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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | FUSARIUM-ID v. 1.0: A DNA Sequence Database for Identifying Fusarium显示文摘 | David M. Geiser María del Mar Jiménez-Gasco Seogchan Kang Izabela Makalowska Narayanan Veeraraghavan Todd J. Ward Ning Zhang Gretchen A. Kuldau Kerry O’donnell | 2004 | European Journal of Plant Pathology (-)2004，，5： | 2 |
| 3 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH1 , EGFR , and NF1显示文摘 | Roel G.W. Verhaak Katherine A. Hoadley Elizabeth Purdom Victoria Wang Yuan Qi Matthew D. Wilkerson C. Ryan Miller Li Ding Todd Golub Jill P. Mesirov Gabriele Alexe Michael Lawrence Michael O'Kelly Pablo Tamayo Barbara A. Weir Stacey Gabriel Wendy Winckler | 2010 | Cancer Cell2010，，1： | 2 |
| 4 | Lithoautotrophic microbial ecosystems in deep basalt aquifers显示文摘 | Todd O Stevens James P McKinley | 1995 | Science1995，270，： | 1 |
| 5 | A study of chemical aging effects on HDD Fe-zeolite SCR catalyst显示文摘 | Silver R G Stefanick M O Todd B I | 2008 | Catalysis Today2008，72，： | 1 |
| 6 | Guidelines for Conscious Sedation and Monitoring During Gastrointestinal Endoscopy显示文摘 | J.Patrick Waring Todd H Baron William K Hirota Jay L Goldstein Brian C Jacobson Jonathan A Leighton J.Shawn Mallery Douglas O Faigel | 2003 | Gastrointestinal Endoscopy2003，，3： | 1 |
| 7 | Relationship between wear rate,surface pullout and microstructure during abrasive wear of alumina and alumina/SiC nanocomposites显示文摘 | MERINO J O L TODD R I | 2005 | Acta Materialia2005，53，12： | 1 |
| 8 | Nanofluid-Based Direct Absorption Solar Collector 显示文摘 | Todd P O Patrick E P Ravi S P | 2010 | Journal of Renewable and Sustainable Energy2010，2，03： | 1 |
| 9 | Hypothalamic insulin-like growth factor-I receptors are necessary for hormone-dependent luteinizing hormone surges: implications for female reproductive aging 显示文摘 | TODD B J MERHI Z O SHU J | 2010 | Endo- crinology2010，151，3： | 1 |
| 10 | Relationship between wear rate,surface pullout and microstructure during abrasive wear of alumina and alumina/SiC nanocomposites显示文摘 | Jose L O M Richard I Todd | 2005 | Acta Materialia2005，53，： | 1 |
| 11 | A study of chemical aging effects on HDD Fe–zeolite SCR catalyst显示文摘 | Silver R G Stefanick M O Todd B I | 2008 | Catalysis Today2008，72，： | 1 |
| 12 | Methods for increased accuracy in numerical reservoir simulators显示文摘 | M R Todd P M O'dell G J Hirasaki | 1972 | Soc Petrol Engry J1972，，12： | 1 |
| 13 | Remediation of 2, 4-dichlorophenol contaminated water by visible light-enhanced WO3 photoelectrocatalysis显示文摘 | Scott-Emuakpor E O Kruth A Todd M J | 2012 | Applied Catalysis B-Environmental2012，123，： | 1 |
| 14 | Effects of halo- thane, enflurane, isoflurane, and nitrous oxide on somato- sensory evoked potentials in humans显示文摘 | Peterson D O Drummond J C Todd M M | 1986 | Anesthesiology1986，65，1： | 1 |
| 15 | Pigmented soybean ( Glyclne max) seed coats accumulate proanthocyanidins during development 显示文摘 | Todd J J Vodkin L O | 1993 | Plant Physiol1993，102，： | 1 |
| 16 | Endothelial Progenitor Cells During Cerebrovascular Disease显示文摘 | Usman Ghani Ashfaq Shuaib Abdul Salam Aman Nasir Umar Shuaib Tom Jeerakathil Faiz Sher Fintan O’Rourke Abdul Majeed Nasser Brenda Schwindt Kathryn Todd | 2005 | Stroke2005，，1： | 1 |
| 17 | Quaternary organization of the Goodpasture autoantigen,the α3(IV)collagen chain:sequestration of two cryptic autoepitopes by intraprotomer interactions with the α4 and α5 NC1 domains显示文摘 | Borza DB Bondar O Todd P | 2002 | J Biol Chem2002，277，40： | 1 |
| 18 | In situ hybridization for thedetection of chicken anemia virus in formal infixed, paraffin embedded sections显示文摘 | Allan O M Smyth J A Todd D | 1993 | Avian diseases1993，37，： | 1 |
| 19 | Comparison of Numerical Codes for Geochemical Modelling of CO2 Storage in Target Sandstone Reservoirs显示文摘 | Gundogan O Mackay E Todd A | 2011 | Chemi- cal Engineering Research and Design2011，89，9： | 1 |
| 20 | A comparability study of 5 commercial KRAS tests 显示文摘 | Kelly O Todd J Sid S | 2010 | Diagnostic Pathology2010，5，： | 1 |
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