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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Insights into gastric neuroendocrine tumors burden显示文摘Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors. | Taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de Assumpcao | 2017 | Chinese Journal of Cancer Research2017，29，2： | 7 |
| 3 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 4 | Heart rate recovery predicts mortality and cardiovascular events in patients with type 2 diabetes显示文摘 | Chacko KM Bauer TA Dale RA | 2008 | Med Sci Sports Exerc2008，40，2： | 1 |
| 5 | Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death显示文摘 | Matthews-Roberson TA Quintanilla RA Ding HJ | 2008 | Brain Res2008，1234，： | 1 |
| 6 | A structural model of health behavior:a pragmatic approach to explain and influence health behaviors at the population level 显示文摘 | Cohen DA Scribner RA Farley TA | 2000 | Preventive Medicine2000，30，： | 1 |
| 7 | Cancer surveillance in inflammatory bowel disease: new molecular approaches 显示文摘 | Risques RA Rabinovitch PS Brentnall TA | 2006 | Curt Opin Gastroenterol2006，22，4： | 1 |
| 8 | Reported pneumonia in patients with COPD显示文摘 | Calverley PM Stockley RA Seemungal TA | 2011 | CHEST2011，139，3： | 1 |
| 9 | Discovery of distinct protein profiles specific for lung tumors and pre-malignant lung lesions by SELD Imass spectrometry显示文摘 | Zhukov TA Johanson RA Cantor AB | 2003 | Lung Cancer2003，40，3： | 1 |
| 10 | Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease显示文摘 | Hauser RA Zesiewicz TA Martinez C | 1996 | Can J Neurol Sci1996，23，2： | 1 |
| 11 | GUS fusions: β-Glucronidase as a sensitive and versatile gene fusion marker in higher plants显示文摘 | Jefferson RA Kavanagh TA Bevan MW | 1987 | EMBO J1987，6，： | 1 |
| 12 | Pearls and pitfalls in the emergency department evaluation of abdominal pain显示文摘 | Nowicki TA Courtney DS | 2003 | Emerg Med Clin North Am2003，21，1： | 1 |
| 13 | Association of diabetes with mammographic breast density and breast caneer in the Minnesota breast cancer family study显示文摘 | Sellers TA Jensen LE Vierkant RA | 2007 | Cancer Causes Contr2007，18，5： | 1 |
| 14 | Silent brain infarction on magnetic resonance imaging and neurological abnormalities in community-dwelling older adults, the cardio-vascular health study 显示文摘 | Price TR Manolio TA Kronmal RA | 1997 | Stroke1997，28，10： | 1 |
| 15 | Acitretin for erythrokeratodermia variabilis in a 9-year-old girl显示文摘 | Graham-Brown RA Chave TA | 2002 | Pediatr Dermatol2002，19，6： | 1 |
| 16 | Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults显示文摘 | O'Leary DH Polak JF Kronmal RA Manolio TA Burke GL Wolfson SK and The Cardiovascular Health Study Collaborative Research Group | 1999 | N Engl J Med1999，340，246： | 1 |
| 17 | Cine MRI in the evaluation of the proplast-teflon TMJ interpositional implant显示文摘 | Dorsay TA Youngberg RA Orr FE | 1995 | J Comput Assit Tomogr1995，19，5： | 1 |
| 18 | Gus fusions: β-glucuronidase as a sensitive and versatile gene fusion marker in higher plants 显示文摘 | Jefferson RA Kavanagh TA Bevan MW 1987 | 1987 | EMBO J1987，6，： | 1 |
| 19 | Prevalence and correlates of de- pressive symptoms among rural older African Americans, Native Ameri- cans, and Whites with diabetes 显示文摘 | Bell RA Smith SL Arenry TA | 2005 | Diabetes Care2005，28，4： | 1 |
| 20 | Rescuer fatigue: standard versus continuous chest - compression cardiopulmonary resuscitation显示文摘 | Heidenreicb JW Berg RA Higdon TA | 2006 | Acad Emerg Med2006，13，10： | 1 |
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