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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 3 | Chronic hepatitis C is a common associated with hepatic granulomas显示文摘AIM: To determine the most frequent etiologies of hepatic epithelioid granulomas, and whether there was an association with chronic hepatitis C virus (HCV). METHODS: Both a retrospective review of the pathol-ogy database of liver biopsies at our institution from 1996 through 2006 as well as data from a prospective study of hepatic fibrosis markers and liver biopsies from 2003 to 2006 were reviewed to identify cases of hepatic epithelioid granulomas. Appropriate charts, liver biopsy slides, and laboratory data were reviewed to determine all possible associations. The diagnosis of HCV was based on a positive HCV RNA. RESULTS: There were 4578 liver biopsies and 36 (0.79%) had at least one epithelioid granuloma. HCV was the most common association. Fourteen patients had HCV, and in nine, there were no concurrent conditions known to be associated with hepatic granulomas. Prior interferon therapy and crystalloid substances from illicit intravenous injections did not account for the fi nding. There were hepatic epithelioid granulomas in 3 of 241 patients (1.24%) with known chronic HCV enrolled in the prospective study of hepatic fibrosis markers. CONCLUSION: Although uncommon, hepatic granulomas may be part of the histological spectrum of chronic HCV. When epithelioid granulomas are found on the liver biopsy of someone with HCV, other clinically appropriate studies should be done, but if nothing else is found, the clinician can be comfortable with an HCV association. | Ned Snyder Juan G Martinez Shu-Yuan Xiao | 2008 | World Journal of Gastroenterology2008，14，41： | 2 |
| 4 | Effect of air and oxygen content on the dielectric barrier discharge decomposition of chlorobenzene 显示文摘 | ANDERSON G K | 1998 | IEEE Trans Plasma Sci1998，26，6： | 1 |
| 5 | Nutrogen/potassium fertilization rations for bermudagrass turf显示文摘 | Snyder G H Cisar J L | 2000 | Crop Science2000，40，6： | 1 |
| 6 | Control ofcolumn temperature in reversed-phase liquid chromatography显示文摘 | Wolcott R G Dolan J W Snyder L R | 2000 | J ChromatogrA2000，869，12： | 1 |
| 7 | Cytokine generationin stored platelet concentrates显示文摘 | Srack G Snyder EL | 1994 | Transfusion1994，34，1： | 1 |
| 8 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 9 | Redescription of the frog bladder fluke Gorgoderina attenuata from the north- ern leopard frog, Rana pipiens 显示文摘 | Bolek M G Snyder S D Janovy J Jr | 2009 | J Parasitol2009，95，3： | 1 |
| 10 | Iterative deblurring for CT metal artifact reduction显示文摘 | Wang G Snyder DL O'sullivan JA | 1996 | IEEE Transactions on Medical Imaging1996，15，5： | 1 |
| 11 | Thermoelectric microdevice fabricated by a MEMS-like electrochemical process 显示文摘 | Snyder G J Lira J R Huang C K | 2003 | Nature Materials & Design2003，2，5： | 1 |
| 12 | Toxicity and Repellency of Hot Pepper Extracts to Spider Mite显示文摘 | ANTONIOUS G F MEYER J E SNYDER J C | 2006 | Journal of Environmental Science and Health-part B Pesticides Food Contaminants and Agricultural Wastes2006，41，8： | 1 |
| 13 | Reevaluation of PbTel -xlx as High Performance n-type Thermoelectric material 显示文摘 | LaLonde A D Pei Y Snyder G J | 2011 | Energy & Envi- ronmental Science2011，4，6： | 1 |
| 14 | 显示文摘 | Mo Y G Dillon R O Snyder P G | 1999 | Thin Solid Films1999，355，： | 1 |
| 15 | International symposium:Recent advances in benzene toxicity显示文摘 | Bird M G Greim H Snyder R | 2005 | Chemico-Biological Interactions2005，153，： | 1 |
| 16 | Complex thermoeleetric materials显示文摘 | Snyder G J Toberer E S | | 0，，2： | 1 |
| 17 | Methyl bromide recovery on activated carbon with repeated adsorption and electrothermal regeneration显示文摘 | Jon D Snyder James G Leeseh | 2001 | Ind Eng Chem Res2001，，40： | 1 |
| 18 | Disordered zinc in Zn4Sb3 with phonon glass, electron crystal thermoelectric properties显示文摘 | SNYDER G J CHRISTENSEN M NISHIBORI E | 2004 | Nature Mater2004，3，： | 1 |
| 19 | Synthesis and opioid activity of Dynorphin A- (1-13) NH2 analogues containing cis- and trans-4- aminocyclohexanecarboxylic acid 显示文摘 | Snyder K R Murray T F DeLander G E | 1993 | J Med Chem1993，36，8： | 1 |
| 20 | The relationship of blood product ratio to mortality:survival benefit or survival bias显示文摘 | Snyder CW Weinberg JA McGwin G | 2009 | J Trauma2009，66，2： | 1 |
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