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| 1 | Active power regulation of wind power systems through demand response显示文摘With the specific characteristics of low-carbon intensity and economy,wind power has been widely promoted around the world.Due to the variable and intermittent nature of wind power production,the system has to frequently redispatch generators in order to ensure the effective use of wind power whilst maintaining system security.In this way,traditional generation costs are increased and the social benefit of wind power decreases indirectly.In this paper,a new regulation strategy based on power flow tracing was proposed,taking advantage of a comfort-constrained demand response strategy to follow the fluctuations of wind farm output,with the remaining imbalance of active power compensated by traditional generators.Examples showed that compared with conventional regulation,demand response could reduce the gross operating costs of the system,and the rapid response could help maintaining system stability in case of contingency.The strategy in this paper also applies to other large-scale integration problems associated with renewable energy resources which display short-term production variability. | MIAO WeiWei JIA HongJie WANG Dan PARKINSON Simon CRAWFORD Curran DJILALI Ned | 2012 | Science China(Technological Sciences)2012，55，6： | 24 |
| 2 | Analysis on Factors Related to Rabies Epidemic in China from 2007-2011显示文摘To analyze features of the rabies epidemic in China between 2007 and 2011, identify factors influencing the epidemic and to provide a scientific basis for further control and prevention of rabies, Descriptive epidemiological methods and statistical analysis was used on data collected from the National Disease Reporting Information System between 2007 to 2011 and the National Active Surveillance System between 2007 and 2010. Our analysis shows that while the number of human rabies cases decreased year by year, the number of districts reporting cases did not show significant change. The situations in Guangdong, Guangxi, Guizhou and Hunan provinces clearly improved over the period but they remain provinces with high-incidence, and consequently influence the epidemic situation of surrounding provinces and possibly the whole country. Summer and autumn were high-incidence seasons. Farmers, students and pre-school children represent the high-risk populations, and rates of cases in farmers increased, those for students decreased, and pre-school children remained unchanged. Provinces with active surveillance programs reported a total of 2346 individual cases, of which 88.53% were associated with canines. Postexposure prophylaxis (PEP) of rabies cases was not significantly improved, whereas PEP in post-exposure population was good. In rural regions of China, canine density was reduced somewhat, and the immunization rate increased slightly. Finally we show that while the epidemic decreased 2007 to 2011 in China, cases continued to be diffused in certain regions. Lack of standardization of PEP on rabies cases was the main reason of morbidity. The high density and low immunization of dog in rural areas and the defective situation of PEP are still continuous occurrences in China and remain a cause for concern. | Cui-ping Yin Hang Zhou Hui Wu Xiao-yan Tao Simon Rayner Shu-mei Wang Qing Tang Guo-dong Liang | 2012 | Virologica Sinica2012，27，2： | 22 |
| 3 | Potentially dangerous glacial lakes across the Tibetan Plateau revealed using a large-scale automated assessment approach显示文摘Glacial lake outburst floods(GLOFs) are a major concern in the Himalaya and on the Tibetan Plateau(TP),where several disasters occurring over the past century have caused significant loss of life and damage to infrastructure. This study responds directly to the needs of local authorities to provide guidance on the most dangerous glacial lakes across TP where local monitoring and other risk reduction strategies can subsequently be targeted. Specifically, the study aims to establish a first comprehensive prioritisation ranking of lake danger for TP, considering both the likelihood and possible magnitude of any outburst event(hazard), and the exposure of downstream communities. A composite inventory of 1,291 glacial lakes(>0.1 km^2) was derived from recent remote sensing studies, and a fully automated and object assessment scheme was implemented using customised GIS tools. Based on four core determinates of GLOF hazard(lake size, watershed area, topographic potential for ice/rock avalanching, and dam steepness), the scheme accurately distinguishes the high to very high hazard level of 19 out of 20 lakes that have previously generated GLOFs. Notably, 16% of all glacial lakes threaten human settlements, with a hotspot of GLOF danger identified in the central Himalayan counties of Jilong, Nyalam, and Dingri, where the potential trans-boundary threat to communities located downstream in Nepal is also recognised. The results provide an important and object scientific basis for decision-making, and the methodological approach is ideally suited for replication across other mountainous regions where such first-order studies are lacking. | Simon Keith Allen Guoqing Zhang Weicai Wang TANDong Yao Tobias Bolch | 2019 | Science Bulletin2019，64，7： | 20 |
| 4 | Synergistic Effects of Chuanxiong-Chishao Herb-Pair on Promoting Angiogenesis at Network Pharmacological and Pharmacodynamic Levels显示文摘Objective: To investigate the synergistic effects of Chuanxiong-Chishao herb-pair(CCHP) on promoting angiogenesis in silico and in vivo. Methods: The mechanisms of action of an herb-pair, ChuanxiongChishao, were investigated using the network pharmacological and pharmacodynamic strategies involving computational drug target prediction and network analysis, and experimental validation. A set of network pharmacology methods were created to study the herbs in the context of targets and diseases networks, including prediction of target profiles and pharmacological actions of main active compounds in Chuanxiong and Chishao. Furthermore, the therapeutic effects and putative molecular mechanisms of Chuanxiong-Chishao actions were experimentally validated in a chemical-induced vascular insufficiency model of transgenic zebrafish in vivo. The m RNA expression of the predicted targets were further analyzed by real-time polymerase chain reaction(RT-PCR). Results: The computational prediction results found that the compounds in Chuanxiong have antithrombotic, antihypertensive, antiarrhythmic, and antiatherosclerotic activities, which were closely related to protecting against hypoxic-ischemic encephalopathy, ischemic stroke, myocardial infarction and heart failure. In addition, compounds in Chishao were found to participate in anti-inflammatory effect and analgesics. Particularly, estrogen receptor α(ESRα) and hypoxia-inducible factor 1-α(HIF-1α) were the most important potential protein targets in the predicted results. In vivo experimental validation showed that post-treatment of tetramethylpyrazine hydrochloride(TMP·HCl) and paeoniflorin(PF) promoted the regeneration of new blood vessels in zebrafish involving up-regulating ESRα m RNA expression. Co-treatment of TMP·HCl and PF could enhance the vessel sprouting in chemical-induced vascular insufficiency zebrafish at the optimal compatibility proportion of PF 10 μmol/L with TMP·HCl 1 μmol/L. Conclusions: The network pharmacological strategies combining drug target prediction and network analysis identified some putative targets of CCHP. Moreover, the transgenic zebrafish experiments demonstrated that the Chuanxiong-Chishao combination synergistically promoted angiogenic activity, probably involving ESRα signaling pathway. | WANG Yan GUO Gang YANG Bin-rui XIN Qi-qi LIAO Qi-wen LEE Simon Ming-Yuen HU Yuan-jia CHEN Ke-ji CONG Wei-hong | 2017 | Chinese Journal of Integrative Medicine2017，23，9： | 19 |
| 5 | Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG显示文摘Two recently engineered SpCas9 variants, namely xCas9 and Cas9-NG, show promising potential in improving targeting specificity and broadening the targeting range. In this study, we evaluated these Cas9 variants in the model and crop plant, rice. We first tested xCas9-3.7, the most effective xCas9 variant in mammalian cells, for targeted mutagenesis at 16 possible NGN PAM (protospacer adjacent motif) combinations in duplicates. xCas9 exhibited nearly equivalent editing efficiency to wild-type Cas9 (Cas9-WT) at most canonical NGG PAM sites tested, whereas it showed limited activity at non-canonical NGH (H = A, C, T) PAM sites. High editing efficiency of xCas9 at NGG PAMs was further demonstrated with C to T base editing by both rAPOBECI and PmCDAI cytidine deaminases. With mismatched sgRNAs, we found that xCas9 had improved targeting specificity over the Cas9-WT. Furthermore, we tested two Cas9-NG variants, Cas9-NGv1 and Cas9-NG, for targeting NGN PAMs. Both Cas9-NG variants showed higher editing efficiency at most non-canonical NG PAM sites tested, and enabled much more efficient editing than xCas9 at AT-rich PAM sites such as GAT, GAA, and CAA. Nevertheless, we found that Cas9-NG variants showed significant reduced activity at the canonical NGG PAM sites. In stable transgenic rice lines, we demonstrated that Cas9-NG had much higher editing efficiency than Cas9-NGv1 and xCas9 at NG PAM sites. To expand the base-editing scope, we developed an efficient C to T base-editing system by making fusion of Cas9-NG nickase (D10A version), PmCDAI, and UGI. Taken together, our work benchmarked xCas9 as a high-fidelity nuclease for targeting canonical NGG PAMs and Cas9-NG as a preferred variant for targeting relaxed PAMs for plant genome editing. | Zhaohui Zhong Simon Sretenovic Qiurong Ren Lijia Yang Yu Bao Caiyan Qi Mingzhu Yuan Yao He Shishi Liu Xiaopei Liu Jiaheng Wang Lan Huang Yan Wang Dibin Baby David Wang Tao Zhang Yiping Qi Yong Zhang | 2019 | Molecular Plant2019，12，7： | 13 |
| 6 | Essential oil of Curcuma wenyujin induces apoptosis in human hepatoma cells显示文摘AIM: To investigate the effects of the essential oil of Curcuma wenyujin (CWO) on growth inhibition and on the induction of apoptosis in human HepG2 cancer cells. METHODS: The cytotoxic effect of drugs on HepG2 cells was measured by 3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetra-zolium bromide (MTT) assay. DNA fragmentation was visualized by agarose gel electrophoresis. Cell cycle and mitochondrial transmembrane potential (△Ψm) were determined by flow cytometry (FCM). Cytochrome C immunostaining was evaluated by fluorescence microscopy. Caspase-3 enzymatic activity was assayed by the cleavage of Ac-DEVD-R110. Cleaved PARP and active caspase-3 protein levels were measured by FCM using BD? CBA Human Apoptosis Kit. RESULTS: Treatment with CWO inhibited the growth of HepG2 cells in a dose-dependent manner, and the IC50 of CWO was approximately 70 μg/mL. CWO was found to inhibit the growth of HepG2 cells by inducing a cell cycle arrest at S/G2. DNA fragmentation was evidentlyobserved at 70 μg/mL after 72 h of treatment. During the process, cytosolic HepG2 cytochrome C staining showed a markedly stronger green fluorescence than in control cells in a dose-dependent fashion, and CWO also caused mitochondrial transmembrane depolarization. Furthermore, the results clearly demonstrated that both, activity of caspase-3 enzyme and protein levels of cleaved PARP, significantly increased in a dose- dependent manner after treatment with CWO. CONCLUSION: CWO exhibits an antiproliferative effect in HepG2 cells by inducing apoptosis. This growth inhibition is associated with cell cycle arrest, cytochrome C translocation, caspase 3 activation, Poly- ADP-ribose polymerase (PARP) degradation, and loss of mitochondrial membrane potential. This process involves a mitochondria-caspase dependent apoptosis pathway. As apoptosis is an important anti-cancer therapeutic target, these results suggest a potential of CWO as a chemotherapeutic agent. | YU Xiao Feng-Qing Yang Shao-Ping Li Guang Hu Simon Ming-Yuen Lee Yi-Tao Wang | 2008 | World Journal of Gastroenterology2008，14，27： | 13 |
| 7 | 基于体波有限频层析成像的青藏高原南部和中部下方印度大陆岩石层俯冲和撕裂的三维图像显示文摘使用TIBET-31N无源地震台阵以及以前临时地震台阵记录到的远震体波数据进行了有限频层析成像反演,对青藏高原南部及中部的三维速度结构成像。在喜马拉雅和拉萨地块下方存在向北倾角40°的高速体。我们把这些高速异常区域解释为俯冲的印度大陆岩石层(ICL)。印度大陆岩石层似乎在青藏高原中部比东部向北延伸更多——沿85°E在31°N到达350km深处,而沿91°E则是在30°N到达350km深度。P波和S波低速异常区在当惹雍错裂谷、亚东—谷露裂谷和错那裂谷下方从下地壳延伸至≥180km深度,这表明青藏高原南部的裂谷可能包含了整个岩石层的变形。当惹雍错裂谷下方的异常区向下延伸到约180km,而亚东—谷露裂谷西部和错那裂谷东部的异常延伸到了超过300km的深度。亚东—谷露裂谷西部的低速区上地幔延伸至最北,并且似乎与青藏高原中部下方广阔的上地幔低速区相连。于是,北向俯冲的印度板块沿着南北走向的裂缝撕裂。这些裂缝允许或者导致的软流层上涌同青藏高原北部上地幔相类似。 | Xiaofeng Liang Yun Chen Xiaobo Tian Yongshun John Chen James Ni Andrea Gallegos Simon L.Klemperer Minling Wang Tao Xu Changqing Sun Shaokun Si Haiqiang Lan Jiwen Teng 左思成 | 2016 | 世界地震译丛2016，47，6： | 8 |
| 8 | Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress显示文摘AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity. | Yue Zong Chen-Song Zhang Mengqi Li Wen Wang Zhichao Wang Simon A. Hawley Teng Ma Jin-Wei Feng Xiao Tian Qu Qi Yu-Qing Wu Cixiong Zhang Zhiyun Ye Shu-Yong Lin Hai-Long Piao D. Grahame Hardie Sheng-Cai Lin | 2019 | Cell Research2019，29，6： | 8 |
| 9 | Inhibition of Navl.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions显示文摘目的: 甲基 eugenol 是从中国植物 Asari 根值 et 根茎提取的一个主要活跃部件,它被用来治疗牙疼和其它疼痛。以前的在里面 vivo 研究证明了甲基 eugenol 有麻药和 antinociceptive 效果。这研究的目的是决定在神经系统混乱上位于它的效果下面的可能的机制。 | Ze-Jun WANG Boris TABAKOFF Simon R LEVINSON Thomas HEINBOCKEL | 2015 | Acta Pharmacologica Sinica2015，36，7： | 7 |
| 10 | Biology,invasion and management of the agricultural invader:Fall armyworm,Spodoptera frugiperda(Lepidoptera:Noctuidae)显示文摘The fall armyworm(FAW),Spodoptera frugiperda(J.E.Smith),is native to the Americas.It has rapidly invaded 47 African countries and 18 Asian countries since the first detection of invasion into Nigeria and Ghana in 2016.It is regarded as a super pest based on its host range(at least 353 host plants),its inherent ability to survive in a wide range of habitats,its strong migration ability,high fecundity,rapid development of resistance to insecticides/viruses and its gluttonous characteristics.The inherently superior biological characteristics of FAW contribute to its invasiveness.Integrated pest management(IPM)of FAW has relied on multiple applications of monitoring and scouting,agricultural control,chemical pesticides,viral insecticides,sex attractants,bio-control agents(parasitoids,predators and entomopathogens)and botanicals.Knowledge gaps remain to be filled to:(1)understand the invasive mechanisms of S.frugiperda;(2)understand how to prevent its further spread and(3)provide better management strategies.This review summarizes the biological characters of FAW,their association with its invasiveness and IPM strategies,which may provide further insights for future management. | Jing WAN HUANG Cong LI Chang-you ZHOU Hong-xu REN Yong-lin LI Zai-yuan XING Long-sheng ZHANG Bin QIAO Xi LIU Bo LIU Cong-hui XI Yu LIU Wan-xue WANG Wen-kai QIAN Wan-qiang Simon MCKIRDY WAN Fang-hao | 2021 | Journal of Integrative Agriculture2021，20，3： | 7 |
| 11 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 12 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 13 | Capecitabine with radiation is an effective adjuvant therapy in gastric cancers显示文摘AIM:To analyze the outcome of patients who received concurrent capecitabine(Xeloda) and radiation(XRT) compared to the established concurrent 5-fluorouracil(5-FU) with radiation(5FU-RT) and fluoropyrimidine-based chemotherapy alone as adjuvant treatment in gastric cancers.METHODS:All patients with gastric cancers who received adjuvant treatment at the National Cancer Centre Singapore between 1996 and 2006 were reviewed.Treatment outcomes of patients who received XRT were compared with those who had 5FU-RT or chemotherapy alone as adjuvant therapy for gastric cancers.RESULTS:A total of 108 patients were reviewed.Median age at diagnosis was 60.The majority of the patients(64.8%) had advanced stage Ⅲ and Ⅳ disease(with no distant metastasis).All except 4 patients had D2 gastrectomy.Twenty one patients(19.4%) had positive surgical resection margins.Thirty three patients received XRT compared with 52 who had 5FU-RT and 23 who received chemotherapy alone.For the patients in the chemotherapy-only group,all had fluoropyrimidine-based therapy,with added cisplatin in 7 patients and epirubicin in 2 patients.Median recurrence-free survival was longer for the XRT group(52 mo) compared to the 5FU-RT(35 mo) and chemotherapy-only groups(25 mo)(P=0.48).The patients in the XRT group achieved similar median overall survival(53 mo) as the 5FU-RT(54 mo) and the chemotherapy-only groups(44 mo)(P=0.5).CONCLUSION:Capecitabine with concurrent radiation was as effective as concurrent 5FU with radiation or fluoropyrimidine-based chemotherapy alone when used as adjuvant treatment in patients with gastric cancers. | Chee Kian Tham Su Pin Choo Donald Yew Hee Poon Han Chong Toh Simon Yew Kuang Ong Sze Huey Tan Michael Lian Chek Wang Kian Fong Foo | 2010 | World Journal of Gastroenterology2010，16，29： | 6 |
| 14 | Inferring the Tree of Life of the order Cypriniformes, the earth's most diverse clade of freshwater fishes: Implications of varied taxon and character sampling显示文摘The phylogenetic relationships of species are fundamental to any biological investigation, including all evolutionary studies. Accurate inferences of sister group relationships provide the researcher with an historical framework within which the attributes or geographic origin of species (or supraspecific groups) evolved. Taken out of this phylogenetic context, interpretations of evolutionary processes or origins, geographic distributions, or speciation rates and mechanisms, are subject to nothing less than a biological experiment without controls. Cypriniformes is the most diverse clade of freshwater fishes with estimates of diversity of nearly 3,500 species. These fishes display an amazing array of morphological, ecological, behavioral, and geographic diversity and offer a tremendous opportunity to enhance our understanding of the biotic and abiotic factors associated with diversification and adaptation to environments. Given the nearly global distribution of these fishes, they serve as an important model group for a plethora of biological investigations, including indicator species for future cli-matic changes. The occurrence of the zebrafish, Danio rerio, in this order makes this clade a critical component in understanding and predicting the relationship between mutagenesis and phenotypic expressions in vertebrates, including humans. With the tremendous diversity in Cypriniformes, our understanding of their phylogenetic relationships has not proceeded at an acceptable rate, despite a plethora of morphological and more recent mo-lecular studies. Most studies are pre-Hennigian in origin or include relatively small numbers of taxa. Given that analyses of small numbers of taxa for molecular characters can be compromised by peculiarities of long-branch attraction and nodal-density effect, it is critical that significant progress in our understanding of the relationships of these important fishes occurs with increasing sampling of species to mitigate these potential problems. The recent Cypriniformes Tree of Life initiative is an effort to achieve this goal with morphological and molecular (mitochondrial and nuclear) data. In this early synthesis of our understanding of the phylogenetic relationships of these fishes, all types of data have contributed historically to improving our understanding, but not all analyses are complementary in taxon sampling, thus precluding direct understanding of the impact of taxon sampling on achieving accurate phylogenetic inferences. However, recent molecular studies do provide some insight and in some instances taxon sampling can be implicated as a variable that can influence sister group relationships. Other instances may also exist but without inclusion of more taxa for both mitochondrial and nuclear genes, one cannot distinguish between inferences being dictated by taxon sampling or the origins of the molecular data. | Richard L. MAYDEN Kevin L. TANG Robert M. WOOD Wei-Jen CHEN Mary K. AGNEW Kevin W. CONWAY Lei YANG Andrew M. SIMONS Henry L. BART Phillip M. HARRIS Junbing LI Xuzhen WANG Kenji SAITOH Shunping HE Huanzhang LIU Yiyu CHEN Mutstmi NISHIDA Masaki MIYA | 2008 | 植物分类学报2008，46，3： | 5 |
| 15 | Inactivation of Mitochondrial Complex Ⅰ Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function显示文摘At12Cys-1 (At5g64400 ) 和 At12Cys-2 (At5g09570 ) 是二密切相关的 isogenes 编码小、成双的半胱氨酸蛋白质,典型地在线粒体定位了。At12Cys-2 抄本与破坏 mitochondrial 蛋白质,而是 At12Cys 的增加在许多异种被导致蛋白质仅仅与减少的 mitochondrial 在异种被检测复杂我丰富。在缺乏 mitochondrial 建筑群的异种的 At12Cys 蛋白质感应我被位于线粒体,叶绿体,和 cytosol 的 At12Cys 蛋白质伴随。生物化学的分析揭示了那甚至单个的基因删除,即, At12cys-1 或 At12cys-2,在 mitochondrial 和叶绿体功能上有效果。然而,仅仅加倍异种,即, At12cys-1 : At12cys-2,影响许多蛋白质和 mRNA 抄本编码翻译延伸因素以及 rRNA 丰富。蓝本国的页证明 At12Cys 与 mitochondrial supercomplex 共同移居我 + III。同样, At12cys-1 和 At12cys-2 基因的删除,然而并非单个基因删除,导致提高的忍耐到干旱和轻应力和增加的抗氧化剂能力。正式就职和在在建筑群的减小之上的 At12Cys 的多重本地化我丰富提供机制明确地表明 mitochondrial 机能障碍到 cytosol 然后在以外到在房间的另外的细胞器。 | Yan Wang Wenhui Lyu Oliver Berkowitz Jordan D. Radomiljac Simon R. Law Monika W. Murcha Chris Carrie Pedro F. Teixeira Beata Kmiec Owen Duncan Olivier Van Aken Reena Narsai Elzbieta Glaser Shaobai Huang Ute Roessner A. Harvey Millar James Whelan | 2016 | Molecular Plant2016，9，5： | 5 |
| 16 | Predicting the potential geographic distribution of Bactrocera bryoniae and Bactrocera neohumeralis(Diptera: Tephritidae) in China using MaxEnt ecological niche modeling显示文摘Bactrocera bryoniae and Bactrocera neohumeralis are highly destructive and major biosecurity/quarantine pests of fruit and vegetable in the tropical and subtropical regions in the South Pacific and Australia.Although these pests have not established in China,precautions must be taken due to their highly destructive nature.Thus,we predicted the potential geographic distribution of B.bryoniae and B.neohumeralis across the world and in particular China by ecological niche modeling of the Maximum Entropy(Max Ent)model with the occurrence records of these two species.Bactrocera bryoniae and B.neohumeralis exhibit similar potential geographic distribution ranges across the world and in China,and each species was predicted to be able to distribute to over 20%of the globe.Globally,the potential geographic distribution ranges for these two fruit fly species included southern Asia,the central and the southeast coast of Africa,southern North America,northern and central South America,and Australia.While within China,most of the southern Yangtze River area was found suitable for these species.Notably,southern China was considered to have the highest risk of B.bryoniae and B.neohumeralis invasions.Our study identifies the regions at high risk for potential establishment of B.bryoniae and B.neohumeralis in the world and in particular China,and informs the development of inspection and biosecurity/quarantine measures to prevent and control their invasions. | Jing Wan QI Guo-jun MA Jun Yonglin REN WANG Rui Simon MCKIRDY | 2020 | Journal of Integrative Agriculture2020，19，8： | 5 |
| 17 | Paeoniflorin Promotes Angiogenesis in A Vascular Insufficiency Model of Zebrafish in vivo and in Human Umbilical Vein Endothelial Cells in vitro显示文摘Objective: To investigate the pro-angiogenic effects of paeoniflorin(PF) in a vascular insufficiency model of zebrafish and in human umbilical vein endothelial cells(HUVECs). Methods: In vivo, the pro-angiogenic effects of PF were tested in a vascular insufficiency model in the Tg(fli-1:EGFP)y1 transgenic zebrafish. The 24 h post fertilization(hpf) embryos were pretreated with vascular endothelial growth factor(VEGF) receptor tyrosine kinase inhibitor Ⅱ(VRI) for 3 h to establish the vascular insufficiency model and then post-treated with PF for 24 h. The formation of intersegmental vessels(ISVs) was observed with a fluorescence microscope. The m RNA expression of fms-like tyrosine kinase-1(flt-1), kinase insert domain receptor(kdr), kinase insert domain receptor like(kdrl) and von Willebrand factor(v WF) were analyzed by real-time polymerase chain reaction(PCR). In vitro, the pro-angiogenic effects of PF were observed in HUVECs in which cell proliferation, migration and tube formation were assessed. Results: PF(6.25–100 μmol/L) could rescue VRI-induced blood vessel loss in zebrafish and PF(25–100 μmol/L), thereby restoring the m RNA expressions of flt-1, kdr, kdrl and v WF, which were down-regulated by VRI treatment. In addition, PF(0.001–0.03 μmol/L) could promote the proliferation of HUVECs while PF stimulated HUVECs migration at 1.0–10 μmol/L and tube formation at 0.3 μmol/L. Conclusion: PF could promote angiogenesis in a vascular insufficiency model of zebrafish in vivo and in HUVECs in vitro. | XIN Qi-qi YANG Bin-rui ZHOU He-feng WANG Yan YI Bo-wen CONG Wei-hong LEE Simon Ming-Yuen CHEN Ke-ji | 2018 | Chinese Journal of Integrative Medicine2018，24，7： | 5 |
| 18 | Novel Evidence Suggests Hepatitis B Virus Surface Proteins Participate in Regulation of HBV Genome Replication显示文摘Naturally occurring mutations in surface proteins of Hepatitis B virus(HBV) usually result in altered hepatitis B surface antigen(HBsAg) secretion efficiency.In the present study,we reported two conserved residues,M75 and M103 with respect to HBsAg,mutations of which not only attenuated HBsAg secretion(M75 only),but also suppressed HBV genome replication without compromising the overlapping p-gene product.We also found M75 and M103 can initiate truncated surface protein(TSPs) synthesis upon over-expression of full-length surface proteins,which may possibly contribute to HBV genome replication.However,attempts to rescue replicationdefective HBV mutant by co-expression of TSPs initiated from M75 or M103 were unsuccessful,which indicated surface proteins rather than the putative TSPs were involved in regulation of HBV genome replication. | Jian Qiu Bo Qin Simon Rayner Chun-chen Wu Rong-juan Pei Song Xu Yun Wang Xin-wen Chen | 2011 | Virologica Sinica2011，26，2： | 4 |
| 19 | Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway显示文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones. | Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang | 2020 | World Journal of Gastroenterology2020，26，47： | 3 |
| 20 | A Software-in-the-Loop Implementation of Adaptive Formation Control for Fixed-Wing UAVs显示文摘This paper discusses the design and software-in-theloop implementation of adaptive formation controllers for fixedwing unmanned aerial vehicles(UAVs) with parametric uncertainty in their structure, namely uncertain mass and inertia. In fact, when aiming at autonomous flight, such parameters cannot assumed to be known as they might vary during the mission(e.g.depending on the payload). Modeling and autopilot design for such autonomous fixed-wing UAVs are presented. The modeling is implemented in Matlab, while the autopilot is based on ArduPilot, a popular open-source autopilot suite. Specifically, the ArduP ilot functionalities are emulated in Matlab according to the Ardupilot documentation and code, which allows us to perform software-in-the-loop simulations of teams of UAVs embedded with actual autopilot protocols. An overview of realtime path planning, trajectory tracking and formation control resulting from the proposed platform is given. The software-inthe-loop simulations show the capability of achieving different UAV formations while handling uncertain mass and inertia. | Jun Yang Ximan Wang Simone Baldi Satish Singh Stefano Fari | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，5： | 3 |
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