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| 1 | 非洲裔美国人体力活动与高血压发生的相关性显示文摘非洲裔美国人在美国各种族(民族)中高血压患病率(男性为40.8%,女性为41.5%)最高。有证据表明,与美国其他种族(民族)相比,非洲裔美国人高血压与因心肌梗死、脑卒中和终末期肾脏疾病引起的过早功能丧失和死亡呈不成比例地升高相关。需要确定控制非洲裔美国人危险因素的措施,以减轻其发生高血压的风险。在许多其他人群中已证实,体力活动对预防高血压有保护作用。因此,高血压指南推荐采用体力活动作为预防性生活行为方式。 | Diaz KM Booth JN 3rd Seals SR Abdalla M Dubbert PM Sims M Ladapo JA Redmond N Muntner P Shimbo D | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Plasminogen kringle 5-engineered glioma cells block migration of tumor- associated macrophages and suppress tumor vascularization and progres- sion.显示文摘 | Perri SR Nalbantoglu J Annabi B Koty Z Lejeune L Francois M Di Falco MR Beliveau R Galipeau J | 2005 | 中国神经肿瘤杂志2005，3，3： | 8 |
| 3 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 4 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 5 | Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review显示文摘Human papillomavirus(HPV) has been implicated in the pathogenesis of a subset of oropharyngeal squamous cell carcinoma. As a result, traditional paradigms in relation to the management of head and neck squamous cell carcinoma have been changing. Research into HPVrelated oropharyngeal squamous cell carcinoma is rapidly expanding, however many molecular pathological and clinical aspects of the role of HPV remain uncertain and are the subject of ongoing investigation. A detailed search of the literature pertaining to HPV-related oropharyngeal squamous cell carcinoma was performed and information on the topic was gathered. In this article, we present an extensive review of the current literature on the role of HPV in oropharyngeal squamous cell carcinoma, particularly in relation to epidemiology, risk factors, carcinogenesis, biomarkers and clinicalimplications. HPV has been established as a causative agent in oropharyngeal squamous cell carcinoma and biologically active HPV can act as a prognosticator with better overall survival than HPV-negative tumours. A distinct group of younger patients with limited tobacco and alcohol exposure have emerged as characteristic of this HPV-related subset of squamous cell carcinoma of the head and neck. However, the exact molecular mechanisms of carcinogenesis are not completely understood and further studies are needed to assist development of optimal prevention and treatment modalities. | Robbie SR Woods Esther M O'Regan Susan Kennedy Cara Martin John J O'Leary Conrad Timon | 2014 | World Journal of Clinical Cases2014，2，6： | 5 |
| 6 | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells显示文摘 | Hsu, TL Hanson, SR Kishikawa, K Wang, SK Sawa, M Wong, CH | 2007 | 中国生物学文摘2007，21，10： | 5 |
| 7 | 新型低密度脂蛋白胆固醇评估对全球血脂异常指南中次级靶标非高密度脂蛋白胆固醇和载脂蛋白B应用的影响显示文摘血脂异常指南通常推荐非高密度脂蛋白胆固醇(non-high-density lipoprotein-cholesterol,non-HDL-C)和载脂蛋白B(apolipoprotein B,apoB)作为主要靶点低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)的次要靶点。 | Sathiyakumar V Park J Quispe R Elshazly MB Michos ED Banach M Toth PP Whelton SP Blumenthal RS Jones SR Martin SS 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 8 | Phytochemical constituents and antibacterial efficacy of the flowers of Peltophomm pterocarpum(DC.) Baker ex Heyne显示文摘Objective:To investigate the preliminary phytochemistry and antibacterial activity of the flower extract of Peltophorum pterocarpum.Methods:Phytochemical analysis was done by using the standard methods given by Harbone.The methanolic flower extract were tested against Escherichia coli,Klebsiella pneumonia,Pseudomonas aeruginosa.Staphylococcus aureus. Bacillus cereus,Salmonella typhi,Serratia marsecens,Acinetobacter baumannii.Enterobacter sp., Proteus mirabilis.Enterococcus faecalis and Streptococcus pyogenes by the agar disc diffusion method.Results:Preliminary phytochemical screening of flower extract showed the presence of phenolic compounds,flavonoids.saponins,steroids,tannins,xanthoproteic,carboxylic acids, coumarins and carbohydrates.The flower extract of Peltophorum pteroearpum showed significant activity against four gram positive(Staphylococcus aureus.Bacillus cereus.Enlerococcus faecalis and Streptococcus pyogenes) and three gram negative bacteria(Proteus mirabilis,Acinetohacter baumannii and Serratia marsecens).out of 12 pathogenic bacteria studied.Conclusion:The findings of the present study confirm the presence of significant antibacterial activity against human pathogens in the flowers of Peltophorum pleracarpum. | Sukumaran S Kiruba S Mahesh M Nisha SR Miller Paul Z Ben CP Jeeva S | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 9 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 10 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 11 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 12 | Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain显示文摘 | Hofer M Pagliusi SR Hohn A | 1990 | EM BO1990，9，： | 2 |
| 13 | Modeled microgravity disrupts collagen I/integrin signaling during osteoblastic differentiation of human mesenchymal stem cells显示文摘 | Meyers VE Zayzafoon M Gonda SR | | 0，，： | 2 |
| 14 | Synthesis and crystal structure of K4H2·18H2O显示文摘 | Ye SR Shan Y K He M Y | 2002 | Zeitschrift fur Kristallographie NCS2002，217，： | 2 |
| 15 | Role of osteopontin in cellular signaling and toxicant injury显示文摘 | DENHARDT DT GIACHELLI C M RITTLING SR | 2001 | Annu Rev Pharmacol Toxicol2001，41，： | 1 |
| 16 | Monosodium urate microcrystals induce cyclooxygerms-2 in human monocytes显示文摘 | Pouliot M James MJ McColl SR | 1998 | Blood1998，91，5： | 1 |
| 17 | Efficacy and safety of paliperidone extended-release tablets: results of a 6-week, randomized, placebo-controlled study 显示文摘 | Marder SR Kramer M Ford L | 2007 | Biol Psychiatry2007，62，12： | 1 |
| 18 | Delayed neurological deficits detected by an ischemic pattem in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage显示文摘 | Schulz M Kristeusen SR | 2004 | J Neurosurg2004，100，： | 1 |
| 19 | Ankle art hrodesis: long - term follow - up with gait analysis显示文摘 | Mazur J M Schuarle E Simon SR | 1979 | J Bone Joint Surg (Am)1979，61，： | 1 |
| 20 | SSRIs versusnon-SSRIs in posttraumatic stress disorder: an update with recommendations 显示文摘 | Asnis GM Kohn SR Henderson M | 2004 | Drugs2004，64，4： | 1 |
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