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| 1 | 液相飞行时间质谱(LC/MSD TOF)和液相色谱/离子阱质谱(LC/MSD Trap)测定色拉蔬菜中的氯烟碱类杀虫剂显示文摘本工作考察了液相色谱/飞行时间质谱检测器(LC/MSDTOF)和液相/离子阱质谱检测器(LC/MSDTrap)联用技术分析一些氯烟碱类杀虫剂的可行性.杀虫剂包括:啶虫咪(acetamiprid),吡虫啉(imidacloprid)和噻虫啉(thiacloprid).色拉蔬菜有四种:番茄、辣椒、莴苣和黄瓜.本文介绍的内容包括三种氯烟碱类杀虫剂的LC/MSDTOF和LC/MSDTrap质谱,TOF获得的实验分子式和四种蔬菜基质中氯烟碱类杀虫剂的MS/MS碎片离子.同时也将详细介绍样品制备程序以及色拉蔬菜中杀虫剂的回收、最低检测限(MDL)的质谱质量、线性,使用TOF和Trap对纯溶剂和四种蔬菜提取物中杀虫剂的定量分析.给出了来自市场的实际色拉蔬菜样品中杀虫剂的分析结果. | Imma Ferrer EMichael Thurman Jerry Zweigenbaum | 2005 | 环境化学2005，24，3： | 8 |
| 2 | 液相色谱/离子阱质谱和飞行时间质谱分析橄榄油中的特丁津除草剂显示文摘本文摘要介绍了液相色谱/离子阱质谱和液相/飞行时间质谱对橄榄油中特丁津的定性定量分析.详细介绍了样品处理,包括液液萃取和以氨基硅胶为基质分散的固相萃取法.样品的净化采用Florisil硅土小柱,用乙腈洗脱溶质.液相色谱/离子阱质谱的MS/MS模式采集特征离子m/z174.而利用液相/飞行时间质谱进行精确质量数分析(\[M+H\]+,m/z230),同时得到碎片的精确质量数和特征同位素分布.对于飞行时间质谱测得的质量精度小于ppm.此方法具有高灵敏度、线性好及精度高的优点.液相/离子阱质谱和飞行时间质谱可以作为橄榄油中特丁津的常规方法. | Imma Ferrer Michael Thurman Jerry Zweigenbaum | 2005 | 环境化学2005，24，6： | 5 |
| 3 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 4 | 脂质过氧化在再灌流性肝损伤中的作用显示文摘采用低流率-再灌流模型研究脂质过氧化在再灌流性肝损伤中的作用,肝脏经过90min低速率灌流未见明显损伤,当灌流速率恢复到正常后中心静脉周围区(PC区)细胞发生迅速不可逆损害,并伴有丙二醛生成率大幅度上升,低速率灌流期间,灌流液中黄嘌呤与次黄嘌吟浓度由原来的1.5和3.6μmol·L^(-1)逐步升高至5.5和11.5μmol·L^(-1),自由基清除剂儿茶酸能使再灌流期丙二醛生成率由295 nm01·g^(-1)·h^(-1)下降至109 nmol·g^(-1)·h^(-1),并使LDH释放率减少约50%,PC区细胞死亡率减少89%,再灌流初期用氮饱和灌流液冲洗3 min,使再灌流所致的LDH释放下降约50%,PC区细胞死亡率减少84%,别嘌吟醇(2~6mmol·L^(-1))对防止再灌流性肝损伤表现出明显的剂量效应关系。 与预计结果相反低浓度别嘌呤醇(0.5~1mmol·^(-1))能增加再灌流性肝损伤,400μmol·L^(-1)黄嘌呤则使再灌流性肝损伤明显减轻,其代谢产物尿酸对降低再灌流时丙二醛生成率以及细胞损害均表现出明显的剂量反应关系。 | 钟沚 周炯亮 Ronald G THURMAN | 1992 | 中国药理学与毒理学杂志1992，6，2： | 4 |
| 5 | Association of types of diabetes and insulin dependency on birth outcomes显示文摘BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy outcomes.AIM To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes status.METHODS Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant mortality.Confounders included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm birth.Bivariate and multivariate logistic regression assessed differences in outcomes by diabetes status.RESULTS Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic women.Women with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic women.CONCLUSION Diabetes is associated with the poor birth outcomes.Clinical management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes. | Pamela K Xaverius Steven W Howard Deborah Kiel Jerry E Thurman Ethan Wankum Catherine Carter Clairy Fang Romi Carriere | 2022 | World Journal of Clinical Cases2022，10，7： | 2 |
| 6 | LC/TOF MS分子特征数据库检索方法进行食品中600种农药的自动筛选显示文摘通过液相色谱/飞行时间质谱在正离子模式下全扫描精确质谱测定,建立了分子特征(MF)算法进行数据库检索的方法用于筛选食品提取物中600种农药及其降解产物。数据库检索将实际化合物检测和鉴定中得到的离子的精确质量数收集起来,并且将它们与数据库中化合物的单一同位素的准确质量数进行比较。筛选标准包括:±5 ppm精确质量窗口;±0.2分钟保留时间窗口;最小峰面积计数1000(信噪比约为10:1)。检出限和保留时间是由600种化合物中的100种来确定,其中34%的化合物的检出限小于0.01mg/kg,95%的化合物的检出限小于0.5 mg/kg。与需要几小时到几天的手工方法相比,分子特征算法的优势在于它可以在几分钟内灵敏快速地筛选几百种化合物。 | E.Michael Thurman Imma Ferrer Jerry A.Zweigenbaum | 2010 | 食品安全质量检测学报2010，1，3： | 2 |
| 7 | 中低收入国家癫痫过早死亡:国际抗癫痫联盟死亡率专业组系统评价显示文摘为了确定中低收入国家(Low-and middle-income countries,LMICs)癫痫相关的危险因素大小与过早死亡原因,专业组对来自LMICs(世界银行定义)的死亡率及癫痫相关文献报道进行系统检索,根据代表性,病例、诊断和死亡率的确证度对研究进行评估,并提取癫痫患者中的标准化死亡比(Standardized mortality ratios,SMR)和死亡率数据。研究调查了死亡的危险因素和原因。据估计,在高质量的群体研究中,癫痫患者年死亡率为19.8/1 000(9.7/1 000~45.1/1 000),加权中位SMR为2.6(1.3~7.2)。而临床队列研究显示的死亡率为7.1/1 000(1.6/1 000~25.1/1 000),加权中位SMR在男性中为5.0,女性中为4.5。在儿童和青少年、症状性癫痫或治疗依从性低的患者中发现了相对较高的SMR。群体研究显示,LMICs癫痫患者死亡的主要原因中直接归因于癫痫的平均比例死亡比(Proportional mortality ratio,PMR)为27.3%(5.0%~73.5%)。这些直接原因包括癫痫持续状态(报道的PMR为5.0%~56.5%)和癫痫猝死(Sudden unexpected death in epilepsy,SUDEP)(报道的PMR为1.0%~18.9%),与癫痫相关的间接死亡原因包括溺水、头部创伤和烧伤。LMICs癫痫患者的早亡率明显高于高收入国家。在LMICs,死亡率过高可能与患者难以获得医疗资源有关,例如发生癫痫持续状态时,以及包括溺水、头外伤和烧伤在内的可预防死因。这类过高的早亡率可以通过进行关于死亡风险的教育,提高治疗,包括抗癫痫药物治疗的可得性而大大降低。 | Levira F Thurman DJ Sander JW Hauser WA Hesdorffer DC Masanja H OdermattP Logroscino G Newton CR 陆璐 童馨 慕洁 | 2019 | 癫痫杂志2019，5，1： | 2 |
| 8 | Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice显示文摘 | Takehiko Uesugi Matthias Froh Gavin E. Arteel Blair U. Bradford Ronald G. Thurman | 2001 | Hepatology2001，，1： | 2 |
| 9 | Herbicides andtransformation products in surface waters of the Midwestern UnitedStates 显示文摘 | Battaglin W A Thurman E M Kalkhoff S J | 2003 | Journal of the American Water Resources Association2003，39，： | 1 |
| 10 | An evaluation of automode, a computer-controlled ventilator mode, with the Siemens Servo 300A ventilator, using a porcine model显示文摘 | Holt S J Sanders RC Thurman TL | 2001 | Respir Care2001，46，1： | 1 |
| 11 | Potent peroxisome proliferators inhibit beta- oxidation in the isolated perfused rat liver显示文摘 | Bojes H K and Thurman R G | 1996 | Toxicol Appl Pharmacol1996，140，： | 1 |
| 12 | Carolina rinse solution protects adenosine triphosphate-depleted hepatocytes against lethal cell injury显示文摘 | CURRIN R J THURMAN R G LEMASTERS J J | 1991 | Transplant Proc1991，23，： | 1 |
| 13 | An evaluation of automode,a com- puter-controlled ventilstor mode ,with the Siemens Servo 300A ventila- tor, using a porcine model 显示文摘 | Holt SJ Sanders RC Thurman TL | 2001 | Respir Care2001，46，1： | 1 |
| 14 | Information Content of a Single Pass of Phase-Delay Data Forma Short Baseline Connected Element Interferometer显示文摘 | Thurman S W | | 0，，101： | 1 |
| 15 | Preparative isolation of aquatic humic substances显示文摘 | Thurman E M Malcolm R L | | 0，，04： | 1 |
| 16 | High-level co-regulation in collaborative learning: How does it emerge and how is it sustained?显示文摘 | Simone Volet Mark Summers Joanne Thurman | 2008 | Learning and Instruction2008，，2： | 1 |
| 17 | Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome 显示文摘 | Thurman JM Marians R Emlen W | 2009 | Clin J Am Soc Nephrol2009，4，： | 1 |
| 18 | Probing human skin as an information-rich smart biological interface using MEMS sensors显示文摘 | Bhansali S Thurman H Hoath S B | 2002 | Microelectronics Journal2002，33，12： | 1 |
| 19 | Complementactivation induces dysregulation of angiogenic factors andcauses fetal rejection and growth restriction显示文摘 | Girardi G Yarilin D Thurman JM | 2006 | J Exp Med2006，203，： | 1 |
| 20 | The molecular meehanisms of copper and silver ions disinfection of haeteria aud virses显示文摘 | Thurman R B Gerba C P Bitton G | 1989 | Crit Rev Environ Control1989，18，4： | 1 |
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