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| 1 | Migration of bone marrow progenitor cells in the adult brain of rats and rabbits显示文摘Neurogenesis takes place in the adult mammalian brain in three areas:Subgranular zone of the dentate gyrus(DG);subventricular zone of the lateral ventricle;olfactory bulb.Different molecular markers can be used to characterizethe cells involved in adult neurogenesis.It has been recently suggested that a population of bone marrow(BM)progenitor cells may migrate to the brain and differentiate into neuronal lineage.To explore this hypothesis,we injected recombinant SV40-derived vectors into the BM and followed the potential migration of the transduced cells.Long-term BM-directed gene transfer using recombinant SV40-derived vectors leads to expression of the genes delivered to the BM firstly in circulating cells,then after several months in mature neurons and microglial cells,and thus without central nervous system(CNS)lesion.Most of transgene-expressing cells expressed NeuN,a marker of mature neurons.Thus,BM-derived cells may function as progenitors of CNS cells in adult animals.The mechanism by which the cells from the BM come to be neurons remains to be determined.Although the observed gradual increase in transgene-expressing neurons over 16mo suggests that the pathway involved differentiation of BM-resident cells into neurons,cell fusion as the principal route cannot be totally ruled out.Additional studies using similar viral vectors showed that BM-derived progenitor cells migrating in the CNS express markers of neuronal precursors or immature neurons.Transgene-positive cells were found in the subgranular zone of the DG of the hippocampus 16 mo after intramarrow injection of the vector.In addition to cells expressing markers of mature neurons,transgene-positive cells were also positive for nestin and doublecortin,molecules expressed by developing neuronal cells.These cells were actively proliferating,as shown by short term BrdU incorporation studies.Inducing seizures by using kainic acid increased the number of BM progenitor cells transduced by SV40vectors migrating to the hippocampus,and these cells were seen at earlier time points in the DG.We show that the cell membrane chemokine receptor,CCR5,and its ligands,enhance CNS inflammation and seizure activity in a model of neuronal excitotoxicity.SV40-based gene delivery of RNAi targeting CCR5 to the BM results in downregulating CCR5 in circulating cells,suggesting that CCR5 plays an important role in regulating traffic of BM-derived cells into the CNS,both in the basal state and in response to injury.Furthermore,reduction in CCR5 expression incirculating cells provides profound neuroprotection from excitotoxic neuronal injury,reduces neuroinflammation,and increases neuronal regeneration following this type of insult.These results suggest that BM-derived,transgeneexpressing,cells can migrate to the brain and that they become neurons,at least in part,by differentiating into neuron precursors and subsequently developing into mature neurons. | Donnahue Dennie Jean-Pierre Louboutin David S Strayer | 2016 | World Journal of Stem Cells2016，8，4： | 9 |
| 2 | Analysis of the function of two circadian-regulated CONSTANS-LIKE genes显示文摘 | LEDGER S STRAYER C ASHTON F | 2001 | Plant J2001，26，1： | 1 |
| 3 | Performance characterization of video-shot-change detection methods 显示文摘 | Gargi U Kasturi R Strayer S H | 2000 | IEEE Transactions on Circuits and Systems for Video Technology2000，10，1： | 1 |
| 4 | Current status of gene therapy strategies to treat HIV/AIDS显示文摘 | STRAYER D S AKKINA R BUNNELL B A | 2005 | Mol Ther2005，11，6： | 1 |
| 5 | Pefformance characterization of video-shot-change detection Methods显示文摘 | Gargi U Kasturi R Strayer S H | 2000 | IEEE Transaction on Circuits and Systems for Video Technology2000，10，1： | 1 |
| 6 | Oxygen,organic matter,and sediment granulometry as controls on hyporheic animal communities显示文摘 | Strayer D L May S E Nielsen P | 1997 | Arch Hydrobiology1997，140，： | 1 |
| 7 | Current status of gene therapy strategies to treat HIV/AIDS显示文摘 | Strayer D S Akkina R Bunnell B A | 2005 | Mol Ther2005，11，6： | 1 |
| 8 | Initiation and reactivation of faults during movement over a thrust-fault ramp:numerical mechanical models显示文摘 | Eriekson S G Strayer L M Suppe J | 2001 | Journal of Structural Geology2001，23，： | 1 |
| 9 | Peffonnance charac- terization of video-shot-change detection methods显示文摘 | GARGI U KASTUR1 R STRAYER S H | 2000 | IEEE Cir- cuits and System for Video Technology2000，10，1： | 1 |
| 10 | Portable run-time support for dynamic object-oriented parallel processing 显示文摘 | Weissman J Strayer W T | 1996 | ACM Transactions on Computer Systems1996，14，2： | 1 |
| 11 | Loss of Nocturnin, a circadian deadenylase, confers re- sistance to hepatic steatosis and diet-induced obesity显示文摘 | Green C B Douris N Kojima S Strayer C A Fogerty J Lourim D | 2007 | Proe Natl Acad Sci USA2007，104，98： | 1 |
| 12 | Analysis of the function of two circadian-regulated CONSTANS LIKE genes显示文摘 | Ledger S Strayer C Ashton F | 2001 | The Plant Journal2001，26，： | 1 |
| 13 | Survival signaling in type Ⅱ pneumocytes activated by surfactant protein-A显示文摘 | WHITE M K STRAYER D S | 2002 | Exp Cell Res2002，280，2： | 1 |
| 14 | A child with severe relapsing Kawasaki disease rescued by IL-1 receptor blockade and extracorporeal membrane oxygenation显示文摘 | Cohen S Tacke CE Strayer B | | 0，，： | 1 |
| 15 | Performance Characterization of Video-Shot-Change Detection Methods 显示文摘 | U Gargi R Kasturi S H Strayer | 2000 | IEEE Transactions on Circuits and System for Video Technology2000，，1： | 1 |
| 16 | Driven to distraction:studies of driving and cellular phone use显示文摘 | Johnston W A Grison S | 1999 | Abs Psychonomic Soc1999，4，： | 1 |
| 17 | Performance characterization of video-shot-change detection methods显示文摘 | Gargi U Kasturi R Strayer S H | 2000 | IEEE Transactions on Circuits and Systems for Video Technology2000，10，1： | 1 |
| 18 | Using gene delivery to protect HIV-susceptible CNS cells: inhibiting HIV replication in microglia 显示文摘 | CORDELIER P STRAYER D S | 2006 | Virus Res2006，118，12： | 1 |
| 19 | Further evidence of intact working memory in autism显示文摘 | Ozonoff S Strayer D L | 2001 | Journal of Autism and Development Disorders2001，，27： | 1 |
| 20 | Ecology of freshwater shore zones 显示文摘 | Strayer D L Findlay S E | 2010 | Aquatic Science2010，72，： | 1 |
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