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| 1 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 2 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 3 | Development,validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry(SID-LC/ESI/SRM/MS)method for quantification of keto-androgens in human serum显示文摘 | Tamae D Byrns M Marck B | 2013 | J Steroid Biochem Mol Biol2013，138，： | 1 |
| 4 | Development of resistence against amproloum,nicbarzin,maduramysin,lasalocid and maxiban显示文摘 | Tamas T Schkeim K D Wilks G | 1991 | J Parasitol1991，，： | 1 |
| 5 | Examination of sensorimotor performance following middle cerebral artery occlusion in rats显示文摘 | Reglodi D Tamas A Lengvari I | 2003 | Brain Res Bul2003，59，6： | 1 |
| 6 | Response of cyclin B1 to ionizing radiation: regulation by NF-kappaB and mitochondrial antioxidant enzyme MnSOD 显示文摘 | Ozeki M Tamae D Hou DX | 2004 | Anticancer Res2004，24，5： | 1 |
| 7 | Trainable blotch detection on high resolution archive films minimizing the human interaction显示文摘 | Attila L Tamas S Laszlo D | 2010 | Machine Vision and Applications2010，21，5： | 1 |
| 8 | Role of PACAP in female fertility and reproduction at gonadal level-recent advances显示文摘 | Reglodi D Tamas A Koppan Mi | 2012 | Front Endocrinol(Lausanne)2012，3，： | 1 |
| 9 | Relaxation behavior of hydrophobically modified polyeleetrolyte solution under various deformations显示文摘 | Tama K C Nga W K Jenkins R D | 2005 | Polymer2005，46，： | 1 |
| 10 | The role of peroxiredoxin Ⅱ in radiation-resistant MCF-7 breast cancer cells 显示文摘 | Wang T Tamae D LeBon T | 2005 | Cancer Res2005，65，10： | 1 |
| 11 | Model of cerebral palsy in the perinatal rabbit显示文摘 | Sidhartha T Alexander D Tamas J | 2005 | Child Neurol2005，20，12： | 1 |
| 12 | Highly efficient phosphodiester hydrolysis promoted by a dinuclear copper ( Ⅱ ) complex显示文摘 | Yvonne D Ibolya T | 2001 | Inorg Chem2001，40，： | 1 |
| 13 | Examination of sen- sorimotor performance following middle cerebral artery occlu- sion in rats 显示文摘 | REGLODI D TAMAS A LENGVARI I | 2003 | Brain Res Bull2003，59，6： | 1 |
| 14 | Olter membrane proteins ofPasteurella multodida 显示文摘 | TAMAS H KE1TH A H JOHN D B | 2010 | Vet Microbiol2010，144，： | 1 |
| 15 | Model of cer-ebral palsy in the perinatal rabbit显示文摘 | Sidhartha T Alexander D Tamas J | 2005 | J Child Neurol2005，20，12： | 1 |
| 16 | Examination of sensorimotor performance following middle cerebral artery occlusion in rats 显示文摘 | Reglodi D Tamas A Lengvari 1 | 2003 | Brain Res Bull2003，59，6： | 1 |
| 17 | Electrical conductivity of cement pastes 显示文摘 | Tamas F D | 1982 | Cem Concr Re-s1982，12，1： | 1 |
| 18 | In vitro pro- duction of porcine embryos: current status, future per- spectives and alternative applications 显示文摘 | Thanh Q D Tamas S Seiki H | 2011 | Animal Science Journal2011，82，： | 1 |
| 19 | Low-frequeney electrical conductivity of cement, clinker and clinker mineral pastes 显示文摘 | Tamas F D Farkas E Voros M | 1987 | Cem Concr Res1987，17，2： | 1 |
| 20 | Bronchoscopic lung vol-ume reduction for end-stage emphysema:report on the first 98 patients显示文摘 | Wan I Y Tama T P Geddes D M | | 0，，03： | 1 |
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