|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Colorectal cancer tumour markers and biomarkers:Recenttherapeutic advances显示文摘Colorectal cancer(CRC) is the second most commonly diagnosed cancer among females and third among males worldwide. It also contributes significantly to cancer-related deaths, despite the continuous progress in diagnostic and therapeutic methods. Biomarkers currently play an important role in the detection and treatment of patients with colorectal cancer. Risk stratification for screening might be augmented by finding new biomarkers which alone or as a complement of existing tests might recognize either the predisposition or early stage of the disease. Biomarkers have also the potential to change diagnostic and treatment algorithms by selecting the proper chemotherapeutic drugs across a broad spectrum of patients. There are attempts to personalise chemotherapy based on presence or absence of specific biomarkers. In this review, we update review published last year and describe our understanding of tumour markers and biomarkers role in CRC screening, diagnosis, treatment and follow-up. Goal of future research is to identify those biomarkers that could allow a non-invasive and cost-effective diagnosis, as well as to recognise the best prognostic panel and define the predictive biomarkers for available treatments. | Gustaw Lech Robert Słotwiński Maciej Słodkowski Ireneusz Wojciech Krasnodębski | 2016 | World Journal of Gastroenterology2016，22，5： | 33 |
| 2 | Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases显示文摘BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. | Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 15 |
| 3 | 轮铲式挖掘机新一代驾驶室隔震系统的优化显示文摘提出新一代驾驶室计算机辅助设计的一些观点,重点关注驾驶室隔振系统的原始设计方案,它由挖掘悬臂连同驾驶室悬臂组成.用有限元法对驾驶室动态特性进行了分析,在虚拟模型数值分析的基础上形成一个方案,随后建立一个带有隔振系统的驾驶室原型样模,实体振动测量提供了非常令人满意的结果. | Eugeniusz Rusi■ski Tadeusz Lewandowski Wiktor S■omski 吕新生 | 2005 | 工程设计学报2005，12，3： | 2 |
| 4 | Margins and Market Integrity:Margin setting for stock Index Futures and Optins显示文摘 | Figlew Ski S | 1984 | The Journal Futures Markets1984，，4： | 1 |
| 5 | Sensitivity to disinfectants of methicillin resistant staphylococcus aureus strains (MRSA) and gentamicin resistant strains显示文摘 | Wi(s)niewska K Galiński J Piechowicz L | | 0，，3： | 1 |
| 6 | Influence of microwave radiation on bacterial community structure inbiofilm显示文摘 | ZIELIN SKI M CIESIELSKI S CYDZIK-KWIATKOWSKA A | 2007 | Process Biochemistry2007，42，8： | 1 |
| 7 | Melanoma of the nasal septum显示文摘 | Korska-Szczechowska S Skorek A Babiński D | 2013 | Otolaryngol Pol2013，67，2： | 1 |
| 8 | Evidence for circulating bone marrowderived endothelial cells显示文摘 | Ski Q Rafii S Wu MH | 1998 | Blood1998，92，2： | 1 |
| 9 | Effect of supportactivation on the kinetics of indole hydrodenitrogenationover mesoporous carbon black composites-supported molybdenumcarbide显示文摘 | Sayag C Suppan S Trawczyński J | 2002 | Fuel Processing Technology2002，7778，： | 1 |
| 10 | Dose-response andrecovery of Org 9426 under enflurane anesthesia显示文摘 | Bartkow ski RR Witkow ski TA Azad S S | 1990 | Anesthesiology1990，，： | 1 |
| 11 | Post-thyroidectomy hem- orrhage显示文摘 | Cichon S Anie|ski R Orlicki P | 2002 | Przegl Lek2002，59，7： | 1 |
| 12 | Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy显示文摘 | Barczy(n)ski M Konturek A Cicho(n) S | 2009 | Br J Surg2009，96，3： | 1 |
| 13 | Role of endogenous nitric oxide in the control of exocrine and endocrine pancreatic secretion显示文摘 | Bilski J Konturek S J Bielański W J | 1995 | Physiol Pharmacol1995，46，4： | 1 |
| 14 | Application of computer vision systems for estimation of fat content in poultry meat显示文摘 | Marta Chmiel Miros?aw S?owiński Krzysztof Dasiewicz | 2011 | Food Control2011，，8： | 1 |
| 15 | Melatonin and cortisol profiles in patients with pituitary tumors显示文摘 | Zielonka D Sowiński J Nowak S | 2015 | Neurol Neurochir Pol2015，49，1： | 1 |
| 16 | Prediction of general mental ability based on neural oscillation measures of sleep显示文摘 | RóBERTBóDIZS TAMáSKIS ALPáR SáNDORLáZáR LINDAHAVRáN PéTERRIGó ZSóFIACLEMENS PéTERHALáSZ | 2005 | Journal of Sleep Research2005，，3： | 1 |
| 17 | Randomized clinical trialof visualization versus neuromonitoring of recurrent laryngealnerves during thyroidectomy显示文摘 | barczy n ski M konturek A Cichofi S | 2009 | Br J Surg2009，96，3： | 1 |
| 18 | Usefulness of 3D transperineal ultrasound in severe stenosis of the anal canal: preliminary experience in four cases显示文摘 | M. Ko?odziejczak G. A. Santoro R. Z. S?apa T. Szopiński I. Sudo?-Szopińska | 2014 | Techniques in Coloproctology2014，，： | 1 |
| 19 | Minimally invasive video-assisted thyreoidectomy (MIVAT) with and without use of harmonic scalpel--a randomized study显示文摘 | Barczyński M Konturek A Cichoń S | 2008 | Langenbecks Arch Surg2008，393，5： | 1 |
| 20 | Winter foraging of threatened cranes in the Demilitarized Zone of Korea:Behavioral evidence for the conservation importance of unplowed rice fields显示文摘 | Lee S D Jaboński P G Higuchi H | 2007 | Biological Conservation2007，138，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员