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| 1 | Fueling the engine and releasing the break: combinational therapy of cancer vaccines and immune checkpoint inhibitors显示文摘Immune checkpoint inhibitors are increasingly drawing much attention in the therapeutic development for cancer treatment. However, many cancer patients do not respond to treatments with immune checkpoint inhibitors, partly because of the lack of tumor-infiltrating effector T cells. Cancer vaccines may prime patients for treatments with immune checkpoint inhibitors by inducing effector T-cell infiltration into the tumors and immune checkpoint signals. The combination of cancer vaccine and an immune checkpoint inhibitor may function synergistically to induce more effective antitumor immune responses, and clinical trials to test the combination are currently ongoing. | Jennifer Kleponis Richard Skelton Lei Zheng | 2015 | Cancer Biology & Medicine2015，12，3： | 8 |
| 2 | Tissue differential expression of lycopene β-cyclase gene in papaya显示文摘Carotene pigments in flowers and fruits are distinct features related to fitness advantages such as attracting insects forpollination and birds for seed dispersal.In papaya,the flesh color of the fruit is considered a quality trait that correlateswith nutritional value and is linked to shelf-life of the fruit.To elucidate the carotenoid biosynthesis pathway in papaya,we took a candidate gene approach to clone the lycopene β-cyclase gene,LCY-B.A papaya LCY-B ortholog,cpLCY-B,was successfully identified from both cDNA and bacterial artificial chromosome(BAC)libraries and complete genomicsequence was obtained from the positive BAC including the promoter region.This cpLCY-B shared 80% amino acididentity with citrus LCY-B.However,full genomic sequences from both yellow- and red-fleshed papaya were identical.Quantitative real-time PCR(qPCR)revealed similar levels of expression at six different maturing stages of fruits forboth yellow-and red-fleshed genotypes.Further expression analyses of cpLCY-B showed that its expression levels wereseven- and three-fold higher in leaves and,respectively,flowers than in fruits,suggesting that cpLCY-B is down-regulatedduring the fruit ripening process. | Rachel L Skelton Qingyi Yu Rajeswari Srinivasan Richard Manshardt Paul H Moore Ray Ming | 2006 | Cell Research2006，16，8： | 8 |
| 3 | 多伦多的住房:规划在商品房和社会住房方面所面临的挑战显示文摘加拿大一直以来都着重于私人住房(即商品房)市场的开发,在政府的适度干预之下,多伦多的住房市场不仅提供了大量的住宅,而且住宅的类型和产权形式也被市场所认可。然而,在现有市场条件下,仍然有许多人的住房需求得不到充分满足。在有些情况下,还明显地需要政府通过规范对市场进行进一步的干预,以保证建设高质量的生活环境。多伦多社会住厉的建设由于缺少来自政府的鼎力支持,目前也面临很多困难。地方规划师一直在努力地工作,在实现社会住房的民主管治、改进管理方式,以及改善住房水平方面都做出了许多尝试。目前在多伦多,无论是商品房还是社会住房都需要政府在行政和规划方面予以支持和帮助。 | Ian Skelton 严宁 | 2005 | 国外城市规划2005，，2： | 3 |
| 4 | Peripheral interventions and antiplatelet therapy: Role in current practice显示文摘Peripheral arterial disease(PAD) is a common disorder associated with a high risk of cardiovascular mortality and continues to be under-recognized. The major risk factors for PAD are similar to those for coronary and cerebrovascular disease. Management includes exercise program, pharmacologic therapy and revascularization including endovascular and surgical approach. The optimal revascularization strategy, endovascular or surgical intervention, is often debated due to the paucity of head to head randomized controlled studies. Despite significant advances in endovascular interventions resulting in increased utilization over surgical bypass, significant challenges still remain. Platelet activation and aggregation after percutaneous transluminal angioplasty of atherosclerotic arteries are important risk factors for re-occlusion/restenosis and life-threatening thrombosis following endovascular procedures. Antiplatelet agents are commonly prescribed to reduce the risk of myocardial infarction, stroke and death from cardiovascular causes in patients with PAD. Despite an abundance of data demonstrating efficacy of antiplatelet therapy in coronary artery disease and cerebrovascular disease, there is a paucity of clinical information, clinical guidelines and randomized controlled studies in the PAD population. Hence, data on antiplatelet therapy in coronary interventions is frequently extrapolated to peripheral interventions. The aim of this review article is to elucidate the current data on revascularization and the role and duration of antiplatelet and anticoagulant therapy in re-vascularized lower limb PAD patients. | Pahul Singh Yenal Harper Carrie S Oliphant Mohamed Morsy Michelle Skelton Raza Askari Rami N Khouzam | 2017 | World Journal of Cardiology2017，9，7： | 2 |
| 5 | All Controllers for the General H∞ Control Problem:LMI Existence Conditions and State Space Formulas显示文摘 | Iwasaki T Skelton R E | 1994 | Automatics1994，30，8： | 1 |
| 6 | Bright light treatment has limited effect in subjects over 55 years with mild early morning awakening显示文摘 | Pallesen S Nordhus IH Skelton SH | 2005 | Percept Mot Skills2005，101，3： | 1 |
| 7 | Total parenteral nutrition显示文摘 | Peden VH Witzleben CL Skelton MA | 1971 | J Pediatr1971，78，1： | 1 |
| 8 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 9 | Serum sickness aftertreatment with rabbit antjthymoeyte globulin in kidney transplant recipients with previous rabbit exposure显示文摘 | BOOTHPUR R HARDINGER K I SKELTON R M | 2010 | Am J Kidney Dis2010，55，1： | 1 |
| 10 | The bausch- inger effect, masing model and the Ramberg-Osgood relation for cyclic deformation in metals 显示文摘 | Skelton R P Maier H J Christ H J | 1997 | Materi- als Science and Engineering1997，238，2： | 1 |
| 11 | All fixed order H∞controllers:Observer-based structure and covariance bounds 显示文摘 | Iwasaki T Skelton R E | 1995 | IEEE Trans on Automatic control1995，40，3： | 1 |
| 12 | The importance of multiaxial stress in creep deformation and rupture显示文摘 | GOODALL I W SKELTON R P | 2004 | Fatigue and Fracture of Engi- neering Material and Structure2004，27，1： | 1 |
| 13 | A large-scale com- putational study of inhibitor risk in non severe haemophilia A显示文摘 | Shepherd AJ Skelton S Sansom CE | 2014 | Br J Haematol2014，168，3： | 1 |
| 14 | Perspectives in dermatopathology:telomeres and telomerase in ageing and cancer;with emphasis on cutaneous disease显示文摘 | Smith KJ Germain M Skelton H | 2000 | J Cutan Pathol2000，27，1： | 1 |
| 15 | All controllers for the general H∞ control problems:LMI existence conditions and state space formulas显示文摘 | IWASAKI T SKELTON R E | 1994 | Automatica1994，30，8： | 1 |
| 16 | Mean-square small gain the- orem for stochastic control: Discrete-time 显示文摘 | JIANBO L SKELTON R E | 2002 | IEEE Transactions on Automatic Control2002，47，3： | 1 |
| 17 | Triaxially woven fabrics: their structure and properties 显示文摘 | SKELTON J | 1971 | Textile Research Journal1971，41，8： | 1 |
| 18 | Audit of ceil salvage use in obstetric patients: adding experience 显示文摘 | Parry N Junghans C Skelton V | 2010 | Int J Obstet Anesth2010，19，2： | 1 |
| 19 | Nonspecific messenger RNA of α-fetoprotein in peripheral blood in detecting early spread of hepatocellular carcinoma in black Africans显示文摘 | KEDDA M A KEW M C SKELTON M | 1998 | Gastroenterol Hepatol1998，13，3： | 1 |
| 20 | Desmoplastic malignant melanoma显示文摘 | Skelton H G Smith K L Laskin W B | 1995 | J Am Acad Dermatol1995，32，51： | 1 |
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