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| 1 | Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification显示文摘Heterotopic ossification(HO)is a debilitating condition characterized by the pathologic formation of ectopic bone.HO occurs commonly following orthopedic surgeries,burns,and neurologic injuries.While surgical excision may provide palliation,the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone.Based on these clinical observations,we set out to examine the role of vascular signaling in HO.Vascular endothelial growth factor A(VEGFA)has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis.Our findings,using a validated mouse model of HO,demonstrate that HO lesions are highly vascular,and that VEGFA is critical to ectopic bone formation,despite lacking a contribution of endothelial cells within the developing anlagen. | Charles Hwang Simone Marini Amanda KHuber David MStepien Michael Sorkin Shawn Loder Chase APagani John Li Noelle DVisser Kaetlin Vasquez Mohamed AGarada Shuli Li Jiajia Xu Ching-Yun Hsu Paul BYu Aaron WJames Yuji Mishina Shailesh Agarwal Jun Li Benjamin Levi | 2019 | Bone Research2019，7，4： | 4 |
| 2 | Origin of ultrafast growth of monolayer WSe_(2) via chemical vapor deposition显示文摘The ultrafast growth of large-area,high-quality WSe2 domains with a compact triangular morphology has recently been achieved on a gold substrate via chemical vapor deposition.However,the underlying mechanism responsible for ultrafast growth remains elusive.Here,we first analyze growth processes and identify two possible pathways that might achieve ultrafast growth:Path 1,fast edge attachment and ultrafast edge diffusion;Path 2,fast kink nucleation and ultrafast kink propagation.We perform kinetic Monte Carlo simulations and first-principles calculations to assess the viability of these two paths,finding that Path 1 is not viable due to the high edge diffusion barrier calculated from first-principles calculations.Remarkably,Path 2 reproduces all the experimental growth features(domain morphology,domain orientation,and growth rate),and the associated energetic data are consistent with first-principles calculations.The present work unveils the underlying mechanism for the ultrafast growth of WSe2,and may provide a new route for the ultrafast growth of other two-dimensional materials. | Shuai Chen Junfeng Gao Bharathi MSrinivasan Gang Zhang Viacheslav Sorkin Ramanarayan Hariharaputran Yong-Wei Zhang | 2019 | npj Computational Materials2019，，1： | 2 |
| 3 | Nimodipine: A review of its phammacodynamic and pharmacokinetic Properties and therapeutic potential in cerebrovascular disease 显示文摘 | Langley MS Sorkin EM | 1989 | Drugs1989，37，： | 2 |
| 4 | Captopril: An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure显示文摘 | Brogden Rex N Todd Peter A Sorkin Eugene M | 1988 | Drugs1988，36，5： | 1 |
| 5 | Optimized Scale-and-stretch for Image Resizing显示文摘 | Wang Yu-Shuen Tai Chiew-Lan Sorkine O | 2008 | ACM Transactions on Graphics2008，27，5： | 1 |
| 6 | Network of immune-neuroendocrine interactions显示文摘 | Besedovsky H Sorkin E | 1977 | Clin Exp Immunol1977，27，1： | 1 |
| 7 | Network of immune-neuroendocrine interactions显示文摘 | Besedovsky H Sorkin E | 1977 | Clin Exp Immunol1977，27，1： | 1 |
| 8 | Sleep-disordered breathing and insulin resistance in middle-aged and overweight men显示文摘 | Punjabi NM Sorkin JD Katzel LI | 2002 | Am J Respir Crit Care Med2002，165，5： | 1 |
| 9 | Efficacy of topically deliv- ered n~oxifloxacin against wound infection by Pseudomonas aerugi- nosa and methicillin-resistant Staphylococcus aureus 显示文摘 | Jacobsen F Fisahn C Sorkin M | 2011 | Antimicrob Agents Chemother2011，55，5： | 1 |
| 10 | Results of esophageal cancer surgical treatment in multiple primary neoplasma显示文摘 | Protsenko A Sorkin V Syromiatnikov A | 1998 | Anirurgila Mosk1998，12，： | 1 |
| 11 | Nicardipine显示文摘 | Sorkin EM Clissold SP | 1987 | Drugs1987，33，： | 1 |
| 12 | Carvedilol: a review of its pharmacodynamic and phar-macokinetic properties and therapeutic efficacy显示文摘 | Mc Tavish D Campoi-Richards D Sorkin EM | 1998 | Drugs1998，45，： | 1 |
| 13 | Network of immune-neuroendocrine interactions?显示文摘 | Besedovsky H Sorkin E | 1977 | Clin Exp Immunol1977，27，1： | 1 |
| 14 | Tramadol : a preliminary review of its pharmacodynamic and pharmacokinetic properties,and therapeu- tie potential in acute and chronic pain states显示文摘 | Lee CR McTavish D Sorkin EM | 1993 | Drugs1993，46，2： | 1 |
| 15 | The cadherin- catenin complex is expressed alternately with the adeno- matous polyposis coli protein during rat incisor ameloge- nesis显示文摘 | Sorkin BC Wang MY Dobeck JM | 2000 | J Histochem Cytochem2000，48，3： | 1 |
| 16 | An update of its therapeutic use in chemotherapy-induced mad postoperative nausea and vomiting 显示文摘 | Markham A Sorkin E M | 1993 | Drugs1993，45，6： | 1 |
| 17 | Role of the molecular absorbent recycling system(MARS)in the treatment of patients with acute exacerbation of chronic liver failure显示文摘 | Sorkine P Abraham R B Szold O | 2001 | Crit Care Med2001，29，7： | 1 |
| 18 | Tramadol : a preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic potentialin acute and chronic pain states显示文摘 | Lee CR McTavish D Sorkin EM | 1993 | Drugs1993，46，2： | 1 |
| 19 | Longitudinal changes in axial length in pseudophakie children显示文摘 | Sorkin IA Lambert SR | 1997 | J cataract Refract Surg1997，23，1： | 1 |
| 20 | Sotalol: a updated review of its pharmacological properties and therapeutic use in cardiac arrhythmias显示文摘 | Fitton A Sorkin EM | 1993 | Drugs1993，46，： | 1 |
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