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1外刊拾贝显示文摘1.根据2018年美国糖尿病学会标准诊断中国糖尿病患病率:全国横断面研究目的:评估糖尿病患病率及其危险因素。设计:基于人群的横断面研究。背景:2015-2017年中国大陆31省份全国横断面数据。调查对象:75880名18周岁及以上代表中国大陆人口的成年人样本。主要观察指标:根据2018年美国糖尿病学会和世界卫生组织标准诊断中国成人不同性别、区域和种族的糖尿病患病率。通过问卷的方式记录调查对象的社会人口学信息、生活方式和疾病史。单忠艳 Li Y Teng D Shi X Ba J 王看然 李启富 Wang K Hu J Yang J 2020国际内分泌代谢杂志2020,40,5:42
2Sequential organ failure assessment score is superior to other prognostic indices in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index of severity in acute pancreatitis(BISAP),Glasgow score,harmless acute pancreatitis score(HAPS),Ranson’s score,and sequential organ failure assessment(SOFA)evaluate AP severity and predict mortality.AIM To evaluate these indices'utility in predicting severity,intensive care unit(ICU)admission,and mortality.METHODS A retrospective analysis of 653 patients with AP from July 2009 to September 2016 was performed.The demographic,clinical profile,and patient outcomes were collected.SAP was defined as per the revised Atlanta classification.Values for APACHE II score,BISAP,HAPS,and SOFA within 24 h of admission were retrospectively obtained based on laboratory results and patient evaluation recorded on a secure hospital-based online electronic platform.Data with<10%missing data was imputed via mean substitution.Other patient information such as demographics,disease etiology,and patient outcomes were also derived from electronic medical records.RESULTS The mean age was 58.7±17.5 years,with 58.7%males.Gallstones(n=404,61.9%),alcohol(n=38,5.8%),and hypertriglyceridemia(n=19,2.9%)were more common aetiologies.81(12.4%)patients developed SAP,20(3.1%)required ICU admission,and 12(1.8%)deaths were attributed to SAP.Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP(92.6%,80.2%respectively),ICU admission(100%),and mortality(100%).While SOFA and BISAP demonstrated lowest sensitivity in predicting SAP(13.6%,24.7%respectively),ICU admission(40.0%,25.0%respectively)and mortality(50.0%,25.5%respectively).However,SOFA demonstrated the highest specificity in predicting SAP(99.7%),ICU admission(99.2%),and mortality(98.9%).SOFA demonstrated the highest positive predictive value,positive likelihood ratio,diagnostic odds ratio,and overall accuracy in predicting SAP,ICU admission,and mortality.SOFA and Ranson’s score demonstrated the highest area under receiver-operator curves at 48 h in predicting SAP(0.966,0.857 respectively),ICU admission(0.943,0.946 respectively),and mortality(0.968,0.917 respectively).CONCLUSION The SOFA and 48-h Ranson’s scores accurately predict severity,ICU admission,and mortality in AP,with more favorable statistics for the SOFA score.Thomas Zheng Jie Teng Jun Kiat Thaddaeus Tan Samantha Baey Sivaraj K Gunasekaran Sameer P Junnarkar Jee Keem Low Cheong Wei Terence Huey Vishal G Shelat 2021World Journal of Critical Care Medicine2021,10,6:9
3Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS.Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight 2010Cellular & Molecular Immunology2010,7,3:3
4Instabihties of strategic alliances:An internal tensions perspective显示文摘Das T K Teng B S 2000Organization Science2000,11,1:1
5Multivariate analysis of soil heavy metal pollution and landscape pattern in Changhua County in Taiwan 显示文摘LIN Y P TENG T P CHANG T K 2002Landscape and Urban Planning2002,62,1:1
6Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells:the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways显示文摘Moerman EJ Teng K Lipschitz DA 2004Aging Cell2004,3,6:1
7A resource-based theory of strategic alliances显示文摘DAS T K TENG Bing Sheng 2000Journal of Management2000,26,1:1
8Optimal pricing and ordering policy under permissible delay in payments显示文摘Teng J T Chang C T Goyal S K 2005International Journal of Production Economics2005,97,:1
9A resource - based theory of stra- tegic alliances 显示文摘Das T K Teng B - S 2000Journal of Management2000,26,1:1
10Trust, control, and risk in strategic alliances : An integrated framework 显示文摘Das T K Teng B S 2001Organization Studies2001,22,2:1
11A simplified preparation of mesoporous carbon and the examination of the carbon accessibility for electric double layer formation显示文摘LIU H Y WANG K P TENG H 2005Carbon2005,43,3:1
12The dynamics of alliance conditions in the alliance development process 显示文摘DAS T K Teng B S 2002Journal of Management Studies2002,39,5:1
13Pharmacokinetics, pharmacody- namics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y (12) receptor antagonist, in healthy subjects显示文摘Teng R Butler K 2010Eur J Clin Pharmacol2010,66,5:1
14Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/ stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/ BMP signaling pathways显示文摘Moerman EJ Teng K Lipschitz DA 2004Aging Cell2004,3,6:1
15Instabilities of strategic allian- ces: An internal tensions perspective显示文摘Das T K Teng B S 2000Organization Science2000,11,1:1
16Aging activates adipogenic and suppresses osteogenic programs in mesen-chymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways 显示文摘Moerman E J Teng K Lipschitz DA 2004Aging Cell2004,3,6:1
17Superior mechanical properties of epoxy composites reinforced by 3Dinterconnected graphene skeleton显示文摘NI Y CHEN L TENG K Y 2015ACS Appl Mater Inter2015,7,11:1
18Managing Risks in Strategic Alliances 显示文摘Das T K Teng B S 1999Academy of Management Executive1999,13,4:1
19Optimal pricing and ordering policy under permissib delay in payments显示文摘Teng J T Chang C T Goyal S K 2005International Journal of Production Economics2005,97,:1
20Instabilities of strategic alliances:an internal tensions perspective显示文摘Das T K Teng B 2000Organization Science2000,11,1:1
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