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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 3 | Estimation of groundwater evaporation and salt flux from Owens Lake, California, USA显示文摘 | Tyler S W Kranz S Parlange M B | 1997 | Journal of hydrology1997，200，： | 1 |
| 4 | Fractal scaling of soil particle size distribution: analysis and limitations显示文摘 | TYLER S W WHEATCRAFT S W | 1992 | Soil Sci Soc Am J1992，56，： | 1 |
| 5 | Fractal processes in soil water retention显示文摘 | Tyler S W Wheatcraft S W | 1990 | Water Resources research1990，26，5： | 1 |
| 6 | Fractal processes in soil waterRetention显示文摘 | TYLER S W WHEATE S W | 1992 | WaterResourceResearch1992，28，： | 1 |
| 7 | Fractal scaling of soil particle-size distribution analysis and limitations显示文摘 | Tyler S W Wheatcraft S W | 1992 | Soil Science Society America Journal1992，，56： | 1 |
| 8 | Application of fractal mathematics to soil water retention estimation显示文摘 | Tyler S W Wheatcraft S W | 1959 | Soil Sci Soc Am J1959，，53： | 1 |
| 9 | Fractal scaling of soil particle - size distributions: analysis and limitations显示文摘 | Tyler S W Wheatcraft S W | 1992 | Soil Science Society of America Journal1992，56，： | 1 |
| 10 | Fractal processes in soil water relation 显示文摘 | Tyler S W Wheatcraft S W | 1990 | Water Resour Res1990，26，5： | 1 |
| 11 | Fractal scaling of soil particle size distribution: analysis and limitations显示文摘 | TYLER S W WHEATCRAFT S W | 1992 | Soil Sci Soc Am1992，56，： | 1 |
| 12 | DNA barcoding Australia's fish species显示文摘 | Robert D W Tyler S Z Bronwyn H I | 2005 | Philosophical Transactions of the Royal Socity B2005，360，1462： | 1 |
| 13 | Application of fractal mathematics to soil water retention estimation 显示文摘 | Tyler S W Wheatcraft S W | 1989 | Soil Science Society of America Journal1989，53，4： | 1 |
| 14 | Fractal scaling of soil particle sizedistributions: analysis and limitations 显示文摘 | Tyler S W Wheatcraft S W | 1992 | Soil Sci Soc Am J1992，56，2： | 1 |
| 15 | Fractal scaling of soil particle-size distributions:Analysis and limitations显示文摘 | Tyler S W Wheatcraft S W | 1992 | Soil Science of America Journal1992，56，： | 1 |
| 16 | Deep arid system hydrodynamics 2:Application to paleohydrologic reconstruction using vadose zone profiles from the northern Mojave Desert显示文摘 | Walvoord M A Phillips F M Tyler S W | 2002 | Water Resources Research2002，38，12： | 1 |
| 17 | An explanation to scale-dependent dispersivity in heterogeneous aquifers using concepts of fractal geometry 显示文摘 | WhEATCRAFT S W TYLER S W | 1988 | Water Resour Res1988，24，： | 1 |
| 18 | Fractal scaling of soil particle size distributions:Analysis and limitations显示文摘 | Tyler S W Wheatcraft S W | 1992 | Soil Science Societyof America Journal1992，56，： | 1 |
| 19 | Vadose-zone Tech- niques for Estimating Groundwater Recharge in Arid and Semiarid Regions显示文摘 | Alison G B Gee G B Tyler S W | 1994 | Soil Science Society of A- merica1994，58，1： | 1 |
| 20 | Temperature-profile methods for estimating percolation rates in arid environ- ments显示文摘 | Constantz J Tyler S W Kwieklis E | 2003 | Vadose Zone Journal2003，2，1： | 1 |
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