|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | The use of oil - in - water emulsions as a vehicle for parenteral drug administration显示文摘 | PRANKERD R J STELLA V J | 1990 | J Parenter Sci Technol1990，44，3： | 1 |
| 3 | Plasma homocysteine in early and late pregnancies complicatedwith preeclampsia and isolated intrauterine growth restriction显示文摘 | Anna R Baviera G Corrado F Ientile R Granese D Stella NC | 2004 | Acta Obstet Cynecol Scand2004，83，2： | 1 |
| 4 | Social and nonsocial factors in the childhood autism rating scale 显示文摘 | Stella J Mundy P Tuchman R | 1999 | Journal of Autism and Developmental Disorders1999，29，4： | 1 |
| 5 | Three-dimensional imaging for virtual assessment and treatment simulation in orthognathic sur- gery 显示文摘 | Caloss R Atkins K Stella J P | 2007 | Oral Maxillofac Surg Clin N Am2007，19，3： | 1 |
| 6 | Retrograde ileoscopy in chronic nonbloody diarrhea:a prospective,case-control study显示文摘 | Morini S Lorenzetti R Stella F | | 0，，07： | 1 |
| 7 | Safety and efficacy of drug-eluting balloons in percutaneous treatment of bifurcation lesions: the DEBIUT (drug-eluting balloon in bifurcation Utrecht) registry显示文摘 | FANGGIDAY J C STELLA P R GUYOMI S H | 2008 | Catheter Cardiovasc Interv2008，71，5： | 1 |
| 8 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 9 | Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas显示文摘 | Fornaro M Dell'Arciprete R Stella M | 1995 | Int J Cancer1995，62，5： | 1 |
| 10 | Analysis of PCR-based methods for characterization of Listeria monocytogenesstrains isolated from different sources显示文摘 | COCOLIN L STELLA S NAPPI R | 2005 | Int J Food Microbiol2005，1，： | 1 |
| 11 | Molecular simulation of adsorption natural gas显示文摘 | MATRANGA K R STELLA A MYERS A L | 1992 | Separation Science and Technology1992，27，14： | 1 |
| 12 | Effect of admini-stration of live Saccharomyces cerevisiae on milk produc-tion, milk composition, blood metabolites, and faecal florain early lactating dairy goats 显示文摘 | Stella A V Paratte R Valnegri L | 2007 | Small Ruminant Re-search2007，67，1： | 1 |
| 13 | Cost-effective- ness of Implantable Cardioverter Defibrillators in Brazil in the Public and Private Sectors显示文摘 | Ribeiro R A Stella S F Zimerman L I | 2010 | Arq Bras Cardiol2010，95，5： | 1 |
| 14 | Cloning of the gene encoding Trop-2 ,a cellsurface glycoprotein expressed by human carcinomas显示文摘 | Fornaro M Dell'Arciprete R Stella M Bucci C Nutini M Capri M | 1995 | Int J Cancer1995，62，： | 1 |
| 15 | Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin 显示文摘 | Stella S Bishoy R Christina JM | 2003 | Am J Pathol2003，163，： | 1 |
| 16 | Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin显示文摘 | Stella S Bishoy R Christina JM | 2003 | American Journal of Pathology2003，163，3： | 1 |
| 17 | Cyclodextrins: Their future in drug formulation and delivery 显示文摘 | Stella V J Rajewski R A | 1997 | Pharm Res1997，14，5： | 1 |
| 18 | Effect of administration of live Saccharomyces cerevisiae on milk production, milk composition, blood metabo- lites, and faecal flora in early lactating dairy goats 显示文摘 | Stella A V Paratte R Valnegri L | 2007 | Small Ruminant Research2007，67，1： | 1 |
| 19 | Cancers of unknown primary origin: current perspectives and future therapeutic strategies 显示文摘 | STELLA G M SENETTA R CASSENTI A | 2012 | J Transl Med2012，10，： | 1 |
| 20 | Release of testosterone from an osmotic pump tablet utilizing (SBE)7m - β - cyclodextrin as both a solubilizing and an osmotic pump agent 显示文摘 | Okimoto K Rajewski R A Stella V J | 1999 | J Control Release1999，58，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员