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| 1 | 利用单频双程波动方程计算初至走时及其振幅显示文摘通过在频率域双程波动方程模拟算法中加入一个复数频率(实部表示频率,虚部表示衰减因子)压制地震波初至走时之后的能量,从而把初至走时及其振幅的计算问题转换为单一频率波场中最大能量走时和振幅的拾取问题,然后利用单一频率域波场的相位项和振幅项分别计算初至走时及其振幅.本文还提出利用参数分析方法求取最优的复数频率,并给出数值计算例子,将本方法的计算结果与有限差分程函方程初至走时和最大能量走时振幅进行比较,结果表明,该方法具有适应于任意复杂介质和多炮多接收点走时和振幅的计算. | 秦义龙 张中杰 Shin Changsoo Seungwon Ko 陈赟 陈竞一 UkHan | 2005 | 地球物理学报2005，48，2： | 16 |
| 2 | Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms显示文摘BACKGROUND Mesenchymal stem cells(MSCs)are an attractive tool to treat graft-versus-host disease because of their unique immunoregulatory properties.Although human bone marrow-derived MSCs(BM-MSCs)were the most widely used MSCs in cell therapy until recently,MSCs derived from human umbilical cords(UC-MSCs)have gained popularity as cell therapy material for their ethical and noninvasive collection.AIM To investigate the difference in mechanisms of the immunosuppressive effects of UC-MSCs and BM-MSCs.METHODS To analyze soluble factors expressed by MSCs,such as indolamine 2,3-dioxygenase,cyclooxygenase-2,prostaglandin E2 and interleukin(IL)-6,inflammatory environments in vitro were reconstituted with combinations of interferon-gamma(IFN-γ),tumor necrosis factor alpha and IL-1βor with IFN-γalone.Activated T cells were cocultured with MSCs treated with indomethacin and/or anti-IL-10.To assess the ability of MSCs to inhibit T helper 17 cells and induce regulatory T cells,induced T helper 17 cells were cocultured with MSCs treated with indomethacin or anti-IL-10.Xenogeneic graft-versus-host disease was induced in NOG mice(NOD/Shi-scid/IL-2Rγnull)and UC-MSCs or BM-MSCs were treated as cell therapies.RESULTS Our data demonstrated that BM-MSCs and UC-MSCs shared similar phenotypic characteristics and immunomodulation abilities.BM-MSCs expressed more indolamine 2,3-dioxygenase after cytokine stimulation with different combinations of IFN-γ,tumor necrosis factor alpha-αand IL-1βor IFN-γalone.UC-MSCs expressed more prostaglandin E2,IL-6,programmed death-ligand 1 and 2 in the in vitro inflammatory environment.Cyclooxygenase-2 and IL-10 were key factors in the immunomodulatory mechanisms of both MSCs.In addition,UC-MSCs inhibited more T helper 17 cells and induced more regulatory T cells than BM-MSCs.UC-MSCs and BM-MSCs exhibited similar effects on attenuating graft-versus-host disease.CONCLUSION UC-MSCs and BM-MSCs exert similar immunosuppressive effects with different mechanisms involved.These findings suggest that UC-MSCs have distinct immunoregulatory functions and may substitute BM-MBSCs in the field of cell therapy. | Yunejin Song Jung-Yeon Lim Taekyu Lim Keon-Il Im Nayoun Kim Young-Sun Nam Young-Woo Jeon Jong Chul Shin Hyun Sun Ko In Yang Park Seok-Goo Cho | 2020 | World Journal of Stem Cells2020，12，9： | 4 |
| 3 | A MEMS ultrasound stimulation system for modulation of neural circuits with high spatial resolution in vitro显示文摘Neuromodulation by ultrasound has recently received attention due to its noninvasive stimulation capability for treating brain diseases.Although there have been several studies related to ultrasonic neuromodulation,these studies have suffered from poor spatial resolution of the ultrasound and low repeatability with a fixed condition caused by conventional and commercialized ultrasound transducers.In addition,the underlying physics and mechanisms of ultrasonic neuromodulation are still unknown.To determine these mechanisms and accurately modulate neural circuits,researchers must have a precisely controllable ultrasound transducer to conduct experiments at the cellular level.Herein,we introduce a new MEMS ultrasound stimulation system for modulating neurons or brain slices with high spatial resolution.The piezoelectric micromachined ultrasonic transducers(pMUTs)with small membranes(submm membranes)generate enough power to stimulate neurons and enable precise modulation of neural circuits.We designed the ultrasound transducer as an array structure to enable localized modulation in the target region.In addition,we integrated a cell culture chamber with the system to make it compatible with conventional cell-based experiments,such as in vitro cell cultures and brain slices.In this work,we successfully demonstrated the functionality of the system by showing that the number of responding cells is proportional to the acoustic intensity of the applied ultrasound.We also demonstrated localized stimulation capability with high spatial resolution by conducting experiments in which cocultured cells responded only around a working transducer. | Jungpyo Lee Kyungmin Ko Hyogeun Shin Soo-Jin Oh CJustin Lee Namsun Chou Nakwon Choi Min Tack Oh Byung Chul Lee Seong Chan Jun Il-Joo Cho | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 4 | A case of a duodenal duplication cyst presenting as melena显示文摘Duodenal duplication cysts are benign rare congenital anomalies reported mainly in the pediatric population,but seldom in adults.Symptoms depend on the type and location and can present as abdominal pain,distension,dysphagia or dyspepsia.They have been reported to be responsible for duodenal obstruction,pancreatitis and,in rare cases,gastrointestinal bleeding.We present a case of a duodenal duplication cyst in a 43-year-old man presenting as melena.Initial gastroduodenoscopy and colonoscopy did not reveal any bleeding focus.However,the patient began passing melena after 3 d,with an acute decrease in hemoglobin levels.Subsequent studies revealed a duplication cyst in the second portion of the duodenum which was surgically resected.Histology revealed a duodenal duplication cyst consisting of intestinal mucosa.There was no further bleeding and the patient recovered completely.In rare cases,duodenal duplication cysts might cause gastrointestinal bleeding and should be included in the differential diagnosis. | Seung Yeon Ko Sun Hye Ko Sungeun Ha Mi Sung Kim Hyang Mi Shin Myong Ki Baeg | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 5 | Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats显示文摘Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism. Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death. | Sung Eun Kim ll Gyu Ko Mal Soon Shin Chang Ju Kim Young Gwan Ko Hanjin Cho | 2012 | Neural Regeneration Research2012，7，22： | 2 |
| 6 | Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue显示文摘在多细胞的有机体,控制预定和不对称的细胞部门(ACD ) 的程度为正确 patterning 是关键的。在在 Arabidopsis thaliana 的 embryonic 以后根开发期间,地面织物(GT ) 成熟包含内皮的另外的 ACD,它产生二不同纸巾:内皮(内部) 并且中间的外皮(外部) 。这被报导了 abscisic 酸(骆驼毛的织物) 和赤霉素(GA ) 小径涉及中间的外皮(MC ) 形成。然而,在 GT 成熟期间位于在骆驼毛的织物和 GA 之间的相互作用下面的分子的机制仍然保持大部分未知。通过 transcriptome 分析,我们识别了一以前 uncharacterized C 2 H 2-type 锌手指基因,其表情被 GA 和骆驼毛的织物调整,因此命名的 GAZ (GA- 和骆驼毛的织物应答的锌手指) 。幼苗宫外地 overexpressing GAZ (GAZ 公牛) 在 MC 形成期间对骆驼毛的织物和 GA 敏感,而 GAZ-SRDX 和 RNAi 幼苗显示了相反的显型。另外,我们的结果显示 GAZ 涉及骆驼毛的织物和 GA 动态平衡的 transcriptional 规定。与那件骆驼毛的织物和 GA 协调控制预定 MC 形成的以前的研究一致,我们也证实了在骆驼毛的织物和 GA 之间的唯一的相互影响并且识别了在 Arabidopsis 根的 GT 成熟期间衔接二条荷尔蒙小径的因素和规章的网络。 | Shin Ae Lee Sejeong Jang Eun Kyung Yoon Jung-Ok Heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-Eun Choe Jae Bok Heo Chian Kwon Jae-Heung Ko Yong-Sic Hwang Jun Lim | 2016 | Molecular Plant2016，9，6： | 2 |
| 7 | Chorea-ballism associated with nonketotic hyperglycaemia or diabetic ketoacidosis: Characteristics of 25 patients in Korea显示文摘 | Seung-Hwan Lee Jeong-Ah Shin Ji-Hyun Kim Jang-Won Son Kang-Woo Lee Seung-Hyun Ko Seung-Ho Yang Byung Chul Son Yu-Bae Ahn | 2011 | Diabetes Research and Clinical Practice2011，，2： | 2 |
| 8 | Modeling and implementation of tandem polymer solar cells using wide-bandgap front cells显示文摘Tandem device architectures offer a route to greatly increase the maximum possible power conversion efficiencies(PCEs)of polymer solar cells,however,the complexity of tandem cell device fabrication(such as selecting bandgaps of the front and back cells,current matching,thickness,and recombination layer optimization)often result in lower PCEs than are observed in single-junction devices.In this study,we analyze the influence of front cell and back cell bandgaps and use transfer matrix modeling to rationally design and optimize effective tandem solar cell structures before actual device fabrication.Our approach allows us to estimate tandem device parameters based on known absorption coefficients and open-circuit voltages of different active layer materials and design devices without wasting valuable time and materials.Using this approach,we have investigated a series of wide bandgap,high voltage photovoltaic polymers as front cells in tandem devices with PTB7-Th as a back cell.In this way,we have been able to demonstrate tandem devices with PCE of up to 12.8%with minimal consumption of valuable photoactive materials in tandem device optimization.This value represents one of the highest PCE values to date for fullerene-based tandem solar cells. | Seo-Jin Ko Hyosung Choi Quoc Viet Hoang Chang Eun Song Pierre-Olivier Morin Jungwoo Heo Mario Leclerc Sung Cheol Yoon Han Young Woo Won Suk Shin Bright Walker Jin Young Kim | 2020 | Carbon Energy2020，2，1： | 2 |
| 9 | Oleanolic acid attenuates MK-801-induced schizophrenia-like behaviors in mice显示文摘 | Se Jin Park Younghwa Lee Hee Kyong Oh Hyung Eun Lee Younghwan Lee Sang Yoon Ko Boseong Kim Jae Hoon Cheong Chan Young Shin Jong Hoon Ryu | 2014 | Neuropharmacology2014，，： | 2 |
| 10 | Single row rotator cuff repair with modified technique显示文摘Rotator cuff tear is a common medical condition.We introduce various suture methods that can be used for arthroscopic rotator cuff repair,review the single row rotator cuff repair method with modified technique,and introduce the Ulsan-University(UU)stich.We compare the UU stitch with the modified Mason-Allen(MA)suture method.The UU stitch configuration is a simple alternative to the modified MA suture configuration for rotator cuff repair. | Sang-Hun Ko Seung-Myeong Shin | 2012 | World Journal of Orthopedics2012，3，12： | 2 |
| 11 | Effect of Mg17Al12 precipitate on Corrosion behavior of AZ91D magnesium alloy 显示文摘 | KO Y J YIM C D LIM J D SHIN K S | 2003 | Mater Science Forum2003，，： | 1 |
| 12 | Tandem Synthesis of Photoactive Benzodifuran Moieties in the Formation of Microporous Organic Networks显示文摘 | Narae Kang Ji Hoon Park Kyoung Chul Ko Jiseul Chun Eunchul Kim Hee‐Won Shin Sang Moon Lee Hae Jin Kim Tae Kyu Ahn Jin Yong Lee Seung Uk Son | 2013 | Angew. Chem. Int. Ed2013，，24： | 1 |
| 13 | Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice显示文摘 | Ko J Shin SM Oh YM | 2004 | Oncogene2004，23，10： | 1 |
| 14 | Stable but nondissipative water显示文摘 | Song O Y Shin H Ko H S | 2005 | ACM Transactions on Graphics2005，24，1： | 1 |
| 15 | Effects of temperature and initial microstructure on the equal channel angular pressing of Ti-6Al-4V alloy 显示文摘 | KO Y G JUNG W S SHIN D H | 2003 | Scripta Materialia2003，48，2： | 1 |
| 16 | Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes显示文摘 | Nam KO Kang H Shin SM | 2005 | J Immunol2005，174，4： | 1 |
| 17 | An adequate level of training for technical competence in screening and diagnostic colonoscopy: a prospective multicenter evaluation of the learning curve显示文摘 | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Young Hwangbo Won Ho Kim Dong Hun Park Sang Kil Lee Cheol Hee Park Il-Hyun Baek Dong Il Park Seun-Ja Park Jeong-Seon Ji Byung-Ik Jang Yoon-Tae Jeen Jeong Eun Shin Jeong-Sik Byeon Chang-Soo Eun D | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 18 | Esophagorespiratory fistula:long-term results of palliative treatment with covered expandable metallic stent8 in 61 patients显示文摘 | Shin J H Song H Y Ko G Y | 2004 | Radiology2004，232，1： | 1 |
| 19 | BreastMRI forevaluating patientswithmetastatic axillary lymph node and initially nega- tive mammography and sonography 显示文摘 | Ko E Y HanA P Shin JH | 2007 | Korean JRadio2007，8，5： | 1 |
| 20 | Treatment of tracheobronchial obstruction with a polytetrafluoroethylene-covered retrievable expandable nitinol stent 显示文摘 | Shin JH Song HY Ko GY | 2006 | J Vasc Interv Radiol2006，17，： | 1 |
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