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| 1 | MRI-determined fat content of human liver,pancreas and kidney显示文摘AIM:To assess and correlate the lipid content of various organs in obese subjects and in persons with a normal body weight.METHODS:Magnetic resonance spectroscopy and a previously validated gradient echo magnetic resonance imaging method with Dixon's two point technique were used in this study to quantify fat in liver,pancreas as well as kidney.RESULTS:In 36 volunteers with body mass index(BMI) ranging from 20.0 to 42.9 kg/m2,the median fat content of liver,pancreas and kidney was 2.3%(interquartile range:0.2%-7.8%),2.7%(1.0%-6.5%) and 0.7%(0.1%-1.4%),respectively.BMI and subcutaneous fat correlated significantly with liver and pancreas fat content.We show for the first time the significant correlation of liver and pancreas fat content in healthy controls(r = 0.43,P < 0.01).These observations are related to body weight as measured by BMI and the amount of subcutaneous fat.Kidney fat content is very low and correlates with none of the other fat depots.CONCLUSION:Renal lipid accumulation,unlike the coupled accumulations of fat in liver and pancreas,is not observed in obese subjects.Unlike suggestions made in previous studies,renal lipid accumulation appears not to be involved in the pathogenesis of renal disease in humans. | Paul E Sijens Mireille A Edens Stephan JL Bakker Ronald P Stolk | 2010 | World Journal of Gastroenterology2010，16，16： | 14 |
| 2 | On the role of RNA amplification in dsRNA-triggered gene silencing 显示文摘 | Sijen T Fleenor J Simmer F | 2001 | Cell2001，107，4： | 1 |
| 3 | Hybridoma antibodies to poliovims N and H antigen显示文摘 | Brioen P Sijens RJ Vrijsen R | 1982 | Arch Virol1982，74，4： | 1 |
| 4 | RNA-mediatedvirus resitance, role of repeated transgenes and deline- ation of targeted regions 显示文摘 | Sijen T Wellink J Hiriart J B | 1996 | Plant Cell1996，8，： | 1 |
| 5 | On the role of RNA amplification in dsRNA-triggered gene silencing显示文摘 | Sijen T Fleenor J Simmer F | 2001 | Cell2001，107，4： | 1 |
| 6 | Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi显示文摘 | Sijen Plasterk R H | 2003 | Nature2003，426，： | 1 |
| 7 | Transposon sliencing in the Caenorhabditis elegans germ line by natural RNAi显示文摘 | SIJEN PLASTERK R H | 2003 | Nature 4262003，，： | 1 |
| 8 | Adenosine trlphosphate infusion increases liver energy status in advanced lung cancerpafients: an in vivo ^31P-magnetic resonance spectroscopy study显示文摘 | Leij H Agteresch HJ Sijens PE | 2002 | Hepatology2002，28，： | 1 |
| 9 | 1H chemical shift imaging charac- terization of human brain tumor and edema 显示文摘 | Sijens PE Oudkerk M | 2002 | Eur Radiol2002，12，： | 1 |
| 10 | On the role of RNA amplification in dsRNA-triggered gene silencing显示文摘 | Sijen T Fleenor J Simmer F | 2001 | Cell2001，107，4： | 1 |
| 11 | MR spectroscopy of the brain in Leigh syndrome显示文摘 | Sijens PE Smit GP R? diger LA | 2008 | Brain Dev2008，30，： | 1 |
| 12 | On the role of RNA amplification in dsRNA-triggered gene silencing 显示文摘 | Sijen T Fleenor J Simmer F | 2001 | Cell2001，107，4： | 1 |
| 13 | 1H MR spectroscopy in patients with metastatic brain tumors:a multicenter study显示文摘 | Sijens PE Knopp MV Brunetti A | 1995 | Magn Reson Med1995，33，6： | 1 |
| 14 | On the Role of RNA Amplification in dsRNA-Triggered C,ene Silencing显示文摘 | Sijen T Fleenor J Simmer F | 2001 | Cell2001，107，4： | 1 |
| 15 | Secondary siRNAs Result from Unprimed RNA Synthesis and Form a Distinct Class显示文摘 | Sijen T Steiner F A Thijssen K L | 2007 | Science2007，315，5809： | 1 |
| 16 | Liver magnetic resonance imaging: State of the art显示文摘Magnetic resonance imaging (MRI) has now been used for about three decades to characterize the human liver in a non-invasive way, that is without the need of using ionizing radiation or removing tissue samples. During the past few years, technical progress has been considerable and novel applications of MRI have been implemented in the clinic. The beginning of a new decade offers an excellent opportunity for having fi ve experts to present their view on the current status of MRI (and magnetic resonance spectroscopy) in the study of perfusion, fat and iron contents, diffusion and the metabolism of diffuse liver diseases. This topic highlight series thus provides an update of current knowledge in the fi eld of liver MRI. | Paul E Sijens | 2010 | World Journal of Gastroenterology2010，16，13： | 1 |
| 17 | On the role of RNA amplification in dsRNA-triggered gene silencing 显示文摘 | Sijen T Fleenor J Simmer F | 2001 | Cell2001，107，4： | 1 |
| 18 | 1H Chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men显示文摘 | Sijens PE Oudkerk M De Leeuw FE | 1999 | Magn Reson Med1999，42，： | 1 |
| 19 | 1H MR spectroscopy detection of lipids and lactata in metastatic brain tumors显示文摘 | Levendag PC Vecht CJ | 1996 | NMR Biomed1996，9，2： | 1 |
| 20 | ^1HMR spectroscopy detection of lipids and lactate in metastatic brain tumors显示文摘 | Sijens PE Leverdag PC Vecht CJ | 1996 | NMR Biomed1996，9，2： | 1 |
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