLs restricted to HLA-A2 and -A24 alleles 显示文摘 | Terasaki Y Shichijo S Niu Y | 2009 | Caneer Immunol Immunother2009，58，11： | 1 |
| 7 | Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity 显示文摘 | Shichijo S Keicho N Long H T | 2004 | Tissue Antigens2004，64，5： | 1 |
| 8 | The effective catalytic synthesis of ester by the condensation of hydroxyl-and nitrile grouing显示文摘 | Naota T Shichijo Y Murahashi S I | 1994 | J Chem Soc:Chem Commun1994，，： | 1 |
| 9 | Phase I clinical studyof a peptide vaccination for hepatitis C virus-infected patients withdifferent human leukocyte antigen-class I -A alleles 显示文摘 | Yutani S Komatsu N Shichijo S | 2009 | CancerSci2009，100，10： | 1 |
| 10 | The effects of anti-asthma drugs on mediator release from cultured human mast cells显示文摘 | Shichijo M Inagaki N Nakai N | 1998 | Clin Exp Allergy1998，28，10： | 1 |
| 11 | Multiple intracellular signaling pathways of the neuropeptide substance P receptor显示文摘 | Ohashi Y Shichijo S | 1992 | J Neurosci Res1992，32，： | 1 |
| 12 | Detection of MAGE-4 protein in sera of patients with head-and-neck squamous-cell carcinoma 显示文摘 | Iwamoto O Nagao Y Shichijo S | 1997 | Int J Cancer1997，70，3： | 1 |
| 13 | Effects of luteolin, quer- cetin and baicalein on immunoglobulin E-mediated mediator re- lease from human cultured mast cells 显示文摘 | Kimata M Shichijo M Miura T | 2000 | Clinical and Experi- mental Allergy2000，30，4： | 1 |
| 14 | How Do Collaborations with Universities Affect Frms' Innovative Performance? The Role of 'Pasteur Scientists' in the Advanced Materials Field 显示文摘 | BABAY SHICHIJO N SEDITA S R | 2009 | Research Policy2009，38，5： | 1 |
| 15 | Identification of SART3-derived peptides capable of inducing HLA-A2-restricted and tumor-specific CTLs in cancer patients with different HLA-A2 subtypes显示文摘 | Shichijo S Miyagi Y | 2000 | Int J Cancer2000，88，4： | 1 |
| 16 | Effects of luteolin, quercetin and baicalein on immunoglohu-lin E-mediated mediator release from human cultured mast cells 显示文摘 | KIMATA M SHICHIJO M MIURA T | 2000 | Clin Exp Allergy2000，30，4： | 1 |
| 17 | Identification of a gene coding for a protein Imssessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphoeytes in cancer patients显示文摘 | Nakan M Shichijo S | 1999 | Cancer Res1999，59，16： | 1 |
| 18 | How do collaborations with universities affect firms′innovative performance?The role of'Pasteur scientists'in the advanced materials field显示文摘 | BABA Y SHICHIJO N SEDITA S R | 2009 | Research Policy2009，38，5： | 1 |
| 19 | Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens 显示文摘 | Imai Y Shichijo S Yamada A | 1995 | Gene1995，160，2： | 1 |
| 20 | Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells显示文摘 | Kimata M Shichijo M Miura T | 2000 | Clin Exp Allergy2000，30，4： | 1 |
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