|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats显示文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC)from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS.Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration.Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-Larginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed.RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity.Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats.Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachykinergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls.CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. | Luciano Onori Annalisa Aggio Simona D'Alo' Paola Muzi Maria Grazia Cifone Gabriella Mellillo Rachele Ciccocioppo Gennaro Taddei Giuseppe Frieri Giovanni Latella | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 2 | Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions显示文摘 | Amedeo Amedei Elena Niccolai Marisa Benagiano Chiara Della Bella Fabio Cianchi Paolo Bechi Antonio Taddei Lapo Bencini Marco Farsi Paola Cappello Domenico Prisco Francesco Novelli Mario Milco D’Elios | 2013 | Cancer Immunology, Immunotherapy2013，，7： | 2 |
| 3 | Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride- channel gating显示文摘 | Pedemonte N Sonawane N D Taddei A | 2005 | Mol Pharmacol2005，67，5： | 1 |
| 4 | Global exponential stability of the periodic solution of the delayed neural networks with discontinuous activations显示文摘 | Papini D Taddei V | | 0，，1： | 1 |
| 5 | Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants 显示文摘 | Veurink G Liu D Taddei K | 2003 | Free Radic Biol Med2003，34，8： | 1 |
| 6 | Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants显示文摘 | Veuaink G Liu D Taddei K | 2003 | Free Radic Bio Med2003，34，8： | 1 |
| 7 | The effect of histone deacetylase inhibitors on heterochromatin:implicationsfor anticancer therapy显示文摘 | Taddei A Roche D Bickmore W A | 2005 | EMBO Rep2005，6，6： | 1 |
| 8 | Reduction of inclusion body pathology in ApoE - deficient mice fed a combination of antioxidants 显示文摘 | Veurink G Liu D Taddei K | 2003 | Free Radic Biol Med2003，34，8： | 1 |
| 9 | Parmacological activity of essen- tial oils on Oddig sphincter 显示文摘 | Giachetti D Taddei E Taddei I | 1988 | Planta Med1988，54，5： | 1 |
| 10 | Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases显示文摘 | Taddei A Maison C Roche D | 2001 | Nat Cell Biol2001，3，： | 1 |
| 11 | The effect of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy? 显示文摘 | Taddei A Roche D Bickmore WA | 2005 | EMBO Rep2005，6，6： | 1 |
| 12 | Regiospecific conversion of oxiranes into primary alcohols via reaction with organotin derivatives显示文摘 | Ricci A Taddei M Tassi D | 1983 | Synthesis1983，，8： | 1 |
| 13 | Virtual palpation of skeletal landmarks with multimodal display interfaces显示文摘 | Taddei F Ansaloni M Testi D | 2007 | Med Inform Internet Med2007，32，3： | 1 |
| 14 | Kinetics of interleukin-6 and chemokine ligands 2 and 3 expression of periodontal tissues during orthodontic tooth movement 显示文摘 | D F Madureira A Taddei Sde M H Abreu | 2012 | The American Journal of Orthodontics and Dentofacial Orthopedics2012，142，4： | 1 |
| 15 | Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients显示文摘 | Versari D Cipriano A | 2006 | J Am Coll Cardiol2006，48，3： | 1 |
| 16 | Giant pelvic retropefitoneal liposarcoma显示文摘 | Susini T Taddei G Massi D | 2000 | Obstet Gynecol2000，95，62： | 1 |
| 17 | Can hysteroscopic evaluation of endometrial carcinoma influence therapeutic treatmemt显示文摘 | Taddei GC Moncini D Scarselli G | 1994 | Ann N Y Acad Sci1994，734，： | 1 |
| 18 | Global exponential stability of the periodic solution of a delayed neural network with discontinuous activations显示文摘 | Papini D Taddei V | 2005 | Phys Lett A2005，343，13： | 1 |
| 19 | Endothelial dysfunction as a target for prevention of cardiovascular disease显示文摘 | Versari D Daghini E Virdis A Ghiadoni L Taddei S | 2009 | Diabetes Care2009，2，： | 1 |
| 20 | Reduction of inclusion body pathology in ApaE-defieient mice fed a combination of antioxidants显示文摘 | Liu D Taddei K | 2003 | Free Radie Biol Med2003，34，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员