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| 1 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 2 | Effects of deletion and overexpression of the Autographa califomica nuclear polyhedrosis vires FP25K gene on synthesis of two occlusionderived virus envelope proteins and their transport into virusinduced intranuclear membranes显示文摘 | Rosas-Acosta G Braunagel S C & Summers M D | 2001 | J Virol2001，75，10： | 1 |
| 3 | Experimental investigation on the breakage of hard rock by the PDC cutters with combined action modes 显示文摘 | LI Xi -bing Summers D A Rupert G | 2001 | Tunnelling and Underground Space Technology2001，16，： | 1 |
| 4 | Investigation into the penetration and impact resistance of PDC cutters inclined at different attack angles显示文摘 | LI Xi - bing Summers D A Rupert G | 2001 | Transation of Nonferrous Metals Society of China2001，10，2： | 1 |
| 5 | Production of human beta interferon in insect cells infected with a baculovirus expression vector显示文摘 | SMITH G E SUMMERS M D FRASER M J | 1983 | Mol Cell Bio1983，3，12： | 1 |
| 6 | I Production of human beta interferon in insect cells infected with a baculovirus expression vector显示文摘 | Smith G E Summers M D Fraser M | 1983 | Mol Cell Biol1983，3，： | 1 |
| 7 | Recombinant protein secretion in Escherichia coli 显示文摘 | Mergulhao F J Summers D K Monteiro G A | 2005 | Biotechnology Advances2005，23，： | 1 |
| 8 | Production of human beta interferon in insect cells infected with baculovirus expression vector显示文摘 | Smith G E Summers M D Fraser M J | 1983 | Mol Cell Biol1983，3，12： | 1 |
| 9 | A manual of methods for baculovirus vectors and insect cell culture procedures 显示文摘 | Summers M D Smith G E | 1987 | Taxas Agriculture Experiment Station Bulletin1987，155，5： | 1 |
| 10 | Acquisition of host cell DNA sequences by baculoviruses : relationship between host DNA in- sertions and FP mutants of Autographa californica and Galleria mel- lonella nuclear polyhedresis viruses显示文摘 | Fraser M J Smith G E Summers M D | 1983 | J Virol1983，47，2： | 1 |
| 11 | Production of human beta interferon in insect cell infected with baculovirus expression vec- tor显示文摘 | Smith G E Summers M D Fraser M J | 1983 | J Mol Cell Biol1983，3，： | 1 |
| 12 | A protocol to formalise function verbs to support conservation based model checking显示文摘 | Sen C Summers J D Mocko G M | 2011 | Journal of Engineering Design2011，22，1112： | 1 |
| 13 | A new paradigm in large scale assembly-research priori- ties in measurement assisted assembly显示文摘 | MAROPOUI OS P G MUELANER J E SUMMERS M D | 2014 | International Jour- nal of Advanced Manufacturing Technology2014，70，14： | 1 |
| 14 | Polydnavirus DNA is integrated in the DNA of its parasitoid wasp host显示文摘 | FLEMING J A G SUMMERS M D | 1991 | Proceedings of the National Academy of Sciencesof USA1991，88，： | 1 |
| 15 | Anslysis of impact hammer rebound to estimate rock drillability 显示文摘 | Li X Rupert G Summers D A | 2000 | Rock Mechanics and Rock Engineering2000，33，1： | 1 |
| 16 | Recombinant pro- tein secretion in Escherichia coli显示文摘 | Mergulhao F J M Summers D K Monteiro G A | 2005 | Biotechnol Adv2005，23，： | 1 |
| 17 | Molecular engineering of the Autographa californica nuclear polyhedrosis virus ge- nome:Deletion mutations within the polyhedrin gene 显示文摘 | Smith G E Fraser M J Summers M D | 1983 | J Virol1983，46，： | 1 |
| 18 | Molecular engineering of the AcNPV genome deletion mutations within the polyhedrin gene显示文摘 | Smith G E Fraser M J Summers M D | 1983 | J Virol1983，46，： | 1 |
| 19 | Did Henry Ford Pay Efficiency Wages显示文摘 | Raft D M G Summers L H | 1987 | Journal of Labor Economics1987，，4： | 1 |
| 20 | Experimental investigation on the breakage of hard rock by the PDC cutters with combined action modes显示文摘 | LI X B SUMMERS D A RUPERT G | 2001 | Tunneling and Underground Space Technology2001，16，2： | 1 |
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