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| 1 | 改进医疗服务质量、确保病人安全的教学方法显示文摘提高医疗服务质量、确保病人安全是当前医学教育及培训面临的巨大挑战。今天的医生及医务工作者应具备良好的沟通能力,掌握如何在临床实践中鉴别、预防和处理不良事件及接近过失事件(nearmisses),如何使用当前获得的证据及相关信息,如何安全有效地在团队中工作,如何在实践中教授和学习病人安全知识,如何根据认可的伦理原则服务公众。 | Merrilyn M Walton Bruce H Barraclough Samantha A Van Staalduinen Susan L Elliott 段玉蓉(译) 张鸣明(审校) | 2009 | 中国循证医学杂志2009，9，9： | 7 |
| 2 | Mental and physical symptoms associated with lower social support for patients with hepatitis C显示文摘AIM: To systematically examine the impact of the hepatitis C virus (HCV) diagnosis on patients' level of social support in a large-scale study. METHODS: Patients evaluated and treated for HCV in a tertiary referral center were enrolled in a cross-sectional study. Demographic data, functional and emotional status as measured by the Hospital Anxiety and Depression Scale (HAD) and the Sickness Impact Profile (SIP), severity of liver disease, mode of acquisition, and physical and psychiatric comorbidities were collected from patients or abstracted from the medical record. All participants completed a semi-structured interview, addressing questions of social support. RESULTS: A total of 342 patients (mean age 45.2 years; 37% women) were enrolled. Ninety-two (27%) patients described lower levels of support by family and friends. Nearly half of the participants (45%) noted the loss of at least one relationship due to the disease. Fears related to transmitting the disease (25%) were common and often associated with ignorance or even discrimination by others (19%). Nearly one fifth of the patients did not share information about their disease with others to avoid being stigmatized. Lower levels of social support were significantly associated with living alone, being unemployed, being excluded from antiviral therapy, having psychiatric comorbidities, contracting HCV through intravenous drug use, having high levels of anxiety and depression as measured by the HAD and negative mood state as measured by the SIP. Patients reporting lower levels of social support also noted more physical symptoms as measured by the SIP. CONCLUSION: Patients with hepatitis C often face significant social problems, ranging from social isolation to familial stress. The most common concerns reflect a limited insight of patients and their relatives and friends about the disease, the risk factors for its spread, and about potential consequences. Our data suggest that educational interventions targeting support persons and the stressors identified in our findings may lessen or alleviate the social strains patients with hepatitis C experience. | Julie A Blasiole Laura Shinkunas Douglas R LaBrecque Robert M Arnold Susan L Zickmund | 2006 | World Journal of Gastroenterology2006，12，29： | 5 |
| 3 | Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery显示文摘AIM: To investigate the impact of minor abdominal surgery on the caecal microbial population and on markers of gut inflammation.METHODS: Four week old piglets were randomly allocated to a no-surgery 'control' group(n = 6) or a 'transection surgery' group(n = 5).During the transection surgery procedure, a conventional midline incision of the lower abdominal wall was made and the small intestine was transected at a site 225 cm proximal to the ileocaecal valve, a 2 cm segment was removed and the intestine was re-anastomosed.Piglets received a polymeric infant formula diet throughout the study period and were sacrificed at two weeks post-surgery.Clinical outcomes including weight, stool consistency and presence of stool fat globules were monitored.High throughput DNA sequencing of colonic content was used to detect surgery-relateddisturbances in microbial composition at phylum, family and genus level.Diversity and richness estimates were calculated for the control and minor surgery groups.As disturbances in the gut microbial community are linked to inflammation we compared the gene expression of key inflammatory cytokines(TNF, IL1 B, IL18, IL12, IL8, IL6 and IL10) in ileum, terminal ileum and colon mucosal extracts obtained from control and abdominal surgery groups at two weeks post-surgery.RESULTS: Changes in the relative abundance of bacterial species at family and genus level were confined to bacterial members of the Proteobacteria and Bacteroidetes phyla.Family level compositional shifts included a reduction in the relative abundance of Enterobacteriaceae(22.95 ± 5.27 vs 2.07 ± 0.72, P < 0.01), Bacteroidaceae(2.54 ± 0.56 vs 0.86 ± 0.43, P < 0.05) and Rhodospirillaceae(0.40 ± 0.14 vs 0.00 ± 0.00, P < 0.05) following transection surgery.Similarly, at the genus level, changes associated with transection surgery were restricted to members of the Proteobacteria and Bacteroidetes phyla and included decreased relative abundance of Enterobacteriaceae(29.20 ± 6.74 vs 2.88 ± 1.08, P < 0.01), Alistipes(4.82 ± 1.73 vs 0.18 ± 0.13, P < 0.05) and Thalassospira(0.53 ± 0.19 vs 0.00 ± 0.00, P < 0.05).Surgeryassociated microbial dysbiosis was accompanied by increased gene expression of markers of inflammation.Within the ileum IL6 expression was decreased(4.46 ± 1.60 vs 0.24 ± 0.06, P < 0.05) following transection surgery.In the terminal ileum, gene expression of TNF was decreased(1.51 ± 0.13 vs 0.80 ± 0.16, P < 0.01) and IL18(1.21 ± 0.18 vs 2.13 ± 0.24, P < 0.01), IL12(1.04 ± 0.16 vs 1.82 ± 0.32, P < 0.05) and IL10(1.04 ± 0.06 vs 1.43 ± 0.09, P < 0.01) gene expression increased following transection surgery.Within the colon, IL12(0.72 ± 0.13 vs 1.78 ± 0.28, P < 0.01) and IL10(0.98 ± 0.02 vs 1.95 ± 0.14, P < 0.01) gene expression were increased following transection surgery.CONCLUSION: This study suggests that minor abdominal surgery in infants, results in long-term alteration of the colonic microbial composition and persistent gastrointestinal inflammation. | Susan Lapthorne Julie E Bines Fiona Fouhy Nicole L Dellios Guineva Wilson Sarah L Thomas Michelle Scurr Catherine Stanton Paul D Cotter Prue M Pereira-Fantini | 2015 | World Journal of Gastroenterology2015，21，14： | 3 |
| 4 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 5 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 6 | The Impact of E-commerce on Supply Chain Relationships 显示文摘 | Susan L Golicic Donna F Davis Teresa M McCar-thy John T Mentzer | 2002 | International Journal of Physical Distribution & Logistics Management2002，32，910： | 1 |
| 7 | Thirteen week feeding study withtransgenic maize grain containing event DAS-157-1 in Sprague-Dawley rats显示文摘 | Susan A M Ian L Jean S | 2007 | Food and Chemical Toxicology2007，45，4： | 1 |
| 8 | Augmentation of pedicle screw fixation strength using an injectable calcium phosphate cement as a function of injection timing and method 显示文摘 | Susan M RennerMS Tae-Hong L | 2004 | Spine2004，11，： | 1 |
| 9 | What is IgG4? A review of the biology of a unique immunoglobulin subtype显示文摘 | Ajay Nirula Scott M Glaser Susan L Kalled Frederick R Taylora | 2011 | Current Opinion in Rheumatology2011，，1： | 1 |
| 10 | Choice of methodology for assessing genetic impacts of environmental stressors:Polymorphism and reproducibility of RAPD and AFLP fingerprints显示文摘 | Mark J B Susan L A Bernie M 2001 | 2001 | Ecotoxicology2001，10，： | 1 |
| 11 | The Surgical Anatomy of Lumbar Medial Branch Neurotomy(Facet Denervation)显示文摘 | Peter L Susan M Jayantilal G | 2004 | Pain Medicine2004，5，： | 1 |
| 12 | An improved colorimetric assay for the measurement of transglutaminase (type Ⅱ) ε- (γ-glutamyl) 1 ysinecross-linking activity显示文摘 | Susan M Trigwell Paul T L Alan J Hargreaves | 2004 | Anal Bioehem2004，330，： | 1 |
| 13 | An analysis of manufacturer-retailer supply chain coordination in cooper- ative advertising 显示文摘 | Huang Z M Susan X L | 2000 | Decision Sciences2000，33，3： | 1 |
| 14 | LCGC显示文摘 | Robert Steffeck J Susan Woo L Raymond Weigand J James Anderson M | 1995 | 13 : 7201995，13，： | 1 |
| 15 | Evaluating alterations of genetic diversity in sunfish populations exposed to contaminants using RAPD assay显示文摘 | Lee K L Adams S M | 1998 | Aquatic Toxicology1998，43，： | 1 |
| 16 | Structural equation modeling and its relationship to multiple regression and factor analysis显示文摘 | Carol M Msil Susan L | 1998 | Research in Nursing & Health1998，，： | 1 |
| 17 | Improvement in the solution stability of porcine somatotropin by chemical modification of cysteine residues 显示文摘 | Brian L Buckwalter Susan M Cady Hong-Ming Shieh | 1992 | J Agric Food Chem1992，40，： | 1 |
| 18 | Fluoxetine: a review ofits therapeutic potential in the treatment of depressionassociated with physical illness显示文摘 | Susan M Cheer Karen L Goa | 2001 | Drugs2001，61，1： | 1 |
| 19 | Predicting progeny variance from parental divergence in hard spring wheat 显示文摘 | Rebecca L B Susan P L Roy J M | 1998 | Crop Science1998，38，： | 1 |
| 20 | Monitoring pressure ulcer heal-ing in persons with disabilities 显示文摘 | Marla M Susans T Maria L | 2005 | Rehabil Nurs2005，30，3： | 1 |
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