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| 1 | Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis显示文摘This review describes the principal pathways of macroautophagy (i.e. autophagy), microautophagy and chaperone-mediated autophagy as they are currently known to occur in mammalian cells. Because of its crucial role as an accessory digestive organ, the liver has a particularly robust autophagic activity that is sensitive to changes in plasma and dietary components. Ethanol consumption causes major changes in hepatic protein and lipid metabolism and both are regulated by autophagy, which is significantly affected by hepatic ethanol metabolism. Ethanol exposure enhances autophagosome formation in liver cells, but suppresses lysosome function. Excessive ethanol consumption synergizes with hepatitis C virus (HCV) to exacerbate liver injury, as alcohol-consuming HCV patients frequently have a longer course of infection and more severe manifestations of chronic hepatitis than abstinent HCV patients. Alcohol-elicited exacerbation of HCV infection pathogenesis is related to modulation by ethanol metabolism of HCV replication. Additionally, as part of this mechanism, autophagic proteins have been shown to regulate viral (HCV) replication and their intracel-lular accumulation. Because ethanol induces autophagosome expression, enhanced levels of autophagic proteins may enhance HCV infectivity in liver cells of alcoholics and heavy drinkers. | Natalia A Osna Paul G Thomes Terrence M Donohue | 2011 | World Journal of Gastroenterology2011，17，20： | 5 |
| 2 | Conden- sation in horizontal tubes: part 2 New heat transfer model based on flow regimes 显示文摘 | HAJAL J E THOME J R CAVALLINI A | 2003 | International Jour- nal of Heat and Mass Transfer2003，46，18： | 1 |
| 3 | Riverbank stability analysis I: Theory 显示文摘 | OSMAN A M THOME C R | 1988 | Journal of Hydraulic Engineering1988，114，2： | 1 |
| 4 | Riverbank stability analysis II : Application 显示文摘 | THOME C R OAMAN A M | 1988 | Journal of Hydraulic Engineering1988，114，15： | 1 |
| 5 | Condensation in hori- zontal tubes, part 2 : new heat transfer model based on flow regimes 显示文摘 | Thome J R Hajal J E Cavallini A | 2003 | International Journal of Heat and Mass Transfer2003，46，18： | 1 |
| 6 | Determination of precipitable water from solar transmission显示文摘 | Thome K J Herman B M Reagan J A | 1992 | J Appl Meteor1992，31，： | 1 |
| 7 | Part I:presentation of the model显示文摘 | Thome J R Dupont V Jacobi A M Heat transfer model for evaporation in microchannels | 2004 | Int J Heat Mass Transfer2004，47，1416： | 1 |
| 8 | Permissive hypercapnia显示文摘 | Thome U H Carlo W A | 2002 | Semin Neonatol2002，7，： | 1 |
| 9 | 显示文摘 | Takeshita T Gschneidner Jr K A Thome D K | 1980 | Phy Rev B1980，21，： | 1 |
| 10 | Determination of precipitable water from solar transmission 显示文摘 | Thome K J Herman B M Reagan J A | 1992 | J Appl Meteor1992，31，： | 1 |
| 11 | Superconducting magnets for maglifter launch assist sleds显示文摘 | Schultz J H Radovinsky A Thome R J | 2001 | IEEE Transactions on Applied Superconductivity2001，，11： | 1 |
| 12 | Riverbank stability analysis I :Theory显示文摘 | Osman A M Thome C R | 1988 | Journal of Hydraulic Engineering ASCE1988，114，2： | 1 |
| 13 | Experimental and Analytical Investigation of FRP Strengthened Beam Response: Part I显示文摘 | Quantrill R J Hollawayl C Thome A M | 1996 | Magazine of Concrete Research1996，48，12： | 1 |
| 14 | Mobile phone use and stress,sleep disturbances,and symptoms of depression among young adults: a prospective cohort stud显示文摘 | Thomee S Harenstam A Hagberg M | 2011 | BMC Public Health2011，11，： | 1 |
| 15 | Ultrathin antibacterial polyammonium coatings on polymer surface显示文摘 | Thome J Hollander A Jaeger W | 2003 | Surface and Coatings Technology2003，174，9： | 1 |
| 16 | Randomized, doubleblind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis 显示文摘 | Cibere J Kopec JA Thome A | 2004 | Arthritis Rheum2004，51，5： | 1 |
| 17 | Evaluation of lower leg function in patients with Achilles tendinopathy 显示文摘 | Silbemagel KG Gustavsson A Thomee R | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，11： | 1 |
| 18 | Permissive hypercapnia显示文摘 | Thome U H Carlo W A | 2002 | Semin Neonatol2002，7，： | 1 |
| 19 | The use of sentinel node bi- opsy in the treatment of cancer of an accessory breast 显示文摘 | Thome AL Jackson A Yiangou C | 2003 | Breast2003，12，2： | 1 |
| 20 | Related articles, links hypothermia as a neuroprotective strategy in subarachnoid bemorrhage:a pathopbysiological review focusing on the acute phase显示文摘 | Thome C Schubert G A Schilling L | 2005 | Neurol Res2005，27，3： | 1 |
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