| 1 | Intramolecular aromatic-ring stacking interaction of ternary Zn(UTP)L^(2-) complexes显示文摘THE mechanism of the action of the classic platinum antitumor drugs can be interpreted accord-ing to their bidentate, bifunctional interaction with the DNA of the tumor cell, resulting in in-hibition of the DNA replication. Recently, it was found that a new class of compounds withthe general formula cis-[Pt(NH3)2(N-het)Cl]Cl(N-het is a heteroaromatic N-base like pyri-dine) show effective antitumor activities. However, two possible mechanisms of action | LE Xueyi, WU Fuhai, SONG Fenyun and Jl Liangnian1.Department of Chemistry, Zhongshan University, Guangzhou 510275, China State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2. Department of Hygienics, Guangdong Pharmaceutical School, Guangzhou 510224, China | 1997 | Chinese Science Bulletin1997，42，14： | 4 |
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