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| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 3 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 4 | Detained microbial Survey help improve reservoir eharacterization显示文摘 | Tucker J Hitzman D C | 1994 | Oil & Gas Journal1994，92，23： | 1 |
| 5 | The Effect of Solvent Density Inhomogeneities on Solute Dynamics in Supercritieal Fluids: a Theoretical Perspective 显示文摘 | Tucker S C Maddox M W | 1998 | J Phys Chem B1998，102，： | 1 |
| 6 | African cover classification using satellite data 显示文摘 | Tucker C J Townshend J R & Goff T | 1985 | Science1985，297，： | 1 |
| 7 | Satellite remote sensing of primary production显示文摘 | Tucker C J Sellers P J | 1986 | International Journal of Remote Sensing1986，7，： | 1 |
| 8 | A global l by 1 degree NDVI data set for climatic studies part2:The generation of global fields of terrestrial biophysical parameters from the NDVI显示文摘 | Sellers P J Tucker C J Collatz G J | 1994 | International Journal of Remote Sensing1994，15，17： | 1 |
| 9 | Preynane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro 显示文摘 | Haughton EL Tucker SJ Marek C J | 2006 | Gastroenterology2006，131，1： | 1 |
| 10 | Communication of behavorial state in multi-agent retrieval tasks显示文摘 | Ronald C Arkin Tucker Balch Elizabeth Nitz | 2003 | Robotics and Automation2003，，3： | 1 |
| 11 | Antioxidant and modified atmosphere packaging prevention of discoloration in pork bones during retail display显示文摘 | NICOLALDE C STETZER A J TUCKER E M | 2006 | Meat Science2006，72，4： | 1 |
| 12 | A funda- mental study of chromium deposition on solid oxide fuel cell cathode materials显示文摘 | Tucker M C Kurokawa H Jacobson C P | 2006 | Journal of Power Sources2006，160，1： | 1 |
| 13 | Physiologically-based pharrnacoki- netics in drug development and regulatory science 显示文摘 | Rowland M Peck C Tucker G | 2011 | Annu Rev Pharmacol Toxicol2011，51，： | 1 |
| 14 | Electrochemical and long-term corrosion studies of several alloys in bare condition and plasma sprayed with Cr203 显示文摘 | ASHARY A A TUCKER R C | 1989 | Surf Coat Technol1989，4344，： | 1 |
| 15 | Developmental abnormalities and reduced fruit softening in tomato plants expressing an antisense Rabll GTPase gene显示文摘 | Lu C Zainal Z Tucker G A | 2001 | The Plant Cell Online2001，13，8： | 1 |
| 16 | The effect of solvent density inhomogeneities on solute dynamics in supercritical fluids: a theoretical perspective 显示文摘 | TUCKER S C MADDOX M W | 1998 | Journal Physical Chemistry B1998，102，14： | 1 |
| 17 | A survey into the prevalence of poultry helminths in northwest Arkansas commercial broiler chickens 显示文摘 | Wilson K Yazwinski T Tucker C | 1994 | Avian diseases1994，，： | 1 |
| 18 | The BMP signaling gradiem patterns dorsoventral tissues in a temporally progressive manner ahmg the anteroposlerior axis显示文摘 | Tucker J A Mintzer K A l:lullins M C | 2008 | Dev Cell2008，14，1： | 1 |
| 19 | An Extended AVHRR 8-kin NDVI Data Set Compatible with MODIS and SPOT Vegetation NDVI Data显示文摘 | Tucker C J Pinzon J E Brown M E | 2005 | International Journal of Remote Sensing2005，26，： | 1 |
| 20 | Immunity to Fusarium wilt in the to mato显示文摘 | Bohn G W Tucker C M | 1939 | Science1939，89，： | 1 |
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