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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | Reducing the effect of ground clutter on wind profiler velocity measurements显示文摘 | May P T R G Strauch | 1998 | J Atmos Oceanic Tech1998，15，： | 1 |
| 4 | Preliminary evaluation of the first NOAA demonstration network profiler显示文摘 | WEBER B L WUERTZ D B STRAUCH R G | 1990 | J Atmos Oceanic Technol1990，7，6： | 1 |
| 5 | Effects of precipitation on UHF wind profiler measurements显示文摘 | Wuertz D B B L Weber R G Strauch | 1988 | J Atmos Oceanic Tech1988，5，： | 1 |
| 6 | A dual-Doppler radar method for the determination of wind velocities within precipitating weather systems显示文摘 | Miller L J Strauch R G | 1974 | Remote Sense Environ1974，3，40： | 1 |
| 7 | The precision and relative accuracy of profiler wind measurements显示文摘 | STRAUCH R G WEBER B L FRISCH A S | 1987 | J Atmos Oceanic Technol1987，4，4： | 1 |
| 8 | The precision and relative accuracy of profiler wind measurements显示文摘 | Strauch R G B L Weber A S Frisch | 1987 | J Atmos Oceanic Tech1987，4，： | 1 |
| 9 | Effects of precipitation on UHF wind profiler measurements 显示文摘 | Wuertz D B Weber B L Strauch R G | 1988 | J Atmos Oceanic Technol1988，5，： | 1 |
| 10 | The Colorado wind profiling network显示文摘 | STRAUCH R G MERRITY D A MORAN K P | 1984 | J Atoms Oceanic Technol1984，1，1： | 1 |
| 11 | An alternative procedure for the 18O measurement of nitrate oxygen显示文摘 | BRUER K STRAUCH G | 2000 | Chem Geol2000，168，： | 1 |
| 12 | Formation and structural properties of salicylaldiminato complexes of zirconium and titanium显示文摘 | Strauch J Warren T H Erker G | 2000 | Inorganica Chimica Acta2000，，： | 1 |
| 13 | Urbane hydrogeologie-herausforderungen far forschung und praxis 显示文摘 | SCHIRMER M STRAUCH G REINSTORF F | 2007 | Grundwasser2007，12，3： | 1 |
| 14 | Atmospheric temperature measurement using Raman backscatter显示文摘 | Strauch R G Derr V E Cupp R E | 1971 | Appl Opt1971，10，12： | 1 |
| 15 | Preliminary evaluation of the ftrst NOAA demonstration network wind profile 显示文摘 | Weber B L Wuertz D B Strauch R G | 1990 | Journal of Atmospheric and Oceanic Technology1990，7，6： | 1 |
| 16 | The colorado wind-profiling network 显示文摘 | Strauch R G Merritt D A Moran K P | 1984 | Journal of Atmospheric and Oce- anic Technology1984，，1： | 1 |
| 17 | Indicators for assessing anthropogenic impact on urban surface and groundwater显示文摘 | STRAUCH G MODER M WENNRICH R | 2008 | Journal of Soils and Sediments2008，8，1： | 1 |
| 18 | Effects of precipitation on UHF wind profiler measurements 显示文摘 | Wuertz D B Weber B L Strauch R G | 1998 | Jomnal of Atmospheric and Oceanic Technology1998，5，3： | 1 |
| 19 | A dual-Doppler radar method for the determination of wind velocities within precipitating weather systems显示文摘 | Strauch R G | 1974 | Remote Sens Environ1974，3，4： | 1 |
| 20 | Formation of a butadienenickel-based zwitterionic singlecomponent catalyst for ethylene polymerization: an alternative activation pathway for homogeneous Ziegler-Natta catalysts of late transition metals显示文摘 | STRAUCH J W ERKER G KEHR G | 2002 | Angew Chem Int Ed2002，41，14： | 1 |
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