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| 1 | 20~64岁人群的抗抑郁药使用和心血管结局风险:初级医疗数据库的队列研究显示文摘目的探讨抑郁患者不同抗抑郁治疗方案与3种心血管结局(心肌梗死、中风或短暂性脑缺血发作、心律不齐)比率的关系。设计队列研究。场所为 QResearch 初级医疗数据库贡献数据的英国全科诊所。参与者2000-01-01至2011-07-31首次诊断为抑郁症的年龄为20~64岁的238963例患者。干预抗抑郁药(三环类及相关抗抑郁药、选择性5-羟色胺再摄取抑制剂、其他抗抑郁药)、剂量、使用时间、个体化抗抑郁药。主要结局指标5年随访过程中心肌梗死、中风或短暂性脑缺血发作、心律不齐的首次确诊。采用 Cox 比例风险回归模型估计风险比例,调整潜在混杂变量。结果5年随访期间,772例患者发生心肌梗死,1106例患者发生中风或短暂性脑缺血发作,1452例患者发生心律不齐。未发现抗抑郁药与心肌梗死存在显著关联。随访第1年,使用选择性5-羟色胺再摄取抑制剂患者与未使用选择性5-羟色胺再摄取抑制剂患者相比,心肌梗死风险明显下降〔 HR'=0.58,95% CI (0.42,0.79)〕;在个体化抗抑郁药中,氟西汀能够大幅降低心肌梗死风险〔HR'=0.44,95% CI(0.27,0.72)〕,而洛非帕明则会大幅增加心肌梗死风险〔HR'=3.07,95% CI(1.50,6.26)〕。抗抑郁药或个体化抗抑郁药与中风或短暂性脑缺血发作风险无明显关联。5年随访期间,抗抑郁药与心律失常无明显关联,但是在三环类及相关抗抑郁药治疗期间的前28 d 风险大幅上升〔HR'=1.99,95% CI(1.27,3.13)〕。5年随访期间,氟西汀大幅降低心律不齐的风险〔HR'=0.74,95% CI(0.59,0.92)〕,但是,即使采用高剂量,西酞普兰与心律不齐风险仍无明显关联〔 HR'=1.11,95% CI(0.72,1.71),剂量≥40 mg/ d)。结论选择性5-羟色胺再摄取抑制剂不会增加20~64岁抑郁患者的心律不齐或中风或短暂性脑缺血发作风险,而西酞普兰也不会增加心律不齐风险。选择性5-羟色胺再摄取抑制剂可能会降低心肌梗死风险,尤其是氟西汀,而洛非帕明会增加心肌梗死风险。 | Coupland C Hill T Morriss R 本刊编辑部 | 2016 | 中国全科医学2016，19，15： | 7 |
| 2 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | Electrically pumped metallic and plasmonic nanolasers显示文摘In recent years, there have been a significant number of demonstrations of small metallic and plasmonic lasers. The vast majority of these demonstrations have been for optically pumped devices. Electrically pumped devices are advantageous for applications and could demonstrate concepts not amenable for optical pumping. However, there have been relatively few demonstrations of electrically pumped small metal cavity lasers. This lack of results is due to the following reasons: there are limited types of electrically pumped gain media available; there is a significantly greater level of complexity required in the fabrication of electrically pumped devices; finally, the required components for electrical pumping restrict cavity design options and furthermore make it intrinsically more difficult to achieve lasing. This review looks at the motivation for electrically pumped nanolasers, the key issues that need addressing for them to be realized, the results that have been achieved so far including devices where lasing has not been achieved, and potential new directions that could be pursued. | Martin T Hill | 2018 | Chinese Physics B2018，27，11： | 3 |
| 5 | 有源相控阵——现状与展望显示文摘作者回顾了用相控阵可获得的各种性能并仔细定义了有源相控阵。他描述了混合式与单片式的模块构造方法以及主要的射频功率器件 (双极型晶体管与场效应管)。为了有源相控阵列的使用,作者对损耗降低、可靠性、成本以及其他性能得益等常见问题作了叙述,指出按工程观点来看降低损耗是最重要的。在对技术现状进行简短回顾后,作者建议雷达工程师应当在技术方面进行更多的工作,并且建议大家应对目前系统级开发 (象英国Plessey的MESAR) 进行研究。 | Hill Robert T 高艳明 应启珩 | 1990 | 现代雷达1990，12，1： | 2 |
| 6 | Polyoxometalates in medicine显示文摘 | Rhule J T Hill C L Judd D A | | 0，，： | 2 |
| 7 | 气缸孔粗糙度对机油耗影响的试验研究显示文摘侧重于内燃机机油耗控制中的一个重要因素。以前的研究工作已经通过理论或试验方法建立了气缸孔粗糙度与机油耗之间的关系。在本研究中,利用回归分析和新的瞬态放射性示踪剂机油耗测量法所得到的试验数据用统计学方法推导出了一个数学模型。该模型可预测机油耗随气缸孔粗糙度变化的期望值,并能提出确定和控制最低机油耗的重要气缸孔表面粗糙度参数。 | Hill S H Kantola T C Brown J R 孙书麒 | 1998 | 国外内燃机1998，30，3： | 2 |
| 8 | Multiple DNA glycosylas es for repair of 8-oxoguanine and their potential in vivo functions 显示文摘 | Hazra T K Hill J W Izumi T | 2001 | Prog Nucleic Acid Res Mol Biol2001，68，： | 1 |
| 9 | High-efficiency Agrobacterium-mediated transformation of Brachypodium distachyon inbred line Bd21-3 显示文摘 | Vogel J Hill T | 2008 | Plant Cell Report2008，27，： | 1 |
| 10 | Methods for assessing the composition and diversity of soil microbial communities显示文摘 | Hill G T Mitkowski N A Aldrich-Wolfe L | 2000 | Applied Soil Ecology2000，15，1： | 1 |
| 11 | The Dynamics of Product and Process Innovation显示文摘 | HILL CHRISTOPHER T UTYERBACK JAMES M | 1980 | Management Review1980，69，： | 1 |
| 12 | The effect of glucose on the control of carbohydrate m343 etabolism in ripening bananas显示文摘 | HILL S A AP REES T | 1995 | Planta1995，196，： | 1 |
| 13 | Low dose twice daily fractlonated X2 irradiation of ovarian tumor cells in vitro generates drug-resistant cellsoverexp ressing two muhidrug resistance associated proteins, P-glycoprotein and MRP1 显示文摘 | Hill B T Moran E Etievant C | 2000 | Anticancer Drug2000，11，3： | 1 |
| 14 | The angle stable locking proximal humerus plate(LPHP) for proximal humeral fractures using a small anterior lateral deltoid splitting approach technique and first results显示文摘 | Hill H Hepp P Rose T | 2004 | Zentralbl Chir2004，129，1： | 1 |
| 15 | Solution proper- ties of star and linear poly(N-isopropylaerylamide)显示文摘 | Plummer R Hill D J T Whittaker A K | 2006 | Macromolecules2006，39，24： | 1 |
| 16 | Investigations into effective methods for assessing the condition of insulation in aged power transformers显示文摘 | Darveniza M Saha T K Hill D J T | 1998 | IEEE Transactions on Power Delivery1998，13，4： | 1 |
| 17 | Modeling microwave heating显示文摘 | Hill J M Merchant T R | 1996 | Applied Mathematical Modeling1996，20，1： | 1 |
| 18 | A dynamical model for simulation of animal waste digestion 显示文摘 | Hill D T Barth C | 1977 | Journal of Water Pollution Control Association1977，10，： | 1 |
| 19 | Netizens in Combat:Conflict on theInternet in Indonesia显示文摘 | David T Hill Krishna Sen | 2002 | Asian Studies Review2002，，2： | 1 |
| 20 | Polyoxometalates in medicine 显示文摘 | RHULE J T HILL C L JUDD D A | 1998 | Chem Rev1998，98，1： | 1 |
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