|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | New way to guide light 显示文摘 | J C Night P St Russell | 2002 | Science2002，296，： | 2 |
| 3 | Endlessly single-mode photonic crystal fiber显示文摘 | BIRKS T A KNIGHT J C RUSSELL P St J | 1997 | Opt Lett1997，22，96： | 1 |
| 4 | The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs 显示文摘 | Khan M A Herzog C A Peter J V St | 1998 | N Engl J Med1998，339，11： | 1 |
| 5 | Endlessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 6 | All si-lica single-mode optical fiber with photonic crystal cladding显示文摘 | Knight J C Birks T A Russell P St J | 1996 | Optics Letters1996，21，19： | 1 |
| 7 | All-silica single-mode optical fiber with photonic crystal cladding显示文摘 | KNIGHT J C BIRKS T A RUSSELL P St J | 1996 | Opt Lett1996，21，19： | 1 |
| 8 | Differential gene expression by Metarhizium anisopliae growing in root exudate and host(Manduca sexta)cuticle or hemolymph reveals mechanisms of physiological adaptation显示文摘 | Wang C S Hu G St Leger R J | 2005 | Fungal Genetics and Biology2005，42，： | 1 |
| 9 | All-silica single-mode optic fiber with photonic with photonic Crystal cladding显示文摘 | KNIGHT J C BIRKS T A RUSSELL P St J | 1996 | Opt Lett1996，21，15： | 1 |
| 10 | Endlessly single-mode photonic crystal fiber显示文摘 | BIRKS T A KNIGHT J C RUSSELL P St J | 1997 | Opt Lett1997，22，13： | 1 |
| 11 | Regulation of MMP- 9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases显示文摘 | St - Pierre Y Couillard J Van Themsche C | 2004 | Expert Opin Ther Targets2004，8，5： | 1 |
| 12 | Lipid peroxidation associated with accelerated aging of soybean axes 显示文摘 | ST E WERT R C BEWLEY J D | 1980 | Plant Physiology1980，65，3： | 1 |
| 13 | Decomposition of Finite Graphs into Forests显示文摘 | Nash-Williams C St J A | 1964 | Journal of London Mathematical Society1964，39，： | 1 |
| 14 | On Orientations, Connectivity and Odd Vertex Pairings in Finite Graphs显示文摘 | C St J A Nash-Wilhams | 1960 | Canad J Math1960，12，： | 1 |
| 15 | Analysis of Lipids from Cooked Beef by Thin-layerChromatography with Flame-ionization Detection显示文摘 | St Angelo A J James Jr C | 1993 | JAOCS1993，70，12： | 1 |
| 16 | Demonstration of ultra-flattened dispersion in photonic crystal fibers显示文摘 | Reeves W H Knight J C P St J Russell | 2002 | Optics Express2002，10，14： | 1 |
| 17 | All-sillica single-mode optical fiber with photonic crystal cladding 显示文摘 | Knight J C Briks T A Russel P St J | 1996 | Opt Lett1996，21，19： | 1 |
| 18 | Direct measurement of optical phase in the near field 显示文摘 | Knight J C Pottage J M Kakarantzas G Russell P St J | 2000 | Applied Physics Letters2000，76，5： | 1 |
| 19 | Serum levels of YKL-40 increases in patients with acute myocardial infarction显示文摘 | N(o)jgaard C H(o)st NB Christensen I J | 2008 | Coron Artery Dis2008，19，4： | 1 |
| 20 | Endlessly single-mode photonic crystal fiber显示文摘 | Birks T A Knight J C Russell P St J | 1997 | Opt Lett1997，22，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员