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| 1 | Anti-microbial principles of selected remedial plants from Southern India显示文摘Objective:To examine the anti-bacterial activity of leaf extracts of Morus alba L.(Moraceae)and Piper betel L.(Piperaceae),and seed extracts of Bombax ceiba L.(Borabacaceae).Methods:We have partially purified plant extracts by solvent extraction method,and evaluated the effect of individual fractions on bacterial growth using Escherichia coli(E.coli),Pseudomonas aeruginosa(P.aeruginosa) and Staphylococcus aureus(S.aureus) bacterial strains.Results:Compared with Morus and Bombax fractions,Piper fractions showed significant growth inhibition on all the three types of bacteria studied.The EtOAc-hexane fractions of Piper leaves exhibited significant antibacterial activity with minimum inhibitory concentrations(MIC) of 50 μg/mL culture against both gram-positive and gram-negative bacteria.The EtOAc-fractions Ⅰ,Ⅱ,and Ⅳ inhibited bacterial colony formation on soft agar in addition to growth inhibition.A combination treatment of piper fractions with ampicillin resulted in significant growth inhibition in E.coli and P.aeruginosa,and combination with anticancer drug geldanamycin(2 μg/mL) showed selective growth inhibition against P.aeruginosa and S.aureus.Three major compounds,i.e.,eugenol,3-hexene-ol and stigmasterol,were primarily identified from Piper betel leaf extractions.Among the individual compounds,eugenol treatment showed improved growth inhibition compared with stigmasterol and 3-hexene-ol.Conclusions:We are reporting potential anti-bacterial compounds from Piper betel against both gram-positive and gram-negative bacteria either alone or in combination with drug treatment. | Tirupathi Rao G Suresh Babu K J Ujwal Kumar Sujana P A Veerabhadr Raoa Sreedhar AS | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 5 |
| 2 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 3 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study显示文摘 | Timothy J Price Marc Peeters Tae Won Kim Jin Li Stefano Cascinu Paul Ruff Atilli Satya Suresh Anne Thomas Sergei Tjulandin Kathy Zhang Swaminathan Murugappan Roger Sidhu | 2014 | Lancet Oncology2014，，6： | 2 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 6 | Soapstock and deodorizer distillates from north American vegetable oils:review on their characterization, extraction and utilization 显示文摘 | MARIE J D SURESH S N | 2007 | Food Research International2007，40，8： | 1 |
| 7 | Justification techniques for advanced manufacturing technologies 显示文摘 | Meredith J Suresh N | 1986 | International Journal of Production Research1986，24，5： | 1 |
| 8 | Regulation of telomerase during human placental differentiation:a role for TGF-β1显示文摘 | Rama S Suresh Y Rao A J | 2001 | Mol Cell Endocrinol2001，182，： | 1 |
| 9 | Tensile fracture toughness of ceramic materials: effects of dynamic loading and elevated temperatures显示文摘 | Suresh S Nakamura T Yeshurun Y Yang KH Duffy J | 1990 | Journal of the American Ceramic Society1990，73，8： | 1 |
| 10 | Assessing sex assignmentconcordance with genotype and phenotype 显示文摘 | Suresh D Crawford J Axelrad ME | 2013 | Int J Pediatr En-docrinol2013，2013，1： | 1 |
| 11 | Competitive enzyme-linked immunosorbent assay based on monoclonal antibody and recombinant hemagglutinin for serosurveillance of rinderpest virus 显示文摘 | Renukaradhya G J Suresh K B Rajasekhar M | 2003 | J Clin Microbiol2003，41，3： | 1 |
| 12 | The impact of pricing policy on sales variability in a supermarket retail context 显示文摘 | Hamister J W Suresh N C | 2008 | International Journal of Production Economics2008，111，2： | 1 |
| 13 | Sphericalindentation of compositionally graded material: Theoryand experiment 显示文摘 | Suresh S Giannakopoulos A E Alcala J | 1997 | Acta Materialia1997，45，： | 1 |
| 14 | Spectroscopy and near infrared upconversion of Er3+-doped TZNT glasses显示文摘 | VenkataKrishnaiah K Marques-Hueso J Suresh K | 2016 | Journal of Lumi- nescence2016，169，： | 1 |
| 15 | Validation of a sensitive LC-MS assay for quantification of glyburide and its metabolite 4-Wanshydroxy glyburide in plasma and urine: an OPRU Network study original research article显示文摘 | SURESH B N BRIAN J K MARY F H | 2007 | Journal of Chromatography B2007，860，1： | 1 |
| 16 | Synthesis and biological evaluation of 415-sulphonamido and 4~- podophyllotoxins as DNA topoisomerase-IIct and apoptosis inducing agents 显示文摘 | KAMAL A SURESH P RAMAIAH M J | 2012 | Bioorg Med Chem2012，20，： | 1 |
| 17 | Regulation of telomerase during human placental differentiation:a role for TGFbetal显示文摘 | Rama S Suresh Y Rao A J | 2001 | Mol Cell Endoerinol2001，182，2： | 1 |
| 18 | Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria显示文摘 | Suresh S Spatz J Mills J P | 2005 | Acta Biomater2005，，1： | 1 |
| 19 | Quantitative prediction of oral absorption of PEPT1 substrates based on in vitro uptake into Caco-2 cells显示文摘 | Suresh K Ritesh J Deep K | 2008 | Int J Pharm2008，354，12： | 1 |
| 20 | Effect of Feeding Yeast Culture (Saccharomyces Cerevisae) and Lactobacillus Acidophilus on Production Performance of Crossbred Dairy Cows显示文摘 | KOMARI R K R EDDY Y K L SURESH J | 1999 | J Dairy Sci1999，82，1： | 1 |
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