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| 1 | Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults显示文摘AIM: To evaluate the effects of three potentially anti- inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. METHODS: A total of 62 volunteers participated in this randomized, double-blind and placebo-controlled parallel group intervention study. The volunteers were randomized to receive a milk-based drink containing either Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis ssp. lactis Bb12 (Bb12), or Propionibacterium freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS: The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo. IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION: In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults. | Riina A Kekkonen Netta Lummela Heli Karjalainen Sinikka Latvala Soile Tynkkynen Salme Jrvenp Hannu Kautiainen Ilkka Julkunen Heikki Vapaatalo Riitta Korpela | 2008 | World Journal of Gastroenterology2008，14，13： | 6 |
| 2 | Determinants of technical efficiency among dairy farms in Wisconsin显示文摘 | Cabrera V E Soils D Corral J | 2010 | Journal of Dairy Science2010，93，1： | 1 |
| 3 | Optical sensor-based algorithm for corp nitrogen fertilization显示文摘 | Raun W R Soil J B Stone M L | 2005 | Soil Science and Plant Analysis2005，36，1920： | 1 |
| 4 | Soil respiration and the global carbon cycle显示文摘 | soil nematode communities in a Soil Biology and Biochemistry Schlesinger W H Andrews J A | 2000 | Biogeochemistry2000，48，1： | 1 |
| 5 | A model of the diffusion and reaction of O2, Fe^2+, H^+ and HCO3^- in soils and a sensitivity analysis of the model显示文摘 | Kirk G J D Coupled diffusion and oxidation of ferrous iron in soil II | 1990 | J Soil Sci1990，41，： | 1 |
| 6 | in a soil contaminated by pyritic mine waste显示文摘 | Walker D J Clemente R Bernal ME Contrasting effects of manure and compost on soil pH heavy metal availability and growth of Chenopodium album L | 2004 | Chemosphere2004，57，： | 1 |
| 7 | Assessment of interac- tions between land use change and carbon and nutrient fluxes in Ecuador 显示文摘 | for soil CO2 production and Agricuhural and Forest Mete- Priess J A Koning G H Veldkam p A | 2001 | Agriculture Ecosystem Environment2001，85，： | 1 |
| 8 | Development of stability ratios for tunnels driven in clay 显示文摘 | Stability of clay at vertical Soil Mechanics & Foundation Attewell 19 B Boden J B | 1971 | Tunnels & Tunnelling International1971，31，3： | 1 |
| 9 | 4GHZ Frequency显示文摘 | Wang J R Choudhury B J Remote Sensing of Soil Moisture Content Over Bare Field at 1 | 1981 | Joumal of Geophysical Re search1981，86，： | 1 |
| 10 | detergent formation and performance显示文摘 | TONGCUMPOU C ACOSTA Microemulsion formation and E J QUENCER L B etal detergency with oily soil Ⅱ | 2003 | Journal of Surfactant and Detergent2003，6，3： | 1 |
| 11 | Social comparison and confidence: When thinking you' re better than average predicts overconfidence (and when it does not) 显示文摘 | Larrick R P Burson K A Soil J B | 2007 | Organizational Behavior and Human Decision Processes2007，102，1： | 1 |
| 12 | Short-term caused by urine patches of different sizes 显示文摘 | ORWIN K H BERTRAM J E CLOUGH T J et consequences of spatial heterogeneity in soil nitrogen al | 2009 | Applied Soil Ecology2009，42，： | 1 |
| 13 | hydraulic low processes 显示文摘 | Simu'nek J van Genuchten M T Gribb M Parameter estimation of unsaturated soil properties from transient Tillage Research 1998 M | 1998 | Soil & 471998，2736，： | 1 |
| 14 | Relation- nitrogen and phosphorus availability, and pasture growth under organic and con- ventional management显示文摘 | Parffit R L Yeates G W ships between soil biota Ross D J | 2005 | Applied Soil Ecology2005，28，1： | 1 |
| 15 | Use of spectral radiance for correcting in-season fertilizer nitrogen deficiencies in winter wheat显示文摘 | Stone M L Soile J B Raun W R | 1996 | Transactions of theASAE1996，39，5： | 1 |
| 16 | Kurstaki en- dotoxin显示文摘 | Donegan K K Palm C J Fieland V J Changes in levels spe- cies and DNA fingerprints of soil microorganisms associated with cotton expressing the Bacillus thuringiensis vat | 1995 | Applied Soil Ecology1995，2，2： | 1 |
| 17 | A characterization of pH- regulated dimorphism in Candida albicans显示文摘 | Buffo J Herman M A Soil D R | 1984 | Mycopathologia1984，85，12： | 1 |
| 18 | Relationship between desorption, hysteresis, and the chemical characteristics of organic domains显示文摘 | HUANG W WEBER W J A distributed reactivity model for sorption by soils and sediments 10 | 1997 | Environ Sci Technol1997，31，： | 1 |
| 19 | The MPG illusion 显示文摘 | Larrick R P Soil J B | 2008 | Science2008，320，6： | 1 |
| 20 | 14-3-3 proteins and plant development显示文摘 | Fulgosil H Soil J de Faria Maraschin S | 2002 | Plant Mol Biol2002，50，： | 1 |
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