|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of simulated thermalcycles on the microstructure of the heat-affected zone in HSLA-80and HSLA-100 steel plates 显示文摘 | Shome M Gupta 0 P Mohan ty 0 N | 2004 | Metallurgical and MaterialsTransactions A2004，35，3： | 1 |
| 2 | Long-term changes of cladoceran community in a shallow hypertrophic reservoir in Hungary显示文摘 | János Korponai Gábor Paulovits Kálmán Mátyás István Tátrai | 2003 | Hydrobiologia (-)2003，，1： | 1 |
| 3 | 显示文摘 | Matumoto M Hsieh TY Zhu N | 1997 | J Virol1997，71，2： | 1 |
| 4 | Choroid plexus ependymal cells enhance neurite outgrowth f rom dorsal root ganglion neurons in vitro显示文摘 | Chakrabort ty S Kitada M Mat sumoto N | 2000 | J Neurocy2tol2000，29，： | 1 |
| 5 | Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT- 1) in macrophages and in various tissues 显示文摘 | Sakashita N Miyazaki A Takeya M Horiuchi S Chang CC Chang TY el al | 2000 | Am J Pathol2000，156，1： | 1 |
| 6 | Immunologic self-tolerance maintained by CD4+CD25+ naturally anergic and suppressive T cells: induction of autoimmune diseases by breaking their anergic/suppressive state显示文摘 | Takahashi TY Kuniyasu M Toda N | 1998 | Int Immunol1998，10，： | 1 |
| 7 | Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor显示文摘 | Matsumoto M Heieh TY Zhu N | 1997 | J Virol1997，71，11： | 1 |
| 8 | Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus) 显示文摘 | Stajich JE Wilke SK Ahren D Au CH Birren BW Borodovsky M Burns C Canback B Casselton LA Cheng CK Deng J Dietrich FS Fargo DC Farman ML Gathman AC Goldberg J Guigo R Hoegger PJ Hooker JB Huggins A James TY Kamada T Kilaru S Kodira C Kues U Kupfer D Kwan HS Lomsadze A Li W Lilly WW Ma LJ Mackey AJ Manning G Martin F Muraguchi H Natvig DO Palmerini H Ramesh MA Rehmeyer CJ Roe BA Shenoy N Stanke M Ter-Hovhannisyan V Tunlid A Velagapudi R Vision TJ Zeng Q Zolan ME Pukkila PJ | 2010 | PNAS2010，107，11： | 1 |
| 9 | Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus) 显示文摘 | Stajich JE1 Wilke SK Ahrén D Au CH Birren BW Borodovsky M Burns C Canb?ck B Casselton LA Cheng CK Deng J Dietrich FS Fargo DC Farman ML Gathman AC Goldberg J Guigó R Hoegger PJ Hooker JB Huggins A James TY Kamada T Kilaru S Kodira C Kües U Kupfer D Kwan HS Lomsadze A Li W Lilly WW Ma LJ Mackey AJ Manning G Martin F Muraguchi H Natvig DO Palmerini H Ramesh MA Rehmeyer CJ Roe BA Shenoy N Stanke M Ter-Hovhannisyan V Tunlid A Velagapudi R Vision TJ Zeng Q Zolan ME Pukkila PJ 2010 | 2010 | Proc Natl Acad Sci USA2010，107，11： | 1 |
| 10 | Hepatitis C virus core protein interacts with the cytoplasmictail of lymphotoxin-beta-receptor 显示文摘 | Matsumoto M Heieh TY Zhu N | 1997 | J Virol1997，71，11： | 1 |
| 11 | Genetic Variability of Thermal Nymphae a Populations Based on ISSR Markers: Imolications on Relationships,Hybridization, and Conservation显示文摘 | P~ter Poczai Kinga Kl~ra M~ty~s Istv~n Szab6 | 2011 | Plant MolBiol Rep2011，29，： | 1 |
| 12 | Multi-exponential model to describe pressure-dependent P-and S-wave velocities and its use to estimate the crack aspect ratio显示文摘We present new quantitative model describing the pressure dependence of acoustic P-and S-wave velocities.Assuming that a variety of individual mechanisms or defects(such as cracks,pore collapse and grain crushing)can contribute to the pressure-dependent change of the wave velocity,we order a characteristic pressure to all of them and allow a series of exponential terms in the description of the(Pand S-waves)velocity-pressure function.We estimate the parameters of the multi-exponential rock physical model in inversion procedures using laboratory measured P-and S-wave velocity data.As is known,the conventional damped least squares method gives acceptable results only when one or two individual mechanisms are assumed.Increasing the number of exponential terms leads to highly nonlinear ill-posed inverse problem.Due to this reason,we develop the spectral inversion method(SIM)in which the velocity amplitudes(the spectral lines in the characteristic pressure spectrum)are only considered as unknowns.The characteristic pressures(belonging to the velocity amplitudes)are excluded from the set of inversion unknowns,instead,they are defined in a set of fixed positions equidistantly distributed in the actual interval of the independent variable(pressure).Through this novel linear inversion method,we estimate the parameters of the multi-exponential rock physical model using laboratory measured P-and S-wave velocity data.The characteristic pressures are related to the closing pressures of cracks which are described by well-known rock mechanical relationships depending on the aspect ratio of elliptical cracks.This gives the possibility to estimate the aspect ratios in terms of the characteristic pressures. | Mihály Dobróka Norbert Péter Szabó Tünde Edit Dobróka Mátyás Krisztián Baracza | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，2： | 1 |
| 13 | The role of the Kis-Balaton water protection system in the control of water quality of LakeBalaton显示文摘 | István Tátrai Kálmán Mátyás János Korponai | 2000 | Ecological Engineering2000，16，1： | 1 |
| 14 | Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor显示文摘 | Matsumoto M Hsieh TY Zhu N | 1997 | J Virol1997，71，2： | 1 |
| 15 | Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors显示文摘Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support methods.Digital drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted agents.DDA has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical trial.The aim of this study was to evaluate the utility of DDA in pediatric oncology.Methods Between 2017 and 2020,103 high-risk pediatric cancer patients(<21 years)were involved in our precision oncology program,and samples from 100 patients were eligible for further analysis.Tissue or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision support.Finally,a molecular tumor board(MTB)evaluated the results to provide therapy recommendations.Results Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing results.DDA identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug resistance.Actionability reached 88%(29/33)by 2020 due to the continuous updates of the evidence database.MTB approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed therapies.Filtering of WES results for targeted panels missed important mutations affecting therapy selection.Conclusions DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine care of high-risk pediatric cancers.Knowledgebase updates enable automatic interpretation of a continuously expanding gene set,a“virtual”panel,filtered out from genome-wide analysis to always maximize the performance of precision treatment planning. | Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István Peták | 2023 | World Journal of Pediatrics2023，19，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员