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82篇 您的检索式：作者名="Shield J P"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	Dustbathing by broiler chickens: A comparison of preference for four different substrates显示文摘	Shields S J J P Garner J A Meneh	2004	Appl Anim Behav Sci2004，87，：	1
3	Blastomere morphology as a predictive measure of fish eggviability显示文摘	Shields R J Brown N P Bromage N R	1997	Aquaculture1997，155，：	1
4	Lung Injury in Acute Pancreatitis: Mechanisms, Prevention, and Therapy显示文摘	Shields C J Winter D C Redmond H P	2002	Curr Opin Crit Care2002，8，2：	1
5	Partial lamellar sclerouvectomy for ciliary body and choroidal tumors显示文摘	SHIELDS J A SHIELDS C L SHAH P	1991	Ophthalmology1991，98，：	1
6	Effect of sand and wood --shavings beddingon the behavior of broiler ehiekens显示文摘	Shields S J J P Garner J A Mench	2005	Poultry Science2005，84，：	1
7	Managing diabetic nephropathy 显示文摘	Shields J Maxwell A P	2010	Clin Med2010，10，5：	1
8	Urinary heparan sulphate proteoglyean excretion is abnormal in insulin dependent diabetes显示文摘	SHIELD J P CARRADUS M STONE J E	1995	Ann Clin Biochem1995，32，6：	1
9	Mycotic pneumonia in mariculture reared green turtles显示文摘	Jacobson E R Gaskin J M Shields R P	1979	Am Vet Med Assoc1979，175，：	1
10	Mutagens from heated Chinese and US cooking oils显示文摘	Shields P G Xu G X Blot W J		0，，：	1
11	Evaluation of the fullerene compound DF-1 as a radiation protector 显示文摘	Brown A P Chung E J Urick M E Shield W P 3rd Sowers A L Thetford A	2010	Radiat Oncol2010，5，：	1
12	Residence time distribution of shallow basin显示文摘	THACKSTON E L SHIELDS J F D SCHROEDER P R	1987	Journal of Environment Engineering1987，113，6：	1
13	Randomized trial of tacrolimus + mycophenolate mofetil or azathioprine versus cyclosporine + mycophenolate mofetil after cadaveric kidney transplantation: results at three years显示文摘	Gonwa T Johnson C Ahsan N Alfrey EJ Halloran P Stegall M Hardy M Metzger R Shield C 3rd Rocher L Scandling J Sorensen J Mulloy L Light J Corwin C Danovitch G Wachs M VanVeldhuisen P Leonhardt M Fitzsimmons WE	2003	Transplantation2003，75，12：	1
14	The effect of gypsy moth metamorphosis on the development of nuclear polyhedrosis virus infection显示文摘	Shields K S Burand J P	1991	J Invert Path1991，57，：	1
15	Resi- dence time distribution of shallow basin显示文摘	THACKSTON E L SHIELDS J F D SCHROEDE P R	1987	Journal of Envi- ronment Engineering1987，113，6：	1
16	An aerobiol0gical framework for alessing cross-pollination in maize 显示文摘	AYLOR D E SCHULTES N P SHIELDS E J	2003	Agricultural and Forest Mete- orology2003，19，：	1
17	Coronary artery calcium, coronary artery disease, and diabetes 显示文摘	MIELKE C H SHIELDS J P BROEMELING L D	2001	Diabetes Res Clin Pract2001，53，1：	1
18	Single-center clinical comparison of two reinforced ureteral access sheaths for retrograde ureteroscopic treatment of urinary lithiasis显示文摘	AYYATHURAI R KANAGARAJAH P SHIELDS J	2012	Int Urol Nephrol2012，44，5：	1
19	Mutagens from heated Chinese and US cooking oils显示文摘	SHIELDS P G XU X G BLOT W J	1995	Journal of the National Cancer Institute1995，87，11：	1
20	Polymer/layered silicate nanocomposites from thermally stable trialkylimidazolium-treated montmorillonite 显示文摘	Gilman J W Awad W H Davis R D Shields J Harris Jr RH Davis C Morgan A B Sutto T E Callahan J Trulove P C DeLong H C	2002	Chem Mater2002，14，：	1

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