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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 3 | An exploratory study of the information model relation and customer requirement 显示文摘 | PAPACHRISTORS S SKOURI K | 2004 | International Journal of Operations & Production Management2004，22，9： | 1 |
| 4 | Prognostic role of pulmonary arterial capacitance in advanced heart failure显示文摘 | Dupont M Mullens W Skouri HN | 2012 | Circ Heart Fail2012，5，6： | 1 |
| 5 | Abnornml assemblies and subunit exchange of alphaB-crystallin R120 mutants could be associated with destabilization of the dimerie substructure 显示文摘 | Michiel M Skouri Panet F Duprat E | 2009 | Biochemistry2009，48，： | 1 |
| 6 | Optimal ordering quantities for substitutable products with stock-de- pendent demand显示文摘 | KROMMYDA I P SKOURI K KONSTANTARAS I | 2015 | Applied Mathematical Modelling2015，，1： | 1 |
| 7 | An optimal replenishment policy for deteriorating items with time-varying de- mand and partial exponential type backlog- ging显示文摘 | Papachristos S Skouri K | 2000 | Operational Research Letter2000，27，： | 1 |
| 8 | An inventory model with deteriorating items,quantity discount,pricing and time-dependent partial backlogging显示文摘 | Papachristos S Skouri K | 2003 | Int J Production Economics2003，83，3： | 1 |
| 9 | A continuous review inventory model,with deteriorating items,time-varying demand,linear replenishment cost,partially time-varying backlogging显示文摘 | Skouri K Papachristos S | 2002 | Applied Mathematical Modeling2002，26，5： | 1 |
| 10 | An optimal replenishment policy for deteriorating items with time-varying demand and partial-exponential-type-backlogging显示文摘 | Papachristos S Skouri K | 2000 | Operations Research Letters2000，27，4： | 1 |
| 11 | Inventory models withramp type demand rate, partial backlogging and Weibull deterioration rate显示文摘 | Skouri K Konstantaras I Papachristos S Ganas I | 2009 | European Journal of Operational Research2009，192，1： | 1 |
| 12 | Elevated intra-abdominal pressure in acute decompensated heart failure显示文摘 | Mullens W Abrahams Z Skouri HN | 2008 | J Am Coll Cardiol2008，51，： | 1 |
| 13 | An inventory model with deteriorating items, quantity discount, pricing and time-dependent partial backlogging显示文摘 | Papachristos S Skouri K | 2003 | International Journal of Production Economics2003，83，： | 1 |
| 14 | An inventory model with deteriorating itenas, quantity discount, pricing and time-dependent partial backlogging显示文摘 | Papachristos S Skouri K | 2003 | International Journal of Production Economics2003，83，3： | 1 |
| 15 | An optimal replenishment policy for deteriorating items with time varying demand and partial-exponential type-backlogging显示文摘 | Papachristos S Skouri K | 2000 | Operation Research Letters2000，27，4： | 1 |
| 16 | A randomized single-blind trial of standard diet versus fiber-free diet with polyethylene glycol electrolyte solution for colonoscopy preparation显示文摘 | A. Soweid A. Kobeissy F. Jamali M. El-Tarchichi A. Skoury H. Abdul-Baki L. El-Zahabi A. El-Sayyed K. Barada A. Sharara F. Mourad A. Arabi | 2010 | Endoscopy2010，，08： | 1 |
| 17 | Elevated intra- abdominal pressure in acute decompensated heart failure:a potential contributor to worsening renal function?显示文摘 | Mullens W Abrahams Z Skouri HN | 2008 | J Am Coll Cardiol2008，51，3： | 1 |
| 18 | An inventory model with deteriorating items,quantity discount,pricing and time dependent partial backlogging显示文摘 | Papachristos S Skouri K | 2003 | International Journal of Production Economics2003，83，： | 1 |
| 19 | An inventory model with deteriorating items,quantity discount,pricing and time-dependent partial back logging显示文摘 | Papachristos S Skouri K | 2003 | International Journal of Production Economics2003，83，： | 1 |
| 20 | Lot sizing for a recoverabke product with inspection and sorting显示文摘 | Kinstantaras I Skouri K Jaber M Y | 2010 | Comptuer&Industial Engineering2010，58，： | 1 |
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