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| 1 | Combined goblet cell carcinoid and mucinous cystadenoma of the vermiform appendix显示文摘Goblet cell carcinoid is an uncommon primary tumor of the vermiform appendix, characterized by dual endocrine and glandular differentiation. Whether goblet cell carcinoid represents a morphological variant of appendiceal classical carcinoid or a mucin-producing adenocarcinoma is a matter of conjecture. Rare cases of goblet cell carcinoid with other concomitant appendiceal epithelial neoplasms have been documented. In this report, we describe a rare case of combined appendiceal goblet cell carcinoid and mucinous cystadenoma, and discuss the possible histopathogenesis of this combination. | Khaled O Alsaad Stefano Serra Runjan Chetty | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 2 | Helicobacter pylori eradication: Sequential therapy and Lactobacillus reuteri supplementation显示文摘AIM:To evaluate the role of sequential therapy and Lactobacillus reuteri (L. reuteri ) supplementation, in the eradication treatment of Helicobacter pylori (H. pylori ). METHODS:H. pylori infection was diagnosed in 90 adult dyspeptic patients. Patients were excluded if previously treated for H. pylori infection or if they were taking a proton pump inhibitor (PPI), H2-receptor antagonist or antibiotics. Patients were assigned to receive one of the following therapies:(1) 7-d triple therapy (PPI plus clarithromycin and amoxicillin or metronidazole) plus L. reuteri supplementation dur- ing antibiotic treatment; (2) 7-d triple therapy plus L. reuteri supplementation after antibiotic treatment; (3) sequential regimen (5-d PPI plus amoxicillin therapy followed by a 5-d PPI, clarithromycin and tinidazole) plus L. reuteri supplementation during antibiotic treatment; and (4) sequential regimen plus L. reuteri supplementation after antibiotic treatment. Successful eradication therapy was defined as a negative urea breath test at least 4 wk following treatment. RESULTS:Ninety adult dyspeptic patients were en- rolled, and 83 (30 male, 53 female; mean age 57 ± 13 years) completed the study. Nineteen patients were administered a 7-d triple treatment:11 with L. reuteri supplementation during and 8 after therapy. Sixty-four patients were administered a sequential regimen:32 with L. reuteri supplementation during and 32 after therapy. The eradication rate was significantly higher in the sequential group compared with the 7-d triple regimen (88% vs 63%, P = 0.01). No difference was found between two types of PPI. No difference in erad- ication rates was observed between patients submitted to L. reuteri supplementation during or after antibiotic treatment. Compliance with therapy was excellent in all patients. No difference in adverse effects was observed between the different antibiotic treatments and between patients submitted to L. reuteri supplementation during and after antibiotic treatment. There was a low incidence of adverse effects in all groups of patients with sequential therapy, probably due to the presence of the L. reuteri supplementation. CONCLUSION:The sequential treatment regimen achieved a significantly higher eradication rate of H. pylori compared with standard 7-d regimen. L. reuteri supplementation could reduce the frequency and the intensity of antibiotic-associated side-effects. | Cesare Efrati Giorgia Nicolini Claudio Cannaviello Nicole Piazza O'Sed Stefano Valabrega | 2012 | World Journal of Gastroenterology2012，18，43： | 4 |
| 3 | Porous silicon: a quantum sponge structure for silicon based optoelectronics显示文摘 | Ossicini Stefano Pavesi L | 2000 | Surface Science Reports2000，38，： | 1 |
| 4 | Mapping automotive process control on IEC/ISA FieldBus functionalities 显示文摘 | Cavalieri S Stefano A D Mirabella O | 1996 | Computers in Industry1996，28，3： | 1 |
| 5 | Early impairment of endo- thelial structure and function in young normal -weight women with polycystic ovary syndrome 显示文摘 | Francesco O Stefano P Teresa C | 2004 | J Clin Endocrinol Metab2004，89，9： | 1 |
| 6 | Mapping automotive process control on IEC/ISA field bus functionalities 显示文摘 | Caval S Stefano A D Mirabella O | 1996 | Computersin Industry1996，28，3： | 1 |
| 7 | Robust and efficient authentication of video stream broadcasting显示文摘 | GABRIELE O STEFANO C ROBERTO D P | 2011 | ACM Transactions on Information and System Security (TISSEC)2011，14，1： | 1 |
| 8 | Porous silicon : a quantum sponge structure for silicon based optoelectronics显示文摘 | Bisi O Stefano Ossicibi Pavesi L | 2000 | Surface Science Reports2000，38，： | 1 |
| 9 | Immunosuppression in the definitive and intermediate hosts of the human parasiteSchistosoma mansoni by release of immunoactive neuropeptides 显示文摘 | Duvaux-Miret O Stefano GB Smith EM | 1992 | ProcNatl Acad Sci USA1992，89，： | 1 |
| 10 | Short-term clinical outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventfieular dysfunction 显示文摘 | Stefano G Iacopo O Paolo C | 2000 | Circulation2000，101，24： | 1 |
| 11 | Porous Silicon: a Quantum Sponge Structure for Silicon Based Optoelectronics 显示文摘 | Bisi O Ossicini Stefano Pavesi L | 2000 | Su~ace Science Reports2000，38，： | 1 |
| 12 | Molecular phylogeny of the family Pectinidae (Mollusca: Bivalvia) based on mitochondrial 16S and 12S rRNA genes 显示文摘 | MARCO B ETTORE O STEFANO S | 2004 | Molecular Phylogenetics and Evolution2004，31，： | 1 |
| 13 | A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis显示文摘Several developmental stages of spermatogenesis are transcriptionally quiescent which presents major challenges associated with the regulation of gene expression. Here we identify that the zygotene to pachytene transit!on is not only associated with the resumption of transcription but also a wave of programmed mRNA degradation that is essential for meiotic progress!on. We explored whether terminal uridydyl transferase 4-(TUT4-) or TUT7-mediated 3' mRNA uridylation contributes to this wave of mRNA degradation during pachynema. Indeed, both TUT4 and TUT7 are expressed throughout most of spermatogenesis, however, loss of either TUT4 or TUT7 does not have any major impact upon spermatogenesis. Combined TUT4 and TUT7 (TUT4/7) deficiency results in embryonic growth defects, while conditional gene targeting revealed an essential role for TUT4/7 in pachytene progression. Loss of TUT4/7 results in the reduction of miRNA, piRNA and mRNA 31 uridylation. Although this reduction does not greatly alter miRNA or piRNA expression, TUT4/7-mediated uridylation is required for the clearanee of many zygotene-expressed transcripts in pachytene cells. We find that TUT4/7-regulated transcripts in pachytene spermatocytes are characterized by having long 3Z UTRs with length-adjusted enrichment for AU-rich elements. We also observed these features in TUT4/7-regulated maternal transcripts whose dosage was recently shown to be essential for sculpting a functional maternal transcriptome and meiosis. Therefore, mRNA 3Z uridylation is a critical determinant of both male and female germline transcriptomes. In conclusion, we have identified a novel requirement for 3' uridylation-programmed zygotene mRNA clearanee in pachytene spermatocytes that is essential for male meiotic progression. | Marcos Morgan Yuka Kabayama Christian Much Ivayla Ivanova Monica Di Giacomo Tatsiana Auchynnikava Jack Michael Monahan Dimitrios Michael Vitsios Lina Vasiliauskaite Stefano Comazzetto Juri Rappsilber Robin Campbell Allshire Bo Torben Porse Anton James Enright Donal O'Carroll | 2019 | Cell Research2019，29，3： | 1 |
| 14 | Mapping automotive process control on IEC/ ISA FieldBus functionalities 显示文摘 | Cavalieri S Stefano A D Mirabella O | 1996 | Computers in Industry1996，，28： | 1 |
| 15 | Bone marrow cells regenerate infarcted myocavdium 显示文摘 | Donald O Jan K Stefano C | 2001 | Nature2001，410，： | 1 |
| 16 | Cloning of Gaussian States by Linear Optics 显示文摘 | STEFANO O MATTEO G A | 2006 | Phys Rev A2006，73，06： | 1 |
| 17 | Mapping automotive process control on IEC/ISA FieldBus functionalities显示文摘 | Cavalieri S Stefano A Di Mirabella O | 1996 | Computers in Industry1996，28，： | 1 |
| 18 | Inflammatory disorders and atherosclerosis:new therapeutic approaches显示文摘 | Charakida M O Neil F Stefano Masi S | 2012 | Curr Pharmaceuti Design2012，17，37： | 1 |
| 19 | Ovarian size and blood flow in women with polycystic ovary syndrome and their correlations with endocrine parameters 显示文摘 | Enrico C Francesco O Stefano P | 2005 | Fertil Steril2005，84，2： | 1 |
| 20 | Bone marrow cells regenerate infracted myocardium显示文摘 | Donald O Jan K Stefano C | 2001 | Nature2001，410，： | 1 |
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