|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 3 | Skin fold thickness at abdomen:a simple anthropometric measurement may compliment metabolic syndrome definition in patients with normal waist circumference显示文摘Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF at A8 point (SFA8) on Erdheim diagram(MetSSFA8) in essential hypertensive patients. Subjects and Methods Medical records of 268 essential hypertensive patients (126males and 122 females) were analyzed, including 210 non-diabetic patients (NDM group) and 58 patients with diabetes (DM group).The mean age was 61.4 ± 9.9 and 59.0 ± 11.0 years, respectively. The control group consisted of 90 non-diabetic, non-hypertensive patients with a mean age of 58.0 ± 11.3 years. The proposed MetSSFA8 definition included SFA8 specific values ( ≥30 mm in female and ≥27 mm in male) and at least two of the following: raised triglyceride levels ( ≥1.7 mmol/L), or specific treatment for this lipid abnormality; raised blood pressure (SBP≥130 mmHg and/or DBP≥85 mmHg), or treatment of previously diagnosed hypertension;reduced HDL-cholesterol (< 1.03 mmol/L in men, <1.29 mmol/L in women), or specific treatment for this lipid abnormality; raised fasting plasma glucose (≥5.6 mmol/l), or previously diagnosed DM. Metabolic Syndrome by the National Cholesterol Education Program and International Diabetes Federation definitions were determined with abdominal obesity defined by Asia-Pacific criteria for waist circumference (NCEPA and IDFA). Results The percentage of MetS as defined by NCEPA, IDFA and MetSSFA8 in NDM group was lower than that of NCEPA, IDFA and MetSSFA8 in DM group [OR=7.7 (95%CI, 2.9-20.2) and 2.5 (95%CI, 1.4-4.8) and 2.7(95%CI, 1.3-5.6), respectively] and higher than that of the control group [OR=53.3 (95%CI, 16.7-170.6), 5.8 (95%CI, 2.6-13.2) and18.8 (95%CI, 7.3-48.7), respectively]. The percentage of MetS by NCEPA, IDFA and MetSSFA8 in males in NDM group was lower than the percentage of MetS by NCEPA, IDFA and MetSSFA8 in females in NDM group (50.8% and 77.9%, P< 0.001; 15,9% and 67.2%, P< 0.001; 60.3% and 73.8%, P <0.05, respectively). In subjects with normal WC or both normal WC and BMI, the percentage of MetS by SFAS was higher than that the percentage of MetS by NCEPA (36.9% and 50.8%, P< 0.05 and 36.0% and 51.0%, P< 0.05).The sensitivity, specificity, false positive rate, positive predictive value, negative predictive value of MetSSFA8 assessed with NCEPA definitions were 0.87, 0.73, 0.27, 0.79 and 0.82, respectively. There was a close agreement between MetSSFA8 and NCEPA (The coefficient of Kapa was 0.60, P< 0.001). Conclusions The MetSSFA8 definition was developed which may be useful in order to define and manage MetS in patients with normal WC or normal weight. | Toan C Nguyen Thai Q Ngo Son V Nguyen Hieu T Luong Khoa TA Pham Cong D Nguyen | 2006 | Journal of Geriatric Cardiology2006，3，2： | 2 |
| 4 | Head and neck injuries in fatal motorcycle collisions as determined by detailed autopsy显示文摘 | Ouellet JV Smith TA | 2002 | Annu Proc Assoc Adv Automot Med2002，46，： | 1 |
| 5 | Human T cell lymphotropic virus type Ⅰ Tax activates IL-15R alpha gene expression through an NF-kappa B site显示文摘 | Mariner JM Lantz V Waldmann TA | 2001 | J Immunol2001，166，4： | 1 |
| 6 | The effects of omega3fatty acids and coenzyme Q10on blood pressure and heart rate in chronic kidney disease:a randomized controlled trial显示文摘 | Mori TA Burke V Puddey I | 2009 | J Hypertens2009，27，： | 1 |
| 7 | Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo 显示文摘 | Fulga TA Elson-Schwab I Khurana V | 2007 | Nat Cell Boil2007，9，： | 1 |
| 8 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 9 | Activity-driven local ATP synthesis is required for synaptic function显示文摘 | Rangaraju V Calloway N Ryan TA | 2014 | Cell2014，156，4： | 1 |
| 10 | RotaryPumpwith Cycloidal- involute Rotor Profile显示文摘 | RYAZANTSEV V M STRELNIK TA | 1995 | Chemical and Petroleum Engineering1995，31，5： | 1 |
| 11 | Clopidogrel Resistance Is Associated With Increased Risk of Recurrent At herothrombotic Events in patients With Acute Myocardial Infarction显示文摘 | Matetzky S Shenkman B Guet ta V | 2004 | Circulation2004，109，25： | 1 |
| 12 | Removal of PCR inhibitors by silica membranes:evaluating the Amplicor Mycobacterium tuberculosis kit显示文摘 | Boddinghaus B Wichelhaus TA Brade V | 2001 | J Clin Microbiol2001，39，10： | 1 |
| 13 | Self- Phase modulation-based integrated optical regeneration in chalcogenide waveguides 显示文摘 | TA'EED V G SHOKOOH-SAREMI M FU L | 2006 | IEEE Journal of Selected Topics in Quantum Electronics2006，12，3： | 1 |
| 14 | Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer显示文摘 | Jarvinen TA Tanner M Rantanen V | 2000 | Am J Pathol2000，156，： | 1 |
| 15 | Gastric bacterial overgrowth accompanies profound acid suppression 显示文摘 | Patel TA Abraham P Ashar V J | 1995 | Indian J Gastroenterol1995，14，4： | 1 |
| 16 | Graph -based tools for microscopic cellular image segmentation 显示文摘 | TA V T LEZORAY O ELMOATAZ A | 2009 | Pattern Recognition2009，42，6： | 1 |
| 17 | Amplificationand deletion of topoisomerase Ⅱalpha associate with ErbB-2amplification and affect sensitivity to topoisomerase Ⅱinhibitor doxorubicin in breast cancer显示文摘 | Jarvinen TA Tanner M Rantanen V | 2000 | Am J Pathol2000，156，3： | 1 |
| 18 | Review of immunologi- cal and immunopathological findings in schizophrenia显示文摘 | Rothermundt M Arolt V Bayer TA | 2001 | Brain Behav Immun2001，15，4： | 1 |
| 19 | Cervicogenic headache;diagnostic criteria显示文摘 | Sjaastad O Fredriksen TA Pfaffejirath V | 1990 | Headache1990，30，11： | 1 |
| 20 | Efalizumab induced bullous pem- phigoid显示文摘 | Duong TA Buffard V Andr6 C | 2010 | Am Acad Dermato12010，62，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员