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	题名	作者	年代	出处	被引量
1	Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production.	Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi	2014	World Journal of Gastroenterology2014，20，27：	4
2	An application of the AHP in vendor selection of a telecommunications system显示文摘	Tam C Y Tummala V M	2001	International Journal of Management Science2001，29，2：	1
3	An application of the AHP in vendor selection of a telecommunications system 显示文摘	Tam M C Y Tummala V M R	2001	O- mega2001，29，2：	1
4	Non-structural fuzzy decision support system for evaluation of construction safety management system 显示文摘	TAM C M TONG T K L CHIU G C V	2002	International Journal of Project Manage- ment2002，20，4：	1
5	An application of the AHP in vendor selection of a telecommunications system显示文摘	Tam M C Tummala V M	2001	Omega2001，29，2：	1
6	Parameters for assessing recycled aggregate and their correlation 显示文摘	Tam V W Y Tam C M	2009	Waste Management and Research2009，27，1：	1
7	Micro - structural analysis of recycled aggregate concrete produced from two - stage mixing approach显示文摘	TAM V W Y GAO X F TAM C M	2005	Cement and Concrete Research2005，35，6：	1
8	An application of the AHP in vendor sdection of a telecommunications system显示文摘	TAM M C TUMMALA V M	2001	Omega2001，29，2：	1
9	Green construction assessment for environmental management in the construction indus- try of Hong Kong显示文摘	Tam C M Tam V W Y Tsui W S	2004	International Journal of Project Management2004，22，7：	1
10	An Application of the AHP in Vendor Selection of a Telecommunications System显示文摘	TAM C Y TUMMALA V M	2001	Int J Manage Sci2001，29，2：	1
11	An application ofthe AHP in vendor selection of a telecommun-ications system显示文摘	TAM C Y TUMMALA V M	2001	Omega2001，29，2：	1
12	Green construction assessment for environmental management in the construction industry of Hong Kong 显示文摘	Tam C M Tam V W Y Tsui W S	2004	International Journal of Project Management2004，22，7：	1
13	An application of the AHP in vendor selection of a telecommunications system 显示文摘	Tam C Y Ttnnmala V M	2001	International Journal of Management Science2001，29，2：	1
14	Analysis of results from large scale hydrocarbon gas explosions显示文摘	Shearer M J Tam V H Y Corr B	2000	Journal of Loss Prevention in the Process Industries2000，，13：	1
15	Towards adoption of prefabrication in construction显示文摘	TAM V W Y TAM C M ZENG S X	2007	Building and Environment2007，42，10：	1
16	PGC-1[alpha] promotes recovery after acute kidney injury during systemic inflammation in mice显示文摘	Tran Mei Tam Denise Bardia Amit Bhasin Manoj Rowe Glenn C Kher Ajay Zsengeller Zsuzsanna K Akhavan-Sharif M Reza Khankin Eliyahu V Saintgeniez Magali David Sascha Burstein Deborah Karumanchi S Ananth Stillman Isaac E Arany Zoltan Parikh Sa	2011	Journal of Clinical Investigation2011，，10：	1
17	Use of Larger Sized Aortic Homograft Conduits in Right Ventricular Outflow Tract Recon-struction显示文摘	Tam R K Tolan M J Zamvar V Y	1995	J Heart Valve Dis1995，4，6：	1
18	Mammary gland-specific secretion of biologically active immunosuppressive agent cytotoxic-T-lymphocyte antigen 4 human immunoglobulin fusion protein (CTLA4Ig) in milk by transgenesis显示文摘	LUI V C TAM P K LEUNG M Y	2003	J Immunol Methods2003，277，12：	1
19	An application of the AHP invendor selection of a telecommunications system 显示文摘	Tam C Y Tummala V M	2001	International Journal of Management Science2001，29，2：	1
20	Removal of cement mortar remains from recycled aggregate using pre-soaking approaches显示文摘	TAM V W Y TAM C M LE K N	2007	Resources Conservation and Recycling2007，50，1：	1

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