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| 1 | Understanding and managing the morphology of branches incising into sand-clay deposits in the Dutch Rhine Delta显示文摘在在荷兰的西南的部分的 Rhine-Meuse 三角洲,河分支的形态学高度依赖于心土的 erodibility。在 Haringvliet 河口的闭合以后被开始的侵蚀过程由一个水坝分叉(在 1970 ) ,引起了几个连接分支的一个强壮的切口。由于这个区域的地质的进化,心土的岩性学显示出大变化在高度 erodible 沙并且糟糕 erodible 泥炭和泥土层。这研究显示出地质的信息怎么能被用来创造心土的 erodibility 的 3D 地图,并且这个信息怎么能被用来扼要表示在为词法模拟的计算模型的心土。在区域与之间的沙补丁的本地切入糟糕, erodible 床原因深搜索洞,因此在河岸不稳定性(流动幻灯片) 和象丁提,码头,隧道,和管道那样的构造的损坏上增加风险。数学模型的各种各样的类型,从 1D (SOBEK )到 quasi-3D (Delft3D ) 被使用了学习河床和可能的管理选择的未来发展。这些途径的结果证明模型为心土 schematization 要求一条层簿记途径的包括,不一致的沉积部分(沙泥) ,潮汐并且河分泌物边界条件,和能力减小搬运当模特儿。为减少风险的河管理,河床的发展怎么能在大规模和小规模上被探讨,被显示出。例如,沉积喂和床的固定的使用能为大规模管理被建议,当监视时,当对超过的小规模的开发的反应预先规定干预层次,在侵蚀的开始的干预能被建议。 | Kees SLOFF(C.J.) Ary VAN SPIJK Esther STOUTHAMER Arjan SIEBEN | 2013 | International Journal of Sediment Research2013，28，2： | 3 |
| 2 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 3 | A randomized controlled trial of exercise to improve outcomes of acute hospitalization in older adults显示文摘 | Siebens H Aronow H Edwards D | 2000 | J Am Geriatr Soc2000，48，12： | 1 |
| 4 | Se- vere preeclampsiais associated with a positive family history of hypertension and hypercholes- terolemia 显示文摘 | Roes EM Sieben R Raijmakers MT | 2005 | Hypertens Pregnancy2005，24，： | 1 |
| 5 | Characteristics and outcomes of patients with seizures according to the time of onset in relation to stroke显示文摘 | de Reuck J Sieben A van Maele G | 2008 | Eur Neurol2008，59，5： | 1 |
| 6 | Influenza virus binds its host cell using multiple dynamic interactions显示文摘 | Sieben C Kappel C Zhu R | 2012 | Proc Natl Acad Sci U S A2012，109，13： | 1 |
| 7 | Comparison of different particles and methods for magnetic isolation of circulating tumor cells显示文摘 | Sieben S Bergemann C Lubbe A Brockmann B Reschele it D | 2001 | Journal of Magnetism and Magnetic Materials2001，225，： | 1 |
| 8 | Comparison of different particles and methods for magnetic isolation of circulating tumor cells显示文摘 | SIEBEN S BERGEMANN C LUBBE A | 2001 | J Magn Magn Mater2001，225，12： | 1 |
| 9 | Severe preecltampsia is associated with a positive family history of hypertension and hypercholesterolemia 显示文摘 | Roes EM Sieben R Raijmakers MT | 2005 | Hypertens Pregnancy2005，24，： | 1 |
| 10 | Dysphagia: Predicting laryngeal penetration 显示文摘 | Linden P Siebens AA | 1983 | Arch Phys Med Rehabil1983，64，： | 1 |
| 11 | Determination of cellulase activity using hydroxyethylcellulose as substrate显示文摘 | Child JJ Eveleigh DE Sieben AS | 1973 | Canadian Journal of Biochemistry1973，51，1： | 1 |
| 12 | Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of 2-adrenergic re- ceptors 显示文摘 | Sieben A Prenner L Sorkalla T | 2009 | Biochem2009，48，15： | 1 |
| 13 | Delayed -type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones 显示文摘 | Sieben S Kawakubo Y A1Masaoudi T | 2002 | J Allergy Clin Immunol2002，109，6： | 1 |
| 14 | Sevene Preeclampasiais assciated with a positive fatuity history of hypertension and hype- reholesterdemia显示文摘 | Roes EM Sieben R Raijrmrkers MR | 2005 | Hypertens Pregnancy2005，24，3： | 1 |
| 15 | Dysphagia: predicting laryng~ penetration显示文摘 | Linden P Siebens AA | 1983 | Arch Phys Med Rehabil1983，64，： | 1 |
| 16 | Concepts and working instruments for corporate governance显示文摘 | Siebens H | 2002 | Journal of Business Ethics2002，39，： | 1 |
| 17 | Severe preeclampsia is associated with a positive family history of hypertension and hypercho Lesterolemia显示文摘 | Rots EM Sieben R Raijnakers MT | 2005 | Hypertens pregnancy2005，24，3： | 1 |
| 18 | Severe pre- eelampsia is associated with a positive family history of hypertension and hypercholesterolemia显示文摘 | Rose EM Sieben R Raijmakers MT | 2005 | Hypertensive Pregnancy2005，24，3： | 1 |
| 19 | Identification of N - acetyltransferase 2 genotypes by continuous monitoring fluorogenic hybridization probes显示文摘 | Blomeke B Sieben S | 1999 | Anal Biochem1999，275，1： | 1 |
| 20 | A theoretical analysis of discontinuous flow with mobile bed显示文摘 | Sieben J | 1999 | J Hydraul Res1999，37，2： | 1 |
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