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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Changes in protein synthesis during drought conditioning in roots of jack pine seedlings 显示文摘 | Michael B M Mohan S Terence J B | 1994 | Tree Physiology1994，14，： | 1 |
| 3 | Effects of UVB preconditioning on heat tolerance of cucumber ( Cucumis sativus L.)显示文摘 | Thomas Teklemariam Terence J Blake | 2003 | Environmental and Experimental Botany2003，，2： | 1 |
| 4 | A Syntaxin 1, Galpha(o), and N-Type Calcium Channel Complex at a Presynaptic Nerve Terminal : Analysis by Quantitative Immunocolocalization 显示文摘 | Qi L Anthony L Terence J | 2004 | J Neuresci2004，24，： | 1 |
| 5 | Ultrasonic deposition of cells on a surface显示文摘 | JEREMY J MICHAEL J TERENCE C | 2004 | Biosensors Bioelectronics2004，19，： | 1 |
| 6 | Comparative evaluation of computer methods for calculating the best fit sinusoid to the high purity sine wave显示文摘 | KUFFEL J MCCOMB TERENCE R RYSZARD M | 1987 | Medical and Biological Engineering and Computing1987，13，3： | 1 |
| 7 | Altantic Salmon fed L-camitine exhibit altered intermediary metabolism and reduced tissue lipid,but no change in growth rate 显示文摘 | Hong J Bradley Terence M | 1996 | J Nutr1996，126，8： | 1 |
| 8 | A Sensitive Procedure for the Rapid Determination of Arsenic(Ⅲ) by Flow Injection Analysis and Chemiluminescence Detection显示文摘 | Terence J Cardwell Spas D Kolev | 2005 | Anal Chim Acta2005，554，： | 1 |
| 9 | Robust uncertaintyprinciples: exact signal reconstruction from highly in-complete frequency information 显示文摘 | Candes E J Justin R Terence T | 2006 | IEEE Transac-tions on Information Theory2006，52，2： | 1 |
| 10 | The maturity of project management in different industries:An investigation into variations between project management models显示文摘 | Cooke-Davies Andrew Arzymanow | 2000 | Project Management2000，21，： | 1 |
| 11 | Barthel index for stroke trials:development,properties,and application显示文摘 | Terence J Q Peter L David J S | 2011 | Stroke2011，42，： | 1 |
| 12 | Robust uncertainty principles: Exact signal reconstruction from highly incomplete frequency information 显示文摘 | CANDES E ROMBERG J TERENCE TAO | 2006 | IEEE Trans On Information Theory2006，52，2： | 1 |
| 13 | Structural, electrical and mechanical properties of templated silsesquioxane porous films 显示文摘 | YU S Z TERENCE K S WEI J | 2005 | Microelectronic Engineering2005，77，2： | 1 |
| 14 | The unique properties of a new stimulant 显示文摘 | Terence J L French J | 1991 | Aviat space environ Med1991，62，： | 1 |
| 15 | Solution chemistry during the lag phase and exponential phase of pyrite oxidation by Thiobaeillus ferrooxidans 显示文摘 | Jae-Young Yu Terence J Me Genity | 2001 | Chemical Geology2001，175，： | 1 |
| 16 | The interest-major congruence and collge success relation: a longitudinal study显示文摘 | Terence J G Tmcey Steven B Robbins | 2006 | Journal of Vocational Behavior Volume 69 Issue l2006，8，10： | 1 |
| 17 | Robust uncertainty principles: Exact signal reconstruction from highly incomplete frequency information显示文摘 | CANDES E ROMBERG J TERENCE T | 2006 | IEEE Transaction on Information Theory2006，52，2： | 1 |
| 18 | Mapping tropical forest structure in southeastern Madagascar using remote sensing and artificial neural networks显示文摘 | Carter Ingram J Terence P Dawson | 2005 | Remote Sensing of Environment2005，94，： | 1 |
| 19 | A sensitive procedure for the rapid determination of arsenic(Ⅲ) by flow injection analysis and chemiluminescence detection显示文摘 | SAKCHAI SATIENPERAKUL TERENCE J CARDWELL SPAS D KOLEV | 2005 | Analytica Chimica Acta2005，，554： | 1 |
| 20 | 查看详情显示文摘 | Stuart J D Terence K A | | 0，，： | 1 |
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