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| 1 | Anti-tumor activity of thalidomide in refractory multiple myeloma显示文摘 | Singhal S Mehta J Desikan R | | 0，，： | 8 |
| 2 | Nrf2 is required for normal postnatal bone acquisition in mice显示文摘A large body of literature suggests that bone metabolism is susceptible to the ill effects of reactive species that accumulate in the body and cause cellular dysfunction. One of the body's front lines in defense against such damage is the transcription factor, Nrf2. This transcription factor regulates a plethora of antioxidant and cellular defense pathways to protect cells from such damage. Despite the breadth of knowledge of both the function of Nrf2 and the effects of reactive species in bone metabolism, the direct role of Nrf2 in skeletal biology has yet to be thoroughly examined. Thus, in the current study, we have examined the role of Nrf2 in postnatal bone metabolism in mice. Mice lacking Nrf2(Nrf22/2) exhibited a marked deficit in postnatal bone acquisition,which was most severe at 3 weeks of age when osteoblast numbers were 12-fold less than observed in control animals. While primary osteoblasts from Nrf22/2mice functioned normally in vitro, the colony forming capacity of bone marrow stromal cells(BMSCs) from these mice was significantly reduced compared to controls.This defect could be rescued through treatment with the radical scavenger N-acetyl cysteine(NAC), suggesting that increased reactive species stress might impair early osteoblastogenesis in BMSCs and lead to the failure of bone acquisition observed in Nrf22/2animals. Taken together, these studies suggest Nrf2 represents a key pathway in regulating bone metabolism, which may provide future therapeutic targets to treat osteoporosis. | Jung-Hyun Kim Vandana Singhal Shyam Biswal Rajesh K Thimmulappa Douglas J Di Girolamo | 2014 | Bone Research2014，2，4： | 3 |
| 3 | Antitumor activity of thalidomide in refractory multiple myeloma显示文摘 | Singhal S Mehta J Desikan R | 1999 | N Engl J Med1999，341，21： | 1 |
| 4 | Marked anti-tumor effect from anti-angiogenesis therapy with thalidomide in high risk refractory multiple myeloma显示文摘 | Mehta J Eddiemon P | 1998 | Blood1998，92，1： | 1 |
| 5 | Antitumor activity of thalidomide in refractorymultiple myeloma显示文摘 | SINGHAL S MEHTA J DESIKAN R | 1999 | N Engl J Med1999，34，18： | 1 |
| 6 | Antitumor activity of thalidomide in refractory multiple myeloma 显示文摘 | SINGHAL S MEHTA J DESIKAN R | 1999 | N Engl J Med1999，341，： | 1 |
| 7 | Antitumor activity of thalido-mide in refractory multiple myeloma显示文摘 | Singhal S Mehta J Desikan R | 1999 | N Engl Med1999，341，21： | 1 |
| 8 | Thalidomidein cancer显示文摘 | Singhal S Metha J | 2002 | Biomed Pharmacother2002，56，1： | 1 |
| 9 | The clinical signifcance of serum transferring receptor levels in sickle cell disease显示文摘 | Singhal A Cook J D Sikne B S | 1993 | Br J Haematol1993，84，： | 1 |
| 10 | Interpolation using fast Fourier transform显示文摘 | SINGHAL K VLACH J | 1972 | Proceedings of the IEEE1972，，： | 1 |
| 11 | Convexity Subarachnoid Hemorrhage with Pi B Positive Pet Scans:Clinical Features and Prognosis显示文摘 | Ly J V Singhal S Rowe C C | 2014 | J Neuroimaging2014，，3： | 1 |
| 12 | Thalidomidein cancer 显示文摘 | Singhal S Metha J | 2002 | Biomed Pharmacother2002，56，1： | 1 |
| 13 | Antitumor activity of thalidomide in refractory multiple myelomal显示文摘 | Singhal S Mehta J Desikan R | 1999 | New Eengl J Med1999，341，： | 1 |
| 14 | Antitumor activity of thalidomide in refractory multiple myeloma显示文摘 | Singhal S Mehta J Desikan R | 1999 | N Engl J Med1999，341，21： | 1 |
| 15 | FTIR Spectroscopy, SAXS and Electrical Conductivity Studies of the Hydrolysis and Condensation of Zirconium and Titanium Alkoxides 显示文摘 | Harris M T Singhal A Look J L | 1997 | Journal of Sol-Gel Science and Technology1997，8，123： | 1 |
| 16 | A Bayesian network-based framework for semantic image understanding显示文摘 | Luo J Savakis A E Singhal A | 2005 | Pattern Rec- ognition2005，38，6： | 1 |
| 17 | Antitumor activity of thalidomide in refractory multiple myeloma显示文摘 | Singhal S Mehta J Desikan R | | 0，，21： | 1 |
| 18 | Breastfeeding,early growth and later obesity显示文摘 | Singhal A Lanigan J | | 0，，1： | 1 |
| 19 | Ultra low density and highly crosslinked biocompatible shape memory polyurethane foams显示文摘 | Singhal P Rodriguez J N Small W | 2012 | Journal of Polymer Science Part B: Polymer Physics2012，50，10： | 1 |
| 20 | Bone marrow transplantation from partially HLA-mismatched family donors for acute leukemia;ingle-center experience of 201 patients显示文摘 | Mehta J Singhal S Gee AP | 2004 | Bone Marrow Transplantation2004，33，4： | 1 |
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