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| 1 | Transarterial radioembolization for hepatocellular carcinoma:An update and perspectives显示文摘In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability profile.This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications.Radioembolization is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical trials.Nevertheless,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for radioembolization.In addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery.Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib. | Rodolfo Sacco Valeria Mismas Sara Marceglia Antonio Romano Luca Giacomelli Marco Bertini Graziana Federici Salvatore Metrangolo Giuseppe Parisi Emanuele Tumino Giampaolo Bresci Ambra Corti Manuel Tredici Michele Piccinno Luigi Giorgi Carlo Bartolozzi Irene Bargellini | 2015 | World Journal of Gastroenterology2015，21，21： | 4 |
| 2 | Phylogenetics and biogeography of Theaceae based on sequences of plastid genes显示文摘尽管有 Theaceae 的几词法、分子的分析,几个突出的问题在部落之中包括争论关系留在家庭的 phylogenetics 和生物地理学 Gordonieae, Stewartieae 和 Stewartieae。在这研究,我们从除了 Laplacea,进行的种系发生的分析使用吝啬,可能性的,和贝叶斯的方法,代表所有类的 Theaceae 的 27 种类收集了多重质体基因的 DNA 序列,并且与石块刻度和分子的数据在一个贝叶斯的框架以内估计了分叉时间。我们的数据在家庭并且为 Theeae 的姐妹组关系为三个部落提供了进一步的支持给 Stewartieae 正 Gordonieae。在 Gordonieae 以内,我们的学习第一次为 Franklinia 和 Schima 的姐妹关系提供了强壮的分子的支持。在 Stewartieae 以内,我们的数据支持了 paraphyly 包括 Hartia 的 Stewartia。在 Stewartia 以内,我们的数据第一次建议北美人(NA ) 种类 Stewartia ovata 比到另外的 NA 种类 Stewartia malacodendron 与东方亚洲人(EA ) 种类有关仔细是更多。Biogeographic 分析显示 Gordonieae 的那分离的地方性的种可能从 EA 从 Stewartieae 的 NA 和那些发源。在这识别的 EA-NA 分离的对的分叉时间学习(在 Gordonieae 和 S 的 Franklinia 和 Schima。ovata (NA ) 和 Stewartia 的亚洲种类) 被估计在中间中新世。在 Gordonieae 和 Stewartieae 的人口交换可能发生在 Bering 陆地桥上在以前中间中新世。 | Mi-Mi LI Jian-Hua LI Peter DEL TREDICI Jeffrey CORAJOD Cheng-Xin FU | 2013 | Journal of Systematics and Evolution2013，51，4： | 2 |
| 3 | Staging of brain pathology related to sporadic Parkinson’s disease显示文摘 | Heiko Braak Kelly Del Tredici Udo Rüb Rob A.I de Vos Ernst N.H Jansen Steur Eva Braak | 2002 | Neurobiology of Aging2002，，2： | 2 |
| 4 | Staging of brain pathology related to sporadic Parkinson 's disease 显示文摘 | Braak H Del Tredici K Rub U | 2003 | Neurobiol Aging2003，24，2： | 1 |
| 5 | Staging of brain pathology related to sporadic Parkinson’s disease显示文摘 | Braak H Tredici KD Rüb U | 2003 | Neurobiol Aging2003，24，2： | 1 |
| 6 | Staging of brain pa- thology related to sporadic Parkinson's disease显示文摘 | Braak H Del Tredici K RUb U | 2002 | Neurobi- ol Aging2002，24，2： | 1 |
| 7 | Neuron-specific enolase and embryology of the trabecular meshwork of the rat eye:an immunohistochemical study显示文摘 | NUCCI P TREDICI G MANITTO M P | 1992 | Int J Biol Markers1992，7，： | 1 |
| 8 | Long-lasting neuropsychological changes after a single high altitude climb显示文摘 | Cavaletti G Tredici G | 1993 | Acta Neurol Scand1993，87，2： | 1 |
| 9 | Staging of brain pathology re- lated to sporadic Parkinson's clisease显示文摘 | Braak H Del Tredici K RiJb U | 2003 | Neurobiol Aging2003，24，2： | 1 |
| 10 | Ginkgo chichi in nature,legend and cultivation显示文摘 | Del Tredici P | | 0，，04： | 1 |
| 11 | Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease 显示文摘 | Braak H Del Tredici K Bratzke H | 2002 | J Neurol2002，249，3： | 1 |
| 12 | Staging of the intra- cerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)显示文摘 | Braak H Del Tredici K Bratzke H | 2002 | J Neu- rol2002，249，3： | 1 |
| 13 | APOE in{lu- ences vasospasm and cognition of noncomatose patients with subarachnoid hemorrhage显示文摘 | Lantema LA Rigoldi M Tredici G | 2005 | Neurology2005，64，7： | 1 |
| 14 | A timeline for Parkinson's disease 显示文摘 | Hawkes CH Del Tredici K Braak H | 2010 | Parkinsonism Relat Disord2010，16，2： | 1 |
| 15 | Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease显示文摘 | Braak H Sastre M Del Tredici K | 2012 | {H}Acta Neuropathologica2012，，3： | 1 |
| 16 | Identification of the first synthetic steroidogenic factor 1 inverse agonists: pharmacological modulation of steroidogenic enzymes 显示文摘 | Del Tredici A L Andersen C B Currier E A | 2008 | Mol Pharmacol2008，73，： | 1 |
| 17 | Effect of recombinant human nerve growth factor on clsplatin neurotoxicity in rats显示文摘 | TREDICI G BRAGA M NICOLINI G | 1999 | Exp Neurol1999，159，2： | 1 |
| 18 | Staging of brain pathologyrelated to sporadic parkinson's disease显示文摘 | Braak H Tredici KD Rub U | 2003 | Neurobiol Aging2003，24，： | 1 |
| 19 | Neurotoxicity of Platinum Compounds: Comparison of the Effects of Cisplatin and Oxaliplatin on the Human Neuroblastoma Cell Line SH-SY5Y显示文摘 | Elisabetta Donzelli Maria Carfì Mariarosaria Miloso Alberto Strada Stefania Galbiati Martine Bayssas Genevieve Griffon-Etienne Guido Cavaletti Maria Grazia Petruccioli Giovanni Tredici | 2004 | Journal of Neuro - Oncology (-)2004，，1： | 1 |
| 20 | Effect of recombinant human nerve growth factor on cisplatin neurotoxicity in rats显示文摘 | Tredici G Braga M Nicolini G | 1999 | Exp Neurol1999，159，2： | 1 |
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