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| 1 | Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis显示文摘AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations(variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality(OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites(OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed. | Jonathan G Stine Puja M Shah Scott L Cornella Sean R Rudnick Marwan S Ghabril George J Stukenborg Patrick G Northup | 2015 | World Journal of Hepatology2015，7，27： | 42 |
| 2 | Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis显示文摘AIM To examine if liver transplant recipients with high-risk non-alcoholic steatohepatitis(NASH) are at increased risk for pre-transplant portal venous thrombosis.METHODS Data on all liver transplants in the United States from February 2002 through September 2014 were analyzed. Recipients were sorted into three distinct groups: High-risk(age > 60, body mass index > 30 kg/m2, hypertension and diabetes), low-risk and non-NASH cirrhosis. Multivariable logistic regression models were constructed.RESULTS Thirty-five thousand and seventy-two candidates underwent liver transplantation and of those organ recipients, 465 were transplanted for high-risk and 2775 for lowrisk NASH. Two thousand six hundred and twentysix(7.5%) recipients had pre-transplant portal vein thrombosis; 66(14.2%) of the high-risk NASH group had portal vein thrombosis vs 328(11.8%) of the lowrisk NASH group. In general, all NASH recipients were less likely to be male or African American and more likely to be obese. In adjusted multivariable regression analyses, high-risk recipients had the greatest risk ofpre-transplant portal vein thrombosis with OR = 2.11(95%CI: 1.60-2.76, P < 0.001) when referenced to the non-NASH group.CONCLUSION Liver transplant candidates with high-risk NASH are at the greatest risk for portal vein thrombosis development prior to transplantation. These candidates may benefit from interventions to decrease their likelihood of clot formation and resultant downstream hepatic decompensating events. Prospective study is needed. | Jonathan G Stine Curtis K Argo Shawn J Pelletier Daniel G Maluf Stephen H Caldwell Patrick G Northup | 2017 | World Journal of Hepatology2017，9，3： | 2 |
| 3 | No difference in portal and hepatic venous bacterial DNA in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt insertion显示文摘 | Christian Mortensen Stine Karlsen Henning Gr?nb?k Dennis T. Nielsen Susanne Frevert Jens O. Clemmesen S?ren M?ller J?rgen S. Jensen Flemming Bendtsen | 2013 | Liver Int2013，，9： | 2 |
| 4 | High levels of microRNA - 21 in the stroma of colorectal cancers predict short disease- free survival in stage II colon cancer patients显示文摘 | Boye Schnack Nielsen Stine J? rgensen Jacob Ulrik Fog | 2011 | Springer2011，28，： | 1 |
| 5 | The liver as a Target for chemical-chemicalinteractions显示文摘 | SAUER J M STINE E R GUNAWARHANA L | 1997 | Phamacol1997，，： | 1 |
| 6 | Diagnostic and therapeutic urologic procedures显示文摘 | Stine R J Avila J A Lemons M F | | 0，，03： | 1 |
| 7 | Proline accumulation in developing grapevine fruit occurs independently of changes in the levels of △'-pyrroline-5-carboxylate synthetase mRNA or protein显示文摘 | NAYLOR D J HOJ P B | 1999 | Plant Physiol1999，120，： | 1 |
| 8 | Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors:a Pe diatric Oncology Group phase Ⅱ study显示文摘 | Saylors RL 3rd Stine KC Sullivan J | 2001 | J Clin Oncol2001，19，15： | 1 |
| 9 | Approximating elementary functions with symmetric bipartite tables 显示文摘 | SCHULTE M J STINE J E | 1999 | IEEE Transactions on computers1999，48，8： | 1 |
| 10 | High-nitrogen energetic materials derived from azotetrazolate显示文摘 | Hiskey M Goldman N Stine J | 1998 | J of Energetic Materials1998，16，2： | 1 |
| 11 | Evaluation of the systemic acute phase response and endometrial gene expres- sion of serum amyloid A and pro- and anti-inflammatory cyto- kines in mares with experimentally induced endometritis显示文摘 | Mette C Dooleweerdt B C Stine J | 2010 | Vet Immunol Immunopathol2010，138，12： | 1 |
| 12 | Perirectal abscess显示文摘 | Marcus R H Stine R J Cohen M A | | 0，，： | 1 |
| 13 | High-nitrogen energetic materials derived from azotetrazolate显示文摘 | Hiskey M Goldman N Stine J | 1998 | J of Energetic Materials1998，16，： | 1 |
| 14 | Is N8 Cubane Stable显示文摘 | ENGELKE R STINE J R | | 0，，1089： | 1 |
| 15 | High-nitrogen energetic materials derived from azotetrazolate显示文摘 | Hiskey M Goldman N Stine J | 1998 | Energetic Materials1998，16，： | 1 |
| 16 | High-nitrogen energetic materials derived from azotetrazolate显示文摘 | Hiskey M Goldman N Stine J | 1998 | J Energetic Mater1998，16，23： | 1 |
| 17 | Assessment of evolution of pandemic Vibrio parahaemolyticus by multilocus sequence typing显示文摘 | Chowdhury N R Stine O C Morris J G | 2004 | J Clin Microbiol2004，42，： | 1 |
| 18 | Degradation of Terbutylazine ( 2-chloro4-ethylamino-6-terbutylamino-I, 3,5-triazine), Deisopropylatrazine ( 2-amino4 -chloro-6-ethylamino-1,3,5-triazine), and Chlorinated Dimethoxy Triazine ( 2 -Chloro4,6 - dimethoxy-1,3,5-triazine) by Zero Valent Iron and Electrochemical Reduction 显示文摘 | Dombek T Davis D Stine J | 2004 | Environ Pollut2004，129，2： | 1 |
| 19 | High-nitrogen energetic ma-terials deriver form azotetrazolate 显示文摘 | Hiskey M Goldman N Stine J | 1998 | J Energ Mater1998，16，2： | 1 |
| 20 | Methods for selective modifications of cyclodextrins 显示文摘 | Khan A R Forgo P Stine K J | 1998 | Chem Rev1998，98，5： | 1 |
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