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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Cellular and molecular aspects of gastric cancer显示文摘胃的癌症与变的负担仍然是一个全球杀手从发展了到发展中的世界。癌症沿着被定义由的一个多级式的过程发展不同组织学并且 pathophysiological 阶段。几基因、渐成说的改变调停从一个的转变上演到另外一个,这些在 oncogenes 包括变化,瘤压制或基因和房间骑车并且错配修理基因。在对胃的癌症的战斗的最重要的进展为这癌症作为最重要的获得的病因论的代理人与 Helicobacter pylori (H pylori ) 的角色的识别来了。最近的工作在阐明上集中了位于肿瘤的过程下面的复杂 host/microbial 相互作用。现在进这癌症的致病和阻止并且根除的前景有可观的卓见疾病成为了现实。也许更重要地, H 导致 pylori 的胃的致癌作用的学习为理解更复杂的人的癌症提供一个范例。在这评论,我们检验位于 H 下面的分子、细胞的事件导致 pylori 的胃的癌症。 | Malcolm G Smith Georgina L Hold Eiichi Tahara Emad M El-Omar | 2006 | World Journal of Gastroenterology2006，12，19： | 29 |
| 3 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 4 | Restriction fragment length polymorphism evaluation of six peanut species within the Arachis section显示文摘 | Paik Ro O G Smith R L Knauft D A | 1992 | Theor Appl Genet1992，84，： | 2 |
| 5 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 6 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 7 | Meta - analysis of Research on Class Size and Achievement 显示文摘 | Class G V Smith M L | 1979 | Educational Evaluation and Policy Analysis1979，，1： | 1 |
| 8 | Pre-oxygenation and the parturient patient 显示文摘 | Russell G N Smith C L Snowdon S L | 1987 | Anaesthesia1987，42，： | 1 |
| 9 | The air toxics health effects database (ATHED)显示文摘 | WOODALL G M SMITH R L | 2008 | Toxicology and Applied Pharmacology2008，233，： | 1 |
| 10 | TGF-beta2 activates proliferative scar fibroblasts显示文摘 | Smith P Mosiello G Deluca L | 1999 | J Surg Res1999，82，2： | 1 |
| 11 | Effects of water stress on fruit quality attributes of Kiwifruit显示文摘 | Miller S A Smith G S Bolding H L | 1998 | Annals of Botany1998，81，： | 1 |
| 12 | If Smallpox Strikes Portland显示文摘 | Chris L Barrett Sphen G Eubank James P Smith | 2005 | Scientific American (S0036-8733)2005，292，3： | 1 |
| 13 | Evaluation of trickle-bed air biofilter performance for styrene removal显示文摘 | Sorial G A Smith F L Suidan M T | 1998 | Water Research1998，32，5： | 1 |
| 14 | High refractive index hybrid ceramet materials prepared from tetraisoprpoxide and poly (arylene ether phosphine oxide) through sol-gel processing 显示文摘 | WANG B WILKES G L SMITH C D | 1991 | Polymer Comm1991，32，1： | 1 |
| 15 | Typing of dengue vi- ruses in clinical specimens and mosquitoes by single-tube multiplex reverse transcriptase PCR显示文摘 | Harris E Roberts T G Smith L | 1998 | J Clin Microbiol1998，36，： | 1 |
| 16 | Factors influencing changes in articular cartilage follow- ing hemiarthroplasty in sheep显示文摘 | van der Meulen M C Beaupre G S Smith R L | 2002 | J Orthop Res2002，20，4： | 1 |
| 17 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 18 | Metabolic relations to temperatures in the copepods Diaptomus dorsalis and Mesocyclopes edax from North-Central Texas显示文摘 | Smith G A Fitzpatrick L C Pearson W D | | 0，，： | 1 |
| 19 | Effects of market and regulatory changes on livestock manure management in southern Alberta显示文摘 | SMITH E G CARD G YOUNG D L | 2006 | Canadian Journal of Agricultural Conomics2006，54，2： | 1 |
| 20 | Biosynthesis of an antifungal oligopeptide in Burkholderia contaminans strain MS14显示文摘 | Gu G Smith L Wang N | 2009 | Biochemical and Biophysical Research Communications2009，380，： | 1 |
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