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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 3 | Inhibition of focal adhesion kinase by antisense oligonucleotides enhances the sensitivity of breast cancer cells to camptothecins显示文摘 | Satoh TH Surmacz TA Nyormoi O | 2003 | Biocell2003，27，1： | 1 |
| 4 | A modified beta-amyloid hypothesis:intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade显示文摘 | Wirths O Multhaup G Bayer TA | 2004 | J Neurochem2004，91，3： | 1 |
| 5 | Chronic wound pathogenesis and current treatment strategies:a unifying hypothesis显示文摘 | Mustoe TA O'Shaughnessy K Kloeters O | | 0，，7： | 1 |
| 6 | Genistein induces radioprotection by hematopoietic stem cell quiescence 显示文摘 | Davis TA Mungunsukh O Zins S | 2005 | Int J Radiat Biol2005，84，9： | 1 |
| 7 | Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells显示文摘 | Alper O Bergmann -Leitner ES Bennett TA | 2001 | J Natl Cancer Inst2001，93，18： | 1 |
| 8 | Epidermal growth factor reeptor signaling and the invasive phenotype of ovarian carcinoma cells 显示文摘 | Alper O Bergmann - Leitner ES Bennett TA | 2001 | J Natl Cancer Inst2001，93，18： | 1 |
| 9 | TheP l a n n i n g Re s p o n s e t o Ur b a n S e r v i c e S e c t o rGrowth:an International Compar ison显示文摘 | Daniels PW O Connor K Hutton TA | 1991 | Growthand Change1991，22，4： | 1 |
| 10 | Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting:a randomized,double-blind,placebo-controlled multicenter trial显示文摘 | O'Connor TA Pearman MH | 1999 | J Clin Anesth1999，11，6： | 1 |
| 11 | Biomechanical evaluation of methods of posterior stabilization of the spine and posterior lumbar interbody arthrodesis for lumbosacral isthmus spandylisthesis显示文摘 | Shirado O Zdeblick TA McAfee PC | 1991 | J Bone Joint Surg1991，73，1： | 1 |
| 12 | Isoform-specificO-glycosylation of osteopontin and bone sialoprotein by polypep-tide N-aceylgalactosaminyltransferase-1显示文摘 | Miwa HE Gerken TA Jamison O | 2010 | J Biol Chem2010，285，2： | 1 |
| 13 | A multicenter evaluation of total intravenous anesthesia with remifentanil and propofol for elective inpatient surgery显示文摘 | Hogue CW Bowdle TA O'Leary C | 1996 | Anesth Analg1996，83，： | 1 |
| 14 | Estimation of total attenuation and scatterer size from backscattered ul- trasound waveforms 显示文摘 | Bigelow TA Oelze ML O' Brien WD | 2005 | J Acoust Soc Am2005，117，3： | 1 |
| 15 | The neurobiology and pharmacotherapy of Alzheimer's disease 显示文摘 | Felician O Sandson TA | 1999 | J Neuropsyehiatry Clin Neurosci1999，11，： | 1 |
| 16 | Progesterone receptor gene variants and risk of endometrial cancer 显示文摘 | O'Mara TA Fahey P Ferguson K etal | 2011 | Carcinogenesis2011，32，3： | 1 |
| 17 | Cervical myelopathy secondary to multiple spondylotic protrusion:a clinicopathologic study显示文摘 | Ono K O ta HK Yamamoto T | 1977 | Spine1977，22，1： | 1 |
| 18 | Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults显示文摘 | O'Leary DH Polak JF Kronmal RA Manolio TA Burke GL Wolfson SK and The Cardiovascular Health Study Collaborative Research Group | 1999 | N Engl J Med1999，340，246： | 1 |
| 19 | The role of fusion and instrumentation in the treatment of degenerative spondylolisthesis with spinal stenosis显示文摘 | BRIDWELL KH SEDGEWICK TA O'BRIEN MF | 1993 | J Spinal Disord1993，6，6： | 1 |
| 20 | Glycogen syn-thase kinase-3beta inhibition preserves hematopoieticstem cell activity and inhibits leukemic cell growth 显示文摘 | Holmes T O' Brien TA Knight R | 2008 | Stem Cells2008，26，5： | 1 |
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