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| 1 | Oxidative stress and antioxidants in hepatic pathogenesis显示文摘Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases,including hepatocellular carcinoma (HCC). The HBV encod-ed proteins,hepatitis B virus X protein and preS,appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress,which can damage cellular molecules like lipids,proteins,and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants,such as curcumin,silymarin,green tea,and vitamins C and E,can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis,focusing upon HBV and alcohol,and suggests antioxidant therapeutic approaches. | Hye-Lin Ha Hye-Jun Shin Mark A Feitelson Dae-Yeul Yu | 2010 | World Journal of Gastroenterology2010，16，48： | 18 |
| 2 | Verification on Spray Simulation of a Pintle Injector for Liquid Rocket Engine显示文摘The pintle injector used for a liquid rocket engine is a newly re-attracted injection system famous for its wide throttle ability with high efficiency. The pintle injector has many variations with complex inner structures due to its moving parts. In order to study the rotating flow near the injector tip, which was observed from the cold flow experiment using water and air, a numerical simulation was adopted and a verification of the numerical model was later conducted. For the verification process, three types of experimental data including velocity distributions of gas flows, spray angles and liquid distribution were all compared using simulated results. The numerical simulation was performed using a commercial simulation program with the Eulerian multiphase model and axisymmetric two dimensional grids. The maximum and minimum velocities of gas were within the acceptable range of agreement, however, the spray angles experienced up to 25% error when the momentum ratios were increased. The spray density distributions were quantitatively measured and had good agreement. As a result of this study, it was concluded that the simulation method was properly constructed to study specific flow characteristics of the pintle injector despite having the limitations of two dimensional and coarse grids. | Min Son Kijeong Yu Kanmaniraja Radhakrishnan Bongchul Shin Jaye Koo | 2016 | Journal of Thermal Science2016，25，1： | 16 |
| 3 | Early prediction of myocardial viability after acute myocardial infarction by two-dimensional speckle tracking imaging显示文摘BackgroundIdentifying 心肌的坏死和在尖锐心肌的梗塞(AMI ) 的心肌的生存能力的度的 transmural 程度临床上是重要的。这研究的目的是用二维的点缀追踪估计心肌的生存能力在有 AMI.Methods2D-STI 的病人的成像( 2D-STI )与 AMI 在 30 个病人在主要经皮的冠的干预(一种总线标准)以后在起始的表示,三天,和六个月被执行,谁有左前面的下降冠的动脉(男孩)犯人损害。另外,有最小的 stenotic 损害的 20 个病人(<30% 狭窄) 也在控制组在冠的 angiography 上被包括。在六月 dobutamine, echocardiography 在 LAD 领土的七个片断为生存能力评价被执行。根据墙运动反常的恢复,片断作为可行被分类或 131 个片断全部的 non-viable.ResultsA 是可行的,并且 44 是不能生存的。Multivariate 分析在山峰揭示了可行、不能生存的片断之间的重要差别收缩紧张,山峰在起始的表示的收缩紧张率,和山峰在主要一种总线标准以后的收缩紧张率三天。在这些之中,起始的山峰收缩紧张率为心肌的生存能力有最高预兆的价值(危险比率:31.22, P <0.01 ).Conclusions2D-STI 为估计收缩紧张率可能是的心肌的生存能力,和山峰是可行的在有 AMI 的病人的心肌的生存能力的最可靠的预言者。 | Jong Shin Woo Tae-Kyung Yu Woo-Shik Kim Kwon Sam Kim Weon Kim | 2015 | Journal of Geriatric Cardiology2015，12，5： | 14 |
| 4 | Severe acute pancreatitis due to tamoxifen-induced hypertriglyceridemia with diabetes mellitus显示文摘The side effects of tamoxifen are generally mild, including the effect on lipoprotein metabolism. However, there are few cases of severe tamoxifen induced hypertriglyceridemia. Hypertriglyceridemia is a marked risk factor for acute pancreatitis and approximately 2% to 5% of cases of acute pancreatitis are related to drugs. We report on tamoxifen-induced hypertriglyceridemia and acute pancreatitis in a 40 years old woman with type 2 diabetes mellitus occurred by dexamethasone. She was treated with insulin infusion and fenofibrate, and goserelin acetate was started instead of tamoxifen after discharge from the hospital. Also, probable pathogenic hypotheses about the correlation between tamoxifen and dexamethasone induced type 2 diabetes mellitus on severe acute pancreatitis are provided. Clinicians should take care of risks of severe acute pancreatitis on using tamoxifen, especially for patients with dexamethasone induced diabetes mellitus. These individuals should undergo pre-post tamoxifen lipid screening and careful history taking of drugs, including dexamethasone. | Young Ae Kim Sol Lee Ji Woong Jung Yu Jin Kwon Gyeong Bok Lee Dong Gue Shin Sang Su Park Jin Yun Yong-Seog Jang Dong Hui Cho | 2014 | Chinese Journal of Cancer Research2014，26，3： | 12 |
| 5 | Recent Progress and Development in Extrusion of Rare Earth Free Mg Alloys: A Review显示文摘Mg and its alloys are the lightest structural metals available and are extremely attractive for applications as lightweight components, particularly in the automobile, electronic, and aerospace industries. The global market for wrought Mg alloys has steadily expanded over the past decade. And numerous studies have been carried out to meet this increasing demand of high-performance Mg alloys. However, Mg extrusion alloys have had a very limited usage so far. To overcome existing industrial challenges, one desirable approach is the development of low-cost rare earth(RE) free Mg extrusion alloys with superior mechanical properties. This review will introduce the recent research highlights in the extrusion of Mg alloys, specifi cally focusing on low-cost RE-free Mg alloy. The results from both the literature and our previous study are summarized and critically reviewed. Several aspects of RE-free Mg extrusion alloys are described in detail:(1) novel alloying designs including Mg–Al-, Mg–Zn-, Mg–Ca-, Mg–Sn-, and Mg–Bi-based alloys,(2) advanced extrusion techniques, and(3) extrusion-related severe plastic deformation(SPD) processing. Accordingly, considering the large gap in mechanical properties between the current RE-free Mg alloys and high-performance aluminum alloys, new alloy design, processing route control, and recommendations for future research on RE-free Mg extrusion alloys are also proposed. We hope this review will not only off er insightful information regarding the extrusion of RE-free Mg alloys but also inspire the development of new Mg extrusion technologies. | Shuai-Ju Meng Hui Yu Shao-Da Fan Qi-Zhi Li Sung Hyuk Park Joung Sik Suh Young Min Kim Xiao-Long Nan Ming-Zhe Bian Fu-Xing Yin Wei-Min Zhao Bong Sun You Kwang Seon Shin | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，2： | 6 |
| 6 | Prevalence of upper gastrointestinal bleeding risk factors among the general population and osteoarthritis patients显示文摘AIM To assess the prevalence of possible risk factors of upper gastrointestinal bleeding(UGIB) and their agegroup specific trend among the general population and osteoarthritis patients.METHODS We utilized data from the National Health InsuranceService that included claims data and results of the national health check-up program. Comorbid conditions(peptic ulcer, diabetes, liver disease, chronic renal failure, and gastroesophageal reflux disease), concomitant drugs(aspirin, clopidogrel, cilostazol, non-steroidal anti-inflammatory drugs, steroid, anticoagulants, and SSRI), personal habits(smoking, and alcohol consumption) were considered as possible UGIB risk factors. We randomly imputed the prevalence of infection in the data considering the age-specific prevalence of Helicobacter pylori(H. pylori) infection in Korea. The prevalence of various UGIB risk factors and the age-group specific trend of the prevalence were identified. Prevalence was compared between osteoarthritis patients and others.RESULTS A total of 801926 subjects(93855 osteoarthritis patients) aged 20 and above were included. The prevalence of individual and concurrent multiple risk factors became higher as the age increased. The prevalence of each comorbid condition and concomitant drug were higher in osteoarthritis patients. Thirty-five point zero two percent of the overall population and 68.50% of osteoarthritis patients had at least one or more risk factors of UGIB. The prevalence of individual and concurrent multiple risk factors in younger age groups were also substantial. Furthermore, when personal habits(smoking, and alcohol consumption) and H. pylori infection were included, the prevalence of concurrent multiple risk factors increased greatly even in younger age groups.CONCLUSION Prevalence of UGIB risk factors was high in elderly population, but was also considerable in younger population. Patient with osteoarthritis was at higher UGIB risk than those without osteoarthritis. Physicians s h o u ld c o n s id e r in d i v i d u a li z e d r i s k a s s e s s m e n t regardless of age when prescribing drugs or performing procedures that may increase the risk of UGIB, and take necessary measures to reduce modifiable risk factors such as H. pylori eradication or lifestyle counseling. | Sang Hyuck Kim Jae Moon Yun Chong Bum Chang Heng Piao Su Jong Yu Dong Wook Shin | 2016 | World Journal of Gastroenterology2016，22，48： | 6 |
| 7 | Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice显示文摘Pathological bone loss is caused by an imbalance between bone formation and resorption.The bone microenvironments are hypoxic,and hypoxia-inducible factor (HIF) is known to play notable roles in bone remodeling.However,the relevant functions of HIF-2α are not well understood.Here,we have shown that HIF-2α deficiency in mice enhances bone mass through its effects on the differentiation of osteoblasts and osteoclasts.In vitro analyses revealed that HIF-2α inhibits osteoblast differentiation by targeting Twist2 and stimulates RANKL-induced osteoclastogenesis via regulation of Traf6.In addition,HIF-2α appears to contribute to the crosstalk between osteoblasts and osteoclasts by directly targeting RANKL in osteoprogenitor cells.Experiments performed with osteoblast- and osteoclast-specific conditional knockout mice supported a role of HIF-2α in this crosstalk.HIF-2α deficiency alleviated ovariectomy-induced bone loss in mice,and specific inhibition of HIF-2α with ZINC04179524 significantly blocked RANKLmediated osteoclastogenesis.Collectively,our results suggest that HIF-2α functions as a catabolic regulator in bone remodeling,which is critical for the maintenance of bone homeostasis. | Sun Young Lee Ka Hyon Park Hyung-Gu Yu Eunbyul Kook Won-Hyun Song Gyuseok Lee Jeong-Tae Koh Hong-In Shin Je-Yong Choi Yun Hyun Huh Je-Hwang Ryu | 2019 | Bone Research2019，7，2： | 5 |
| 8 | Paclitaxel and curcumin co-bound albumin nanoparticles having antitumor potential to pancreatic cancer显示文摘Albumin nanoparticles are considered to be an effective way to load water-insoluble anticancer drugs and target tumors via the gp60-mediated pathway. Herein, we fabricated an albumin nanoparticle formulation for co-loading paclitaxel(PTX) and curcumin(CCM), both of which have prominent anticancer efficacy, via nanoparticle albumin-bound(NabTM) technology using high-pressure homogenization. The PTX/CCM co-bound albumin nanoparticles(PTX/CCM Alb-NPs) had a slightly greater particle size of ~250 nm than that of plain PTX AlbNPs and CCM Alb-NPs(~234 and ~134 nm, respectively), with spherical surface morphology and stable size maintenance. However, the zeta potential of PTX/CCM Alb-NPs(ca.-30 mV)was not significantly different from that of PTX or CCM Alb-NPs. The loaded PTX and CCM were released gradually from the PTX/CCM Alb-NPs over ~24 h(97.7 ± 1.7% and 76.2 ± 0.5%,respectively). Furthermore, PTX/CCM Alb-NPs appeared to be efficiently internalized into Mia Paca-2 cells and exhibited a 71% increased IC50 versus PTX Alb-NPs in terms of cytotoxicity to Mia Paca-2 cells. These results suggest that PTX/CCM Alb-NPs are a new potential anticancer agent for combination therapy. | Bomi Kim Changkyu Lee Eun Seong Lee Beom Soo Shin Yu Seok Youn | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，6： | 4 |
| 9 | Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing显示文摘Gastric cancer(GC) is a highly heterogeneous disease with multiple cellular types and poor prognosis.However, the cellular evolution and molecular basis of GC at the individual intra-tumor level has not been well demonstrated. We performed single-cell whole exome sequencing to detect somatic singlenucleotide variants(SNVs) and significantly mutated genes(SMGs) among 34 tumor cells and 9 normal cells from a patient with GC. The Complete Prediction for Protein Conformation(CPPC) approach directly predicting the folding conformation of the protein 3D structure with Protein Folding Shape Code, combined with functional experiments were used to confirm the characterization of mutated SMGs in GC cells. We identified 201 somatic SNVs, including 117 non-synonymous mutations in GC cells. Further analysis identified 24 significant mutated genes(SMGs) in single cells, for which a single amino acid change might affect protein conformation. Among them, two genes(CDC27 and FLG) that were mutated only in single cells but not in the corresponding tumor tissue, were recurrently present in another GC tissue cohort, and may play a potential role to promote carcinogenesis, as confirmed by functional characterization. Our findings showed a mutational landscape of GC at intra-tumor level for the first time and provided opportunities for understanding the heterogeneity and individualized target therapy for this disease. | Lihua Peng Rui Xing Dongbing Liu Li Bao Wenxiang Cheng Hongyi Wang Yuan Yu Xiaofeng Liu Lu Jiang Yan Wu Zhongxue An Qiaoyi Liang Ryong Nam Kim Young Kee Shin Huanming Yang Jian Wang Jun Yu Xiuqing Zhang Xun Xu Jiaan Yang Kui Wu Shida Zhu Youyong Lu | 2019 | Science Bulletin2019，64，4： | 3 |
| 10 | Pancreatic duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy显示文摘The patient was a 30-year-old female who had undergone excision of the extrahepatic bile duct and Rouxen-Y hepaticojejunostomy for congenital biliary dilatation at the age of 7.Thereafter,she suffered from recurrent acute pancreatitis due to pancreaticobiliary maljunction and received subtotal stomach-preserving pancreaticoduodenectomy.She developed a pancreatic fistula and an intra-abdominal abscess after the operation.These complications were improved by percutaneous abscess drainage and antibiotic therapy.How ever,upper abdominal discomfort and the elevation of serum pancreatic enzymes persisted due to stenosis from the pancreaticojejunostomy.Because we could not accomplish dilation of the stenosis by endoscopic retrograde cholangiopancreatography,we tried an endoscopic ultrasonography(EUS) guided rendezvous technique for pancreatic duct drainage.After transgastric puncture of the pancreatic duct using an EUS-fine needle aspiration needle,the guidewire was inserted into the pancreatic duct and finally reached to the jejunum through the stenotic anastomosis.We changed the echoendoscope to an oblique-viewing endoscope,then grasped the guidewire and withdrew it through the scope.The stenosis of the pancreaticojejunostomy was dilated up to 4 mm,and a pancreatic stent was put in place.Though the pancreatic stent was removed after three months,the patient remained symptomfree.Pancreatic duct drainage using an EUS-guided rendezvous technique was useful for the treatment of a stenotic pancreaticojejunostomy after pancreaticoduodenectomy. | Tetsuya Takikawa Atsushi Kanno Atsushi Masamune Shin Hamada Eriko Nakano Shin Miura Hiroyuki Ariga Jun Unno Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Hiroshi Yoshida Yu Katayose Michiaki Unno Tooru Shimosegawa | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 11 | Characterization of CD8+CD57+ T cells in patients wit acute myocardial infarction显示文摘 | Hee Tae Yu Jong-Chan Youn Jino Lee Seunghyun Park Ho-Seok Chi Jungsul Lee Chulhee Choi Sungha Park Donghoon Choi Jong-Won Ha Eui-Cheol Shin | 2015 | Cellular & Molecular Immunology2015，12，4： | 3 |
| 12 | Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial显示文摘 | Sung Hoon Noh Sook Ryun Park Han-Kwang Yang Hyun Cheol Chung Ik-Joo Chung Sang-Woon Kim Hyung-Ho Kim Jin-Hyuk Choi Hoon-Kyo Kim Wansik Yu Jong Inn Lee Dong Bok Shin Jiafu Ji Jen-Shi Chen Yunni Lim Stella Ha Yung-Jue Bang | 2014 | Lancet Oncology2014，，12： | 3 |
| 13 | Development of seeder for mixed planting of corn and soybeans显示文摘Corn and soybeans should be sown between 5 cm and 10 cm apart in mixed cultivation to increase protein content and improve productivity of the forage.However,existing sowers cannot plant at intervals of less than 20 cm.Consequently,mixed cultivation of corn and soybeans is currently performed by first sowing corn seeds with a tractor and then manually planting soybean seeds.This method results in irregular intervals between the seeds,it is laborious and time consuming.This study aimed at developing a seeder that can simultaneously,precisely and efficiently plant corn and soybean.The geometrical and rheological properties of corn and soybeans were initially measured.The seed conveying equipment were designed using the EDEM software.The sowing interval between seeds,depth of soil over planted seed,and sowing performance were analyzed.The EDEM simulation results indicated that a 6-mm-wide and 3-mm-deep grooved seed-delivering roller had the highest particle mobility of the designs considered,with a 2.5%misplanting rate.A performance test showed that no misplanting occurred in the sections sowed with soybean seeds at a seeding interval that averaged 32 mm(321 seeds sown in 10 m)and that misplanting occurred in one section sowed with corn at a seeding interval that averaged 247 mm(40 seeds sown over 10 m).The sowing efficiency for both corn and soybeans was found to be 0.42 h/hm2.The average depth of soil over seed was 32.7 mm for soybean and 39.7 mm for corn.These average depths are within the stipulated range for the depth of soil over seed,which is 5 to 10 times the seed size.This study developed an efficient seeding machine that can simultaneously plant soybean and corn precisely,consequently improving forage yield and saving man-hours. | Seung Min Woo Daniel Dooyum Uyeh Moon Sang Sagong Yu Shin Ha | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 3 |
| 14 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan显示文摘 | Chi–Ling Chen Hwai–I. Yang Wei–Shiung Yang Chun–Jen Liu Pei–Jer Chen San–Lin You Li–Yu Wang Chien–An Sun Sheng–Nan Lu Ding–Shin Chen Chien–Jen Chen | 2008 | Gastroenterology2008，，1： | 3 |
| 15 | Easy calibration method of vision system for in-situ measurement of strain of thin films显示文摘An easy calibration method was presented for in-situ measurement of displacement in the order of nanometer during micro-tensile test for thin films by using CCD camera as a sensing device. The calibration of the sensing camera in the system is a central element part to measure displacement in the order of nanometer using images taken with the camera. This was accomplished by modeling the optical projection through the camera lens and relative locations between the object and camera in 3D space. A set of known 3D points on a plane where the film is located on is projected to an image plane as input data. These points, known as a calibration points, are then used to estimate the projection parameters of the camera. In the measurement system of the micro-scale by CCD camera, the calibration data acquisition and one-to-one matching steps between the image and 3D planes need precise data extraction procedures and repetitive user's operation to calibrate the measuring devices. The lack of the robust image feature extraction and easy matching prevent the practical use of these methods. A data selection method was proposed to overcome these limitations and offer an easy and convenient calibration of a vision system that has the CCD camera and the 3D reference plane with calibration marks of circular type on the surface of the plane. The method minimizes the user's intervention such as the fine tuning of illumination system and provides an efficient calibration method of the vision system for in-situ axial displacement measurement of the micro-tensile materials. | Jun-Hyub PARK Dong-Joong KANG Myung-Soo SHIN Sung-Jo LIM Son-Cheol YU Kwang-Soo LEE Jong-Eun HA Sung-Hoon CHOA | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 3 |
| 16 | Risk Factors for Progression from Cytomegalovirus Viremia to Cytomegalovirus Disease after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘 | Ji Eun Jang Shin Young Hyun Yun Deok Kim Sul Hee Yoon Doh Yu Hwang Soo Jeong Kim Yuri Kim Jin Seok Kim June-Won Cheong Yoo Hong Min | 2012 | Biology of Blood and Marrow Transplantation2012，，6： | 2 |
| 17 | Polymeric micelle nanocarriers in cancer research显示文摘Amphiphilic 块共聚物(ABC ) 集合进球形的 nanoscopic 超分子的核心 / 壳 nanostructure 称为广泛地为糟糕水溶性的 anticancer 代理人作为血管注射剂 nanocarrier 被研究了的聚合 micelle。这篇评论文章的目的是向临床的试用在药交货的领域里更新进步,加亮在为由提高的渗透和保留(EPR ) 效果指向的药增溶,减少的离开目标毒性和肿瘤使用的聚合微粒的进展。聚合微粒在血和药版本率在稳定性变化,并且因此在药交货起不同却关键的作用。为静脉内(IV ) 注入,聚合微粒在血拆卸并且很快释放象 paclitaxel 那样的糟糕水溶性的 anticancer 代理人相对存在增溶的代理人被用于药增溶,安全和毒性减小的不同可能性,例如, Cremophor EL。稳定的聚合微粒在血和还原剂分发是长传播的到非目标织物,降低离开目标毒性。进一步,他们在鼠科的肿瘤模型参予 EPR 效果。在是的概括、聚合微粒行为为糟糕水溶性的 anticancer 代理人的血管注射剂 nanocarriers,完成减少的毒性并且由 EPR 效果指向肿瘤。 | Dae Hwan Shin Yu Tong Tam Glen S. Kwon | 2016 | Frontiers of Chemical Science and Engineering2016，10，3： | 2 |
| 18 | Molecular genetic evidence of Y chromosome loss in male patients with hematological disorders显示文摘在那里的背景是 Y 染色体损失是否是年龄的连续争论相关现象或显示一个恶意的变化的一个细胞发生的标记。试图在特定的病人调查 Y 染色体损失的频率以便决定现在是否是年龄的这研究联系了现象或显示恶意的 change.Methods 的一个细胞发生的标记有 59 岁( 22-95 年)的中部的年龄的 592 个男病人在这被包括学习。这些病人被划分成二个组:学习组包括有的 hematological 混乱包括了 myeloproliferative 混乱( MPD )的 237 个病人, myelodysplastic 症候群( MDS ),尖锐 myeloid 白血病( AML ),长期的 myeloid 白血病(电流型逻辑),多重骨髓瘤(公里),并且淋巴瘤和控制组织没有 hematological 疾病的证据包括 355 个病人。在用为染色体 X 或 Y 的着丝点特定的 DNA 探针的 situ 杂交的常规 cytogenetics 和荧光根据我们 24 从有 hematological 混乱(10.1%) 的 237 个病人有的标准实验室 protocols.Results 被执行 Y 染色体损失。这些 24patients , 2 个病人有 AML (5.0%所有 AML 病人), 2 个病人有电流型逻辑(5.7%所有电流型逻辑病人), 2 个病人有 MPD (8.0%所有 MPD 病人), 3 个病人有公里(10.0%所有公里病人), 5 个病人有淋巴瘤(10.6%所有淋巴瘤病人), 10 个病人有 MDS (16.7%所有 MDS 病人)。21 作为唯一的异例并且留下从这 24 个病人有 Y 染色体的损失三有伴有 otherstructural 变化由常规细胞发生的分析检测了的 Y 染色体的损失。在 situ 杂交(鱼) 的荧光分析证实了平淡的细胞发生的结果。所有 24 个病人与房间的 17.5%-98.5% 的一个范围有 Y 染色体的损失。二个病人,有 AML 的病人和有电流型逻辑的另外一个。结果在起始的诊断显示出 Y 染色体的损失但是正常 46, XY karyotype 在宽恕期间。仅仅, 9 从没有 hematological 疾病的证据的 355 个病人(2.5%) 有 Y 染色体损失,在他们之中 7 个病人有心血管的疾病, 2 个病人有肾疾病。在有 hematological 混乱或没有用统计分析的 hematological 疾病的证据的病人的 Y 染色体损失的发生的比较出现了一统计上现在的学习表明了的意义差别( P0.05 ) .Conclusions 没有 hematological 混乱, Y 染色体损失的频率比在病人在有 hematological 混乱的病人是显著地更高的,它显示 Y 染色体的损失与一个肿瘤的变化被联系。 | ZHANG Li-jun SHIN Eun Sim YU Zhong-xing LI Shi-bo | 2007 | Chinese Medical Journal2007，，22： | 2 |
| 19 | Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis显示文摘 | Chang Sik Yu Hae Ran Yun Eung Jin Shin Kang Yong Lee Nam Kyu Kim Seok-Byung Lim Seong Taek Oh Sung-Bum Kang Won Joon Choi Woo Yong Lee | 2013 | The American Journal of Surgery2013，，： | 2 |
| 20 | His-His-Leu,an angiotensinⅠconverting enzyme inhibitory peptide derived from Korean soybean paste,exerts antihypertensive activity in vivo显示文摘 | Shin Z I Yu R Park S A | 2001 | J Agric Food Chem2001，49，6： | 2 |
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