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| 1 | Skeletal myoblast based delivery of angiogenic growth factors:a comparison between angiopoietin-1 and VEGF gene delivery for therapeutic angiogenesis in the heart显示文摘Objectives This study investigated the efficacy of human skeletal myoblasts (SkM) mediated either human vascular endothelial growth factor-165 (hVEGF165) or angiopoietin-1 (Ang-1) on vascular development and myocardial regional perfusion. Methods A porcine heart model of chronic infarction was created in 28 female swine by coronary artery ligation. The animals were randomized into: (1) group-1, DMEM injected (n=6), (2) group-2, Ad-null transduced SkM transplanted (n=6), (3) group-3, Ad-hVEGF165 transduced SkM transplanted (n=8), and (4) group-4, Ad-Ang-1 transduced SkM (n=8). Three weeks later, 5 ml DMEM containing 3×108 SkM carrying exogenous genes were intramyocardially injected into 20 sites in left ventricle in groups-2, -3 and -4. Animals in group-1 were injected 5 ml DMEM without cells. Animals were kept on 5 mg/kg cyclosporine per day for 6 weeks. Regional blood flow was measured using fluorescent microspheres. The heart was explanted at 2, 6 and 12 weeks after transplantation for histological studies. Results Histological examination showed survival of lac-z expressing myoblasts in host tissue. Capillary density based on Von Willebrand factor-VIII (vWF-VIII) at low power field (×100) was 57.13±11.85 in group-3 at 6 weeks and declined to 32.1±5.21 at 12 weeks, while it was 39.9±10.26 at 6 weeks and increased to 45.14±6.54 at 12 weeks in group-4. The mature blood vessel index was highest in group- 4 at 6 and 12 weeks after transplantation. The regional blood flow in the center and peri-infarct area was significantly increased in animals of groups-3 and -4. Conclusions SkM carrying either hVEGF165 or Ang-1 induced neovascularization with increased blood flow. Ang-1 overexpression resulted in mature and stable blood vessel formation and may be a more potent arteriogenic inducer for neovascularization. | Husnain Kh Haider In-Chin Song Peter K Law Eugene KW Sim | 2006 | Journal of Geriatric Cardiology2006，3，3： | 3 |
| 2 | Activation of Toll - like receptor 4 is associated with insulin resistance in adipocytes显示文摘 | Song M J Kim KH Yoon JM | 2006 | Biochem Biophys Res Commun2006，346，3： | 1 |
| 3 | Prognostication of recovery in patients with acute ischemic stroke through the use of brain SPECT with Technetium-99m-labeled metronidazole显示文摘 | Song HC Bom HS Cho KH | 2003 | Stroke2003，34，4： | 1 |
| 4 | Diffusion-Weighted MRI in cystic or necrotic intracranial lesions显示文摘 | Park SH Chang KH Song IC | 2001 | Neuroradiology2001，42，7： | 1 |
| 5 | Brain abscess and necrotic or cystic brain tumor: discrimination with signal intensity on diffusion weighted MR imaging 显示文摘 | Koung YJ Chang KH Song IC | 1998 | AJR1998，171，6： | 1 |
| 6 | Diagnostic useluiness of a T-cell based assay for extrapulmonary tuberculosis in inmmunocompromised patients显示文摘 | Kim SH Song KH Choi SJ | 2009 | Am J Med2009，122，2： | 1 |
| 7 | Incidence of overt proteinuria and coronary artery disease in patients with type 2 diabetes mellitus: the role of microalbuminuria and retinopathy显示文摘 | Kim KS Koh JM Song KH | 2004 | Diabetes Res Clin Pract2004，65，2： | 1 |
| 8 | Celecoxib enhances radiosensitivity in medulloblastoma-derived CD133-positive cells显示文摘 | Chen KH Hsu CC Song WS | 2010 | Childs Nerv Syst2010，26，11： | 1 |
| 9 | Delayed encephalopathy of acute carbon monoxide intoxication:diffusivity of cerebral white matter lesions显示文摘 | Kim JH Chang KH Song IC | 2003 | Am J Neuroradiol2003，24，： | 1 |
| 10 | Activation of the hexosamine pathway leads to deterioration of pancreatic: β-cell function through the induction of oxidative stress 显示文摘 | Kaneto H Xu G Song KH | 2001 | J Biol Chem2001，276，31： | 1 |
| 11 | Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress 显示文摘 | Kaneto H Xu G Song KH | 2001 | J Biol Chem2001，276，31： | 1 |
| 12 | Role of F - FDG PET scans inpatients with helicobacter pylori - infected gastric low - gradeMALT lymphoma显示文摘 | Song KH Yun M Kim JH | 2011 | Gut Liver2011，5，3： | 1 |
| 13 | Diagnostic usefulness of a T-cell- based assay for extrapulmonary tuberculosis in immunocompromised patients 显示文摘 | Kim SH Song KH Choi S J | 2009 | Am J Med2009，122，2： | 1 |
| 14 | Activation of Toll-like re-ceptor 4 is associated with insulin resistance in adipocytes显示文摘 | Song MJ Kim KH Yoon JM | 2006 | Biochemical and Biophysical Research Communications2006，46，： | 1 |
| 15 | Fractalkine and its re?ceptor mediate extracellular matrix accumulation in dia?betic nephropathy in mice显示文摘 | Song KH ParkJ ParkJH | 2013 | Diabetologia2013，，： | 1 |
| 16 | Diagnostic usefulness of a T- celbbased assay for extrapulmonary tuberculosis in immunoeom- promised patients显示文摘 | Kim SH Song KH Choi SJ | 2009 | Am J Med2009，122，2： | 1 |
| 17 | Diagnostic usefulness ofa T - cell - based assay for extrapulmonary tuberculosis in promised patiems显示文摘 | Kim SH Song KH Choi SJ | 2009 | Arch Intern Med2009，122，2： | 1 |
| 18 | Rural -urban migration and urbanization in China: evidence from time series and cross section analy-ses显示文摘 | Zhang KH Song SF | 2003 | China Economic Review2003，14，4： | 1 |
| 19 | Benign tracheobronchial stenoses: long-term clinical experience with balloon dilation 显示文摘 | Lee KH Ko GY Song HY | 2002 | J Vasc Interv Radiol2002，13，9： | 1 |
| 20 | Specific endothelial binding and tumor uptake of radiolabeled angiostain 显示文摘 | Lee KH Song SH Paik JY | 2003 | Eur J Nucl Med Mol Imaging2003，30，7： | 1 |
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