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| 1 | Treatment of Budd-Chiari syndrome with a focus on transjugular intrahepatic portosystemic shunt显示文摘AIM:To evaluate long-term complications and survival in patients with Budd-Chiari syndrome (BCS) referred to a Danish transjugular intrahepatic portosystemic shunt (TIPS) centre.METHODS:Twenty-one consecutive patients from 1997-2008 were retrospectively included [15 women and 6 men,median age 40 years (range 17-66 years)].Eighteen Danish patients came from the 1.8 million catchment population of Aarhus University Hospital and three patients were referred from Scandinavian hospitals.Management consisted of tests for underlying haematological,endocrinological,or hypercoagulative disorders parallel to initiation of specific treatment of BCS.RESULTS:BCS was mainly caused by thrombophilic (33%) or myeloproliferative (19%) disorders.Fortythree percents had symptoms for less than one week with ascites as the most prevalent finding.Fourteen (67%) were treated with TIPS and 7 (33%) were manageable with treatment of the underlying condition and diuretics.The median follow-up time for the TIPS-treated patients was 50 mo (range 15-117 mo),and none required subsequent liver transplantation.Ascites control was achieved in all TIPS patients with a marked reduction in the dose of diuretics.A total of 14 TIPS revisions were needed,mostly of uncovered stents.Two died during follow-up:One non-TIPS patient worsened after 6 mo and died in relation to transplantation,and one TIPS patient died 4 years after the TIPS-procedure,unrelated to BCS.CONCLUSION:In our BCS cohort TIPS-treated patients have near-complete survival,reduced need for diuretics and compared to historical data a reduced need for liver transplantation. | Anders Bay Neumann Stine Degn Andersen Dennis Tφnner Nielsen Peter Holland-Fischer Hendrik Vilstrup Henning Grφnbk | 2013 | World Journal of Hepatology2013，5，1： | 5 |
| 2 | 鸟类对猫捕食敏感性的种间差异研究(英文)显示文摘 | Anders Pape MφLLER Johannes ERRITZφE Jan Tφttrup NIELSEN | 2010 | Chinese Birds2010，，2： | 3 |
| 3 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 4 | 动态增强磁共振参数分析法评价NPI-2358对肿瘤的早期抗血管作用显示文摘目的:通过分析T1加权像下动态增强磁共振(DCE-MR)参数变化,探讨新型血管阻断剂NPI-2358对肿瘤的早期抗血管疗效。方法:小鼠C3H乳腺癌模型经腹腔注射7.5mg/kgNPI-2358溶液,置于7-T波谱成像系统的动态增强磁共振内,分别采集注射前后肿瘤区域的T1图像,利用Mat-lab2008软件分析数据。结果:NPI-2358组,与处理前相比,处理后1、3和6h的半定量参数IAUC均明显降低,P均<0.05;动力学参数Ktrans,与处理前相比,处理后3h明显降低,P<0.05;对照组,处理前后差异无统计学意义。结论:NPI-2358是一类起效、恢复均较为迅速的血管阻断剂,对肿瘤有早期的抗血管疗效。 | 沈媛媛 刘成霞 Bertelsen L B Nielsen T Horsman M R Stoedkilde-Joerrgensen H | 2010 | 中华肿瘤防治杂志2010，17，7： | 2 |
| 5 | Identification of small Hfq-binding RNAs in Listeria monocytogenes显示文摘 | Christiansen J K Nielsen J S Ebersbach T | 2006 | RNA2006，12，： | 1 |
| 6 | Dynamic Mechanic Properties of Paniculate-filled Composites显示文摘 | Lewis T Nielsen L | 1970 | Journal of Applied Polymer Science1970，14，6： | 1 |
| 7 | High efficiency beam splitter for multifocal multiphoton microscopy 显示文摘 | NIELSEN T FRICKE M HELLWEG D | 2001 | J Microsc2001，201，3： | 1 |
| 8 | Reinforced Concrete Response to Simulated Earthquakes 显示文摘 | TAKEDA T SOZEN M A NIELSEN N N | 1970 | Journal of the Structural Engineering ASCE1970，96，12： | 1 |
| 9 | Do g-teen areas affect health? Results froma Danish survey on the use of green areas and health indicators显示文摘 | Nielsen T S Hansen K B | 2007 | Health Place2007，13，： | 1 |
| 10 | Reinforced concrete response to simulated earthquake显示文摘 | TAKEDA T SOZEN M A NIELSEN N N | 1970 | Proc ASCE1970，，12： | 1 |
| 11 | Blocking enzyme-linked immunosorbent assay for detection of antibodies to Actinobacillus pleuropneumoniae serotype 2显示文摘 | Nielsen R Plambeck T Foged N T | 1991 | J Clin Microbiol1991，29，4： | 1 |
| 12 | Barley genotypes with long root hairs sustain high grain yields in low- P field显示文摘 | Gahoonia T S Nielsen N E | 2004 | Plant Soil2004，262，： | 1 |
| 13 | Cyclic AMP induced neuronal differentiation via activation of p38 mitogen-activated protein kinase显示文摘 | Hansen T O Rehfeld J F Nielsen F C | 2000 | J Neurochem2000，75，5： | 1 |
| 14 | Comparative metabolic network analysis of two xylose fermenting recombinant Saccharomyces cerevisiae strains显示文摘 | Grotkjaer T Christakopoulos P Nielsen J | 2005 | Metab Eng2005，7，56： | 1 |
| 15 | Leaf surface chemicals from Nicotiana affecting germination of Peronospora tabacina (Adam) sporangia 显示文摘 | Kennedy B S Nielsen M T Severson R F | 1992 | J Chem Ecol1992，18，： | 1 |
| 16 | Industrial enzymes 显示文摘 | Schafer T Rorchert T B Nielsen V S | 2007 | Advances in Biochemical Engineering/Biotechnology2007，105，： | 1 |
| 17 | A lignan from needles of himalayan Taxus baccata 显示文摘 | Fonseca S F Nielsen T L Rhveda E A | 1978 | Phytochemistry1978，17，： | 1 |
| 18 | Cellular delivery and antisense effects of peptide nucleic acid conjugated to polyethyleneimine via disulfide linkers 显示文摘 | Berthold P R Shiraishi T Nielsen P E | 2010 | Bioconjug Chem2010，21，10： | 1 |
| 19 | Recent trend in risk assessment of formaldehyde exposures from indoor air显示文摘 | Nielsen G D Larsen S T Wolkoff P | 2013 | Archives of Toxicology2013，87，1： | 1 |
| 20 | Inheritance of glandular trichomes in tobacco显示文摘 | Johnson J C Nielsen M T Collins G B | 1988 | Crop Science1988，28，： | 1 |
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