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| 1 | Expression and Chromosomal Mapping of Mouse Gpx2 Gene Encoding the Gastrointestinal Form of Glutathione Peroxidase, GPX-GI显示文摘GPX-GI is a cytosolic tetrameric Se-dependent glutathione peroxidase, similar in properties to GPX-1. Unlike the almost ubiquitous GPX-1, GPX-GI is mainly expressed in the epithelium of gastrointestinal tract. GPX-GI contributes to at least fifty percent of GPX activity in rodent small intestmal epithelium. The total GPX activity consists of at least 70% of selenium-dependent GPX activity in this compartment.By analyzing a panel of mouse mterspecies DNA from the Jackson Laboratory’s backcross resource,we mapped Gpx2 gene to mouse chromosome 12 between D12Mit4 and D12Mit5, near the Ccs1 locus which contains a colon cancer susceptibility gene. A pseudogene, Gpx2-ps is mapped to mouse chromosome 7.Comparison of Gpx2 gene expression in three pairs of C57BL/6Ha and ICR/Ha mice which are respectively resistant and sensitive to dimethylhydrazine-induced colon cancer, we found a higher Gpx2 mRNA level in C57BL/6Ha colon than ICR/Ha colon. Interestingly, a lower level of GPX activity is found in the resistant strain of mice. Because GPX-1 has three times higher specific activity than GPX GI, our data suggest that the decreased GPX activity may result from a higher level of Gpx2 gene expression in those cells co-express GPx1 | FONG-FONG CHU R. STEVEN ESWORTHY YE SHIH HO MARGIT BERMEISTER KRISTINE SWIDEREK AND ROSEMARY W. ELLIOTT(Department of Medical Oncology, City of Hope Midical Center, Duarte,CA91010, USA Department of Psychiatry and Human Genetics,Mintal Health Research | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 2 | Gallinacins: cysteinerich antimicrobial peptides of chicken leukocytes 显示文摘 | HARWIG S S SWIDEREK K M KOKRYAKOV V N | 1994 | FEBS Lett1994，342，3： | 1 |
| 3 | Prospective study to de- termine the volume of pleural fluid required to diagnose malignancy 显示文摘 | Swiderek J Morcos S Donthireddy V | 2010 | Chest2010，137，1： | 1 |
| 4 | Gallinacin-1: eysteine-rieh antimierobial peptides of chicken leuko eytes显示文摘 | Harwig S S Swiderek K M Kokryakov V N | 1994 | FEBSLett1994，342，： | 1 |
| 5 | Abnormalities in platelet membrane structure and function in Alzheimer′s disease and ischemic stroke显示文摘 | Swiderek W Kozubski C | 1997 | Platelet1997，8，： | 1 |
| 6 | Gallinacin-1: cysteine-rich antimicrobial peptides of chicken leukocytes显示文摘 | HARWIG S S SWIDEREK M KOKRYAKOV V N | 1994 | FEBS Lett1994，342，： | 1 |
| 7 | Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes 显示文摘 | Harwig S S Swiderek K M Kokryakov V N | 1994 | FEBS Lett1994，342，3： | 1 |
| 8 | Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes 显示文摘 | Harwig S S L Swiderek K M Kokryakov V N | 1994 | FEBS Lett1994，342，3： | 1 |
| 9 | Abnormalities in platelet membrane structure and function in Alzheimer's disease and ischaemic stroke显示文摘 | | 1997 | Platelet1997，8，2： | 1 |
| 10 | Prospective Study To Determine the Volume of Pleural Fluid Required To Diagnose Malignancy 显示文摘 | Jennifer Swiderek | 2010 | CHEST2010，137，1： | 1 |
| 11 | Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes 显示文摘 | Swiderek K M Kokryakov V N | 1994 | FEBS Lett1994，342，： | 1 |
| 12 | Galli- naeins:cysteine-rieh antimicrobial peptides of chicken leukoeytes 显示文摘 | Harwig SS Swiderek KM Kokryakov VN | 1994 | FEBS Lett1994，342，3： | 1 |
| 13 | Thrombospondin - 1 re- ceptor mediates autophagy of RAS - expressing cancer cells and trig- gers tumour growth inhibition 显示文摘 | Kalas W Swiderek E Switalska M | 2013 | Anticaneer Research2013，33，4： | 1 |
| 14 | Prospective study to determine the volume of pleural fluid required to diagnose malignancy显示文摘 | Swiderek J Morcos S Donthireddy V | 2010 | Chest2010，137，1： | 1 |
| 15 | Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes 显示文摘 | Harwig S S Swiderek K M Kokryakov V N et a1 | 1994 | FEBS Lett1994，342，3： | 1 |
| 16 | Prospective study to determine the volume of pleural fluid required to diagnose malignancy显示文摘 | Swiderek J Morcos S Donthireddy V | 2010 | Chest2010，137，1： | 1 |
| 17 | Prospectivestudy to determine the volume of pleural fluid required to diagnose malignancy显示文摘 | Swiderek J Morcos S Donthireddy V | 2010 | Chest2010，137，1： | 1 |
| 18 | Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo显示文摘 | Moldt B Rakasz E G Schultz N Chan-Hui P Y Swiderek K Weisgrau K L Piaskowski S M Bergman Z Watkins D I Poignard P Burton D R | 2012 | Proc Natl Acad Sci USA2012，109，18： | 1 |
| 19 | Abnormalities in platelet membrane structure and fuction in Alzheimer's disease and ischemic strokd显示文摘 | Swiderek W Kozubski C | 1997 | Platelet1997，8，： | 1 |
| 20 | Gallinacins:cysteine-rich antimicrobial peptides of chicken leukocytes显示文摘 | Harwig S S Swiderek K M Kokryakov V N | 1994 | FEBS Lett1994，342，3： | 1 |
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